Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Direct Analysis and Identification of Proteins in Mixtures by LC/MS/MS and Database Searching at the Low-Femtomole Level

1997 • 516 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

X-Ray Crystal Structure of HLA-DR4 (DRA*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II

1997 • 357 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Subfemtomole MS and MS/MS Peptide Sequence Analysis Using Nano-HPLC Micro-ESI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2000 • 284 citations

On the complexity of self

1991 • 261 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Database searching using mass spectrometry data

1998 • 233 citations

A Microscale Electrospray Interface for Online, Capillary Liquid Chromatography/Tandem Mass Spectrometry of Complex Peptide Mixtures

1995 • 202 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.

1993 • 154 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1996 • 139 citations

Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401.

1994 • 127 citations

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

1994 • 127 citations

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

1997 • 111 citations

Glutamic Acid Decarboxylase – Gene to Antigen to Disease

1996 • 96 citations

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

1994 • 91 citations

Mass Spectrometry in Biology & Medicine

2000 • 90 citations

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

1997 • 89 citations

T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

1997 • 81 citations

Molecular autoimmunity

1992 • 64 citations

High Affinity Presentation of an Autoantigenic Peptide in Type I Diabetes by an HLA Class II Protein Encoded in a Haplotype Protecting From Disease

1997 • 55 citations

The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.

1996 • 26 citations

Glutamic acid decarboxylase and other autoantigens in IDDM

1995 • 26 citations

T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4

1995 • 20 citations

In Vitro Stimulation with Glutamic Acid Decarboxylase (GAD65) Leads to an Oligoclonal Response of Peripheral T‐Cells in an IDDM Patient

1995 • 9 citations