Contribution of mass spectrometry to contemporary immunology

Electrospray Ionization for Mass Spectrometry of Large Biomolecules

1989 • 7,324 citations

Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

1988 • 5,560 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Analytical Properties of the Nanoelectrospray Ion Source

1996 • 1,816 citations

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1996 • 1,687 citations

Error-Tolerant Identification of Peptides in Sequence Databases by Peptide Sequence Tags

1994 • 1,475 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Protein sequencing by tandem mass spectrometry.

1986 • 1,165 citations

Fast atom bombardment of solids (F.A.B.): a new ion source for mass spectrometry

1981 • 1,100 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Contributions of mass spectrometry to peptide and protein structure

1988 • 992 citations

Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers

1991 • 979 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Influence of Peptide Composition, Gas-Phase Basicity, and Chemical Modification on Fragmentation Efficiency: Evidence for the Mobile Proton Model

1996 • 863 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

The interpretation of collision‐induced dissociation tandem mass spectra of peptides

1995 • 651 citations

On-line mass spectrometric detection for capillary zone electrophoresis

1987 • 619 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Collision-induced fragmentation of (M + H)+ ions of peptides. Side chain specific sequence ions

1988 • 473 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

Novel fragmentation process of peptides by collision-induced decomposition in a tandem mass spectrometer: differentiation of leucine and isoleucine

1987 • 437 citations

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

1998 • 434 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Capillary zone electrophoresis-mass spectrometry using an electrospray ionization interface

1988 • 386 citations

Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry

1996 • 384 citations

Structure of Peptides Associated with Class I and Class II MHC Molecules

1994 • 381 citations

Human H-Y: a Male-Specific Histocompatibility Antigen Derived from the SMCY Protein

1995 • 358 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy

1997 • 346 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

MHC Ligands and Peptide Motifs

1997 • 336 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Invited anniversary review: HLA associated diseases

1997 • 278 citations

Mass spectrometric sequencing of linear peptides by product‐ion analysis in a reflectron time‐of‐flight mass spectrometer using matrix‐assisted laser desorption ionization

1993 • 269 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Instrumental Requirements for Nanoscale Liquid Chromatography

1996 • 264 citations

On the complexity of self

1991 • 261 citations

Fast atom bombardment: A new mass spectrometric method for peptide sequence analysis

1981 • 260 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Electrospray ionization combined with ion trap mass spectrometry

1990 • 246 citations

Fragmentation reactions of multiply-protonated peptides and implications for sequencing by tandem mass spectrometry with low-energy collision-induced dissociation

1993 • 246 citations

Charge‐remote fragmentations: Analytical applications and fundamental studies

1990 • 236 citations

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.

1994 • 221 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes.

1995 • 208 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Identification of a mouse male-specific transplantation antigen, H-Y

1995 • 192 citations

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

1992 • 174 citations

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry

1995 • 165 citations

Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.

1993 • 164 citations

Metastable decomposition of peptide [M + H]⁺ ions via rearrangement involving loss of the C-terminal amino acid residue

1990 • 161 citations

Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia

1988 • 157 citations

The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68

1997 • 148 citations

Influence of cysteine to cysteic acid oxidation on the collision-activated decomposition of protonated peptides: Evidence for intraionic interactions

1992 • 143 citations

Method for the electrospray ionization of highly conductive aqueous solutions

1991 • 136 citations

Rapid protein identification using a microscale electrospray LC/MS system on an ion trap mass spectrometer

1998 • 134 citations

Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

1993 • 128 citations

Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.

1993 • 122 citations

The Class I Antigen-processing Pathway for the Membrane Protein Tyrosinase Involves Translation in the Endoplasmic Reticulum and Processing in the Cytosol

1998 • 120 citations

Capillary Zone Electrophoresis−Electrospray Mass Spectrometry at Submicroliter Flow Rates: Practical Considerations and Analytical Performance

1997 • 115 citations

A Listeria monocytogenes Pentapeptide Is Presented to Cytolytic T Lymphocytes by the H2-M3 MHC Class Ib Molecule

1996 • 111 citations

APPLICATION OF MASS SPECTROMETRY TO STRUCTURE PROBLEMS. I. AMINO ACID SEQUENCE IN PEPTIDES

1959 • 109 citations

Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.

