Therapeutic Vaccination for Cancer

Dendritic cells and the control of immunity

1998 • 14,345 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

1993 • 888 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

The Coxsackievirus-Adenovirus Receptor Protein Can Function as a Cellular Attachment Protein for Adenovirus Serotypes from Subgroups A, C, D, E, and F

1998 • 629 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

1998 • 419 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

1997 • 383 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

LOSS OF ADENOVIRAL RECEPTOR EXPRESSION IN HUMAN BLADDER CANCER CELLS- A POTENTIAL IMPACT ON THE EFFICACY OF GENE THERAPY

1999 • 345 citations

Immunotherapy of malignancy by in vivo gene transfer into tumors.

1993 • 320 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

1990 • 300 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.

1993 • 274 citations

Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide.

1986 • 255 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

VIRAL ONCOLYSIS: INCREASED IMMUNOGENICITY OF HOST CELL ANTIGEN ASSOCIATED WITH INFLUENZA VIRUS

1967 • 234 citations

Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.

1996 • 232 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.

1991 • 225 citations

Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

1996 • 209 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.

1997 • 200 citations

Targeting gene therapy to cancer: a review.

1997 • 186 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

A reassessment of the role of B7-1 expression in tumor rejection.

1995 • 178 citations

Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study

1998 • 167 citations

In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity

1998 • 160 citations

A nonimmunogenic sarcoma transduced with the cDNA for interferon gamma elicits CD8+ T cells against the wild-type tumor: correlation with antigen presentation capability.

1992 • 159 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

Gene Transfer as Cancer Therapy

1995 • 142 citations

4-1BBL Cooperates with B7-1 and B7-2 in Converting a B Cell Lymphoma Cell Line into a Long-Lasting Antitumor Vaccine

1999 • 130 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

Cancer vaccines: the interleukin 2 dosage effect.

1995 • 127 citations

Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

1999 • 122 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

Gene Immunotherapy in Murine Acute Myeloid Leukemia: Granulocyte-Macrophage Colony-Stimulating Factor Tumor Cell Vaccines Elicit More Potent Antitumor Immunity Compared With B7 Family and Other Cytokine Vaccines

1998 • 118 citations

A Universal Granulocyte-Macrophage Colony-Stimulating Factor-Producing Bystander Cell Line for Use in the Formulation of Autologous Tumor Cell-Based Vaccines

1999 • 116 citations

New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors

1997 • 112 citations

Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene.

1988 • 110 citations

A phase I clinical trial of immunotherapy with interferon-? gene-modified autologous melanoma cells

1997 • 108 citations

Vaccination for experimental gliomas using GM-CSF-transduced glioma cells.

1997 • 108 citations

Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.

1998 • 100 citations

Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cells

1990 • 98 citations

Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

1998 • 98 citations

Influence of gene-modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation.

1997 • 85 citations

The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity.

1994 • 85 citations

Enhanced Tumor Protection by Granulocyte-Macrophage Colony-Stimulating Factor Expression at the Site of an Allogeneic Vaccine

1998 • 84 citations

Immunotheraphy of cancer using local administration of lymphoid cells transformed by IL-2 cDNA and constitutively producing IL-2

1990 • 83 citations

Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor.

1993 • 83 citations

MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4+ T Lymphocytes1

1998 • 81 citations

Ex-vivo gene therapy using cytokine-transduced tumor vaccines: molecular and clinical pharmacology.

1998 • 80 citations

Interleukin-2 Gene-Modified Allogeneic Tumor Cells for Treatment of Relapsed Neuroblastoma

1998 • 77 citations

Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.

1998 • 76 citations

A phase-I clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer

1997 • 69 citations

Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells

1997 • 67 citations

Active immunization of metastatic melanoma patients with interleukin-2-transduced allogeneic melanoma cells: evaluation of efficacy and tolerability

1997 • 66 citations

Development of Human Granulocyte-Macrophage Colony-Stimulating Factor-Transfected Tumor Cell Vaccines for the Treatment of Spontaneous Canine Cancer

1998 • 63 citations

Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines.

