Cancer: the evolved consequence of a destabilized genome

The Hallmarks of Cancer

2000 • 27,569 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

2001 • 923 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Mutations in the APC tumour suppressor gene cause chromosomal instability

2001 • 722 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

DNA MISMATCH REPAIR AND GENETIC INSTABILITY

2000 • 601 citations

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

2001 • 553 citations

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

2001 • 525 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

Evolution of neoplastic cell lineages in Barrett oesophagus

1999 • 448 citations

The onset and extent of genomic instability in sporadic colorectal tumor progression

1999 • 388 citations

Top-down morphogenesis of colorectal tumors

2001 • 370 citations

Insights into the functions of BRCA1 and BRCA2

2000 • 335 citations

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

2001 • 323 citations

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

2001 • 320 citations

New perspectives in clinical oncology from angiogenesis research

1996 • 253 citations

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC

1995 • 252 citations

Cancer of the microsatellite mutator phenotype.

1996 • 226 citations

Clinical trials of Herceptin® (trastuzumab)

2001 • 216 citations

Genome-wide Detection of Allelic Imbalance Using Human SNPs and High-density DNA Arrays

2000 • 213 citations

Cancer: looking outside the genome

2000 • 187 citations

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

2001 • 171 citations

Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma

2000 • 124 citations

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

2001 • 121 citations

Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping

2000 • 121 citations

Spontaneous DNA Damage, Genome Instability, and Cancer—When DNA Replication Escapes Control

2001 • 116 citations

An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer.

2000 • 111 citations

CHASING THE CANCER DEMON

2000 • 109 citations

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

1999 • 100 citations

Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors.

2000 • 95 citations

Molecular evolution of multiple recurrent cancers of the bladder

2000 • 90 citations

Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer

2000 • 82 citations

Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.

2000 • 75 citations

Selected cell and selective microenvironment in neoplastic development.

2001 • 68 citations

Genomic instability in sporadic colorectal cancer quantitated by inter-simple sequence repeat PCR analysis

1997 • 63 citations

Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015

2000 • 56 citations

p53 Tumor Suppressor Gene Status and the Degree of Genomic Instability in Sporadic Colorectal Cancers

1996 • 45 citations

The Cancer Genome Anatomy Project: EST Sequencing and the Genetics of Cancer Progression

1999 • 37 citations

Different patterns of DNA alterations detected by restriction landmark genomic scanning in heterogeneous prostate carcinomas.

1997 • 19 citations

Gene therapy: recent progress in the clinical oncology arena.

2000 • 12 citations

Identification of additional complementation groups that regulate genomic instability

1997 • 6 citations