Antigen processing by the proteasome

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits

1998 • 430 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly

1996 • 390 citations

Purification of an 11 S regulator of the multicatalytic protease.

1992 • 384 citations

Hybrid Proteasomes

2000 • 342 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

Characterization of Two Polyubiquitin Binding Sites in the 26 S Protease Subunit 5a

1998 • 307 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Detecting and Measuring Cotranslational Protein Degradation in Vivo

2000 • 247 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

1997 • 208 citations

Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.

1996 • 191 citations

Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome

2000 • 191 citations

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex

1998 • 188 citations

Different proteasome subtypes in a single tissue exhibit different enzymatic properties 1 1Edited by R. Huber

2000 • 188 citations

Structure of the proteasome activator REGα (PA28α)

1997 • 187 citations

Activation of the multicatalytic proteinase from rat skeletal muscle by fatty acids or sodium dodecyl sulphate

1985 • 184 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits

1997 • 181 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

Impaired Immunoproteasome Assembly and Immune Responses in PA28 ^−/− Mice

1999 • 177 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

1995 • 155 citations

An algorithm for the prediction of proteasomal cleavages

2000 • 154 citations

20 S proteasomes are assembled via distinct precursor complexes processing of LMP2 and LMP7 proproteins takes place in 13–16 S preproteasome complexes

1994 • 146 citations

A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules

1998 • 144 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

Effects on NF-κB1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

1996 • 137 citations

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber

1999 • 129 citations

Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(β5i) incorporation into 20 S proteasomes 1 1Edited by R. Huber

2000 • 126 citations

The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

1998 • 124 citations

Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

2000 • 121 citations

MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells

2000 • 117 citations

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

1989 • 115 citations

HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation

1997 • 111 citations

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28

2000 • 106 citations

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses

2000 • 106 citations

Functional analysis of the proteasome regulatory particle.

1999 • 106 citations

Generation and TAP-Mediated Transport of Peptides for Major Histocompatibility Complex Class I Molecules

1998 • 102 citations

Mechanisms of Viral Interference with MHC Class I Antigen Processing and Presentation

1999 • 96 citations

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

2000 • 95 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells

1999 • 89 citations

Regulation of the 26S proteasome by adenovirus E1A

2000 • 88 citations

Transporter Associated with Antigen Processing**This article was accepted for publication on 1 October 1996.

1997 • 83 citations

A Kinetic Model of Vertebrate 20S Proteasome Accounting for the Generation of Major Proteolytic Fragments from Oligomeric Peptide Substrates

2000 • 79 citations

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28

2000 • 77 citations

The proteasome regulator PA28α/β can enhance antigen presentation without affecting 20S proteasome subunit composition

2000 • 68 citations

Double‐cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

1997 • 59 citations

Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein

1998 • 55 citations

Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme

1997 • 51 citations

The 19S ring-type particles of Drosophila

1987 • 46 citations

The Effect of Heat Shock on 20S/26S Proteasomes

2000 • 46 citations

Contribution of Proline Residue for Efficient Production of MHC Class I Ligands by Proteasomes

1998 • 45 citations

Significance of the rapid degradation of newly synthesized proteins in mammalian cells: A working hypothesis

1982 • 39 citations

Sequence information within proteasomal prosequences mediates efficient integration of β-subunits into the 20 s proteasome complex

1999 • 37 citations

Breakage of polynucleotide strands by disintegration of radiophosphorus atoms in DNA molecules and their repair

1967 • 28 citations

HsN3 Proteasomal Subunit as a Target for Human Immunodeficiency Virus Type 1 Nef Protein

1997 • 23 citations

Influence of single amino acid exchanges in epitope generation by 20S proteasome.

1998 • 3 citations