Adjuvant immunotherapy for solid tumors: from promise to clinical application

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993

1999 • 1,967 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients

1989 • 1,003 citations

High- and Low-Dose Interferon Alfa-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190

2000 • 923 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer.

1997 • 582 citations

Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation

2001 • 576 citations

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer

1996 • 538 citations

Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial.

1998 • 530 citations

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

1994 • 522 citations

Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma.

2000 • 438 citations

BCG lmmunotherapy of Malignant Melanoma

1974 • 430 citations

Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy

1997 • 418 citations

Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases

1997 • 309 citations

Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

1990 • 300 citations

Bacillus Calmette-Guérin therapy alters the progression of superficial bladder cancer.

1988 • 288 citations

A Randomized Trial of Adjuvant Chemotherapy and Immunotherapy in Cutaneous Melanoma

1982 • 282 citations

A combined analysis of European Organization for Research and Treatment of Cancer, and Medical Research Council randomized clinical trials for the prophylactic treatment of stage TaT1 bladder cancer. European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council Working Party on Superficial Bladder Cancer.

1996 • 273 citations

Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma

2001 • 271 citations

Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor

1995 • 269 citations

DNA vaccines: a key for inducing long-term cellular immunity

2000 • 265 citations

Interferon Adjuvant to Radical Nephrectomy in Robson Stages II and III Renal Cell Carcinoma: A Multicentric Randomized Study

2001 • 265 citations

Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer

1994 • 257 citations

Randomized, surgical adjuvant clinical trial of recombinant interferon alfa-2a in selected patients with malignant melanoma.

1995 • 253 citations

Cytokines and Immune Response in the Tumor Microenvironment

2001 • 250 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

Effects of Interleukin-12 on the Immune Response to a Multipeptide Vaccine for Resected Metastatic Melanoma

2001 • 243 citations

A prospective randomized trial of maintenance versus nonmaintenance intravesical bacillus Calmette-Guérin therapy of superficial bladder cancer.

1987 • 227 citations

Phase I