1996 • 106 citations

Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes

1997 • 105 citations

Glutaredoxin from Rabbit Bone Marrow

1989 • 103 citations

Nanoscale packed-capillary liquid chromatography coupled with mass spectrometry using a coaxial continuous-flow fast atom bombardment interface

1991 • 102 citations

Capillary electrophoresis-atmospheric pressure ionization mass spectrometry for the characterization of peptides

1991 • 96 citations

Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes

1997 • 95 citations

Sequence analysis of polypeptides by collision activated dissociation on a triple quadrupole mass spectrometer

1981 • 91 citations

Utility of membrane preconcentration-capillary electrophoresis-mass spectrometry in overcoming limited sample loading for analysis of biologically derived drug metabolites, peptides, and proteins

1997 • 81 citations

Cytotoxic T-lymphocyte response to autologous human squamous cell cancer of the lung: epitope reconstitution with peptides extracted from HLA-Aw68.

1994 • 77 citations

N-methylation de peptides par la methode de hakomori. Structure du mycoside Cbl.

1968 • 77 citations

Simplified High-Sensitivity Sequencing of a Major Histocompatibility Complex Class I-Associated Immunoreactive Peptide Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

1995 • 72 citations

A Microcapillary Column Switching HPLC−Electrospray Ionization MS System for the Direct Identification of Peptides Presented by Major Histocompatibility Complex Class I Molecules

1998 • 64 citations

A novel μ-ESI source for coupling capillary electrophoresis and mass spectrometry: Sequence determination of tumor peptides at the attomole level

1998 • 61 citations

Rapid loading of large sample volumes, analyte cleanup, and modified moving boundary transient isotachophoresis conditions for membrane preconcentration-capillary electrophoresis in small diameter capillaries

1996 • 58 citations

[23] Quadrupole ion trap mass spectrometry

1996 • 54 citations

On‐line preconcentration‐capillary electrophoresis‐mass spectrometry (PC‐CE‐MS)

1994 • 50 citations

A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity.

1997 • 49 citations

Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment

1989 • 48 citations

Demonstration of virus-specific CD8+ memory T cells in measles-seropositive individuals by in vitro peptide stimulation

1995 • 48 citations

Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects.

1996 • 47 citations

Methods to study peptides associated with MHC class I molecules

1994 • 46 citations

Primary structure of macromomycin, an antitumor antibiotic protein.

1983 • 44 citations

Analysis of the structure of naturally processed peptides bound by Class I and Class II major histocompatibility complex molecules

1995 • 41 citations

Mass spectrometric analysis of peptides associated with the human class I MHC molecules HLA-A2.1 and HLA-B7 and identification of structural features that determine binding.

1993 • 32 citations

Amino acid sequence determination by g.l.c.-mass spectrometry of permethylated peptides. Optimization of the formation of chemical derivatives at the 2-10 nmol level

1983 • 31 citations

MHC Class I/peptide interactions: Binding specificity and kinetics

1993 • 31 citations

Introduction To Microscale High-Performance Liquid Chromatography

1989 • 30 citations

Novel HY peptide antigens presented by HLA-B27.

1997 • 29 citations

Application of Mass Spectrometry to Protein Chemistry. I. Method for Amino-Terminal Sequence Analysis of Proteins.

1970 • 26 citations

Calcium does not uncouple oxidative phosphorylation in tightly-coupled mitochondria from Ehrlich ascites tumour cells

1974 • 25 citations

Chemical modification of peptides by hydrazine

1981 • 23 citations

On-line derivatization of peptides for improved sequence analysis by micro-column liquid chromatography coupled with electrospray ionization-tandem mass spectrometry

1997 • 21 citations

Development of a precolumn capillary liquid chromatography switching system for coupling to mass spectrometry

1996 • 20 citations

Mass Spectrometric Analysis of Peptides Associated with the Human Class I MHC Molecules HLA-A2.1 and HLA-B7 and Identification of Structural Features that Determine Binding

1993 • 18 citations

The separation and sequencing of permethylated peptides by mass spectrometry directly coupled to gas-liquid chromatography

1976 • 17 citations

Conservation of minor histocompatibility antigens between human and non‐human primates

1996 • 13 citations

Isolation and Characterization of Naturally Processed Peptides Bound by Class II Molecules and Peptides Presented by Normal and Mutant Antigen-Presenting Cells

2015 • 11 citations

Nachweis von Fragment‐Genesen im Massenspektrometer. 3. Mitteilung. Aminosäuresequenz‐Analyse in Oligopeptiden und Oligopeptid‐Gemischen mit Hilfe der DADI‐Massenspektrometrie

1976 • 10 citations

The amino acid sequences of eleven tryptic peptides of papaya mosaic virus protein by electron ionization mass spectrometry

1982 • 6 citations

Isolation and Characterization of Naturally Processed Peptides Bound by Class II Molecules and Peptides Presented by Normal and Mutant Antigen-Presenting Cells

1993 • 5 citations