1996 • 63 citations

Serological response of melanoma patients to vaccines prepared from VSV lysates of autologous and allogeneic cultured melanoma cells

1985 • 61 citations

Systemic and Local Paracrine Cytokine Therapies Using Transduced Tumor Cells Are Synergistic in Treating Intracranial Tumors

1996 • 57 citations

Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld).

1987 • 57 citations

Interleukin 12 gene therapy of MHC-negative murine melanoma metastases.

1998 • 56 citations

Poxvirus-based vectors as vaccine candidates.

1990 • 56 citations

Cancer Gene Therapy Using Tumor Cells Infected with Recombinant Vaccinia Virus Expressing GM-CSF

1996 • 55 citations

Interleukin‐12‐secreting human papillomavirus type 16–transformed cells provide a potent cancer vaccine that generates E7‐directed immunity

1999 • 47 citations

Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism.

1993 • 47 citations

Genetic modification of a carcinoma with the IL-4 gene increases the influx of dendritic cells relative to other cytokines

1997 • 45 citations

Broadened Clinical Utility of Gene Gun-Mediated, Granulocyte-Macrophage Colony-Stimulating Factor cDNA-Based Tumor Cell Vaccines as Demonstrated with a Mouse Myeloma Model

1998 • 44 citations

Tumor-specific immunity can be enhanced by transfection of tumor cells with syngeneic MHC-class-II genes or allogeneic MHC-class-I genes

1991 • 44 citations

IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.

1998 • 44 citations

Considerations for the Clinical Development of Cytokine Gene-Transduced Tumor Cell Vaccines

1997 • 43 citations

Irradiated tumor cells adenovirally engineered to secrete granulocyte/macrophage-colony-stimulating factor establish antitumor immunity and eliminate pre-existing tumors in syngeneic mice

1998 • 41 citations

Extrathymic Acquisition of Tolerance by T Lymphocytes

1989 • 38 citations

Immunization with a Syngeneic Tumor Infected with Recombinant Vaccinia Virus Expressing Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Induces Tumor Regression and Long-Lasting Systemic Immunity

1997 • 37 citations

Regression of Established Mouse Leukemia by GM-CSF-Transduced Tumor Vaccine: Implications for Cytotoxic T Lymphocyte Responses and Tumor Burdens

1997 • 37 citations

Electron paramagnetic resonance evidence of the generation of superoxide (O2.− and hydroxyl (.OH) radicals by irradiation of a new photodynamic therapy photosensitizer, Victoria Blue BO

1996 • 37 citations

Vaccine effect of granulocyte–macrophage colony-stimulating factor or CD80 gene-transduced murine hematopoietic tumor cells and their cooperative enhancement of antitumor immunity

1998 • 36 citations

Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity

1999 • 35 citations

In Situ Interleukin-4 Gene Expression in Cancer Patients Treated with Genetically Modified Tumor Vaccine

1995 • 31 citations

Ex Vivo and In Vivo Adenovirus-Mediated Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defence in the B16 Melanoma Model

1998 • 30 citations

Immune stimulatory potential of B7.1 and B7.2 retrovirally transduced melanoma cells: suppression by interleukin 10

1998 • 29 citations

Poxvirus-Based Vectors as Vaccine Candidates

1995 • 25 citations

GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice

1997 • 25 citations

Colon cancer cell vaccine prepared with replication-deficient vaccinia viruses encoding B7.1 and interleukin-2 induce antitumor response in syngeneic mice

1998 • 24 citations

Sustained cytokine delivery for anticancer vaccination: liposomes as alternative for gene-transfected tumor cells.

1998 • 22 citations

In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors

1999 • 19 citations

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine Interleukin 12

1998 • 19 citations

Sensitizing T-lymphocytes for adoptive immunotherapy by vaccination with wild-type or cytokine gene-transduced melanoma

1997 • 17 citations

Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene

1997 • 14 citations

Immunotherapy against murine leukemia

1998 • 12 citations

Growth regulation and steroid hormone resistance in breast cancer

2000 • 1 citations