Methods for Prediction of Peptide Binding to MHC Molecules: A Comparative Study

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Parallel Distributed Processing

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SYFPEITHI: database for MHC ligands and peptide motifs

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Hidden Markov Models in Computational Biology

1994 • 1,954 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

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Hidden Markov models for sequence analysis: extension and analysis of the basic method

1996 • 448 citations

Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

1994 • 345 citations

Neural Computing: An Introduction

1990 • 326 citations

Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning.

1994 • 304 citations

Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network.

1998 • 299 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

Two complementary methods for predicting peptides binding major histocompatibility complex molecules

1997 • 261 citations

Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11

1999 • 231 citations

MHCPEP, a database of MHC-binding peptides: update 1997

1998 • 213 citations

Neural network-based prediction of candidate T-cell epitopes

1998 • 180 citations

Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes

1998 • 177 citations

Predicting peptides that bind to MHC molecules using supervised learning of hidden markov models

1998 • 176 citations

Predicting Binding Affinities of Protein Ligands from Three-Dimensional Models: Application to Peptide Binding to Class I Major Histocompatibility Proteins

1999 • 161 citations

Melan-A/MART-1_51–73represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4⁺T cells

2000 • 160 citations

The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes.

1999 • 138 citations

Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach

2000 • 134 citations

MHCPEP, a database of MHC-binding peptides: update 1996

1997 • 132 citations

Toward the Quantitative Prediction of T-Cell Epitopes: CoMFA and CoMSIA Studies of Peptides with Affinity for the Class I MHC Molecule HLA-A*0201

2001 • 123 citations

Structural principles that govern the peptide-binding motifs of class I MHC molecules

1998 • 122 citations

Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections

1999 • 97 citations

Prediction of binding to MHC class I molecules

1995 • 80 citations

An empirical method for the prediction of T-cell epitopes

1995 • 73 citations

Poor correspondence between predicted and experimental binding of peptides to class I MHC molecules

2000 • 65 citations

Cutting Edge: Identification of Novel T Cell Epitopes in Lol p5a by Computational Prediction

1999 • 54 citations

HLA-B15 Peptide Ligands Are Preferentially Anchored at Their C Termini

1999 • 54 citations

Specific and general HLA-DR binding motifs: comparison of algorithms

2000 • 51 citations

Use of Complete Eluted Peptide Sequence Data from HLA-DR and -DQ Molecules to Predict T Cell Epitopes, and the Influence of the Nonbinding Terminal Regions of Ligands in Epitope Selection

1998 • 48 citations

Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries

2001 • 47 citations

Fine tuning of peptide binding to HLA-B*3501 molecules by nonanchor residues.

1995 • 45 citations

Identification of Subdominant Cytotoxic T Lymphocyte Epitopes Encoded by Autologous HIV Type 1 Sequences, Using Dendritic Cell Stimulation and Computer-Driven Algorithm

2000 • 41 citations

Class II MHC quantitative binding motifs derived from a large molecular database with a versatile iterative stepwise discriminant analysis meta-algorithm.

1999 • 40 citations

Tumor-associated antigens identified by mRNA expression profiling induce protective anti-tumor immunity

2001 • 39 citations

Efficient discovery of immune response targets by cyclical refinement of QSAR models of peptide binding

2001 • 37 citations

Selection of peptides that bind to the HLA-A2.1 molecule by molecular modelling

1996 • 36 citations

Letters in Peptide Science

2003 • 33 citations

Statistical comparison of established T-cell epitope predictors against a large database of human and murine antigens

1996 • 24 citations

Untitled

1999 • 22 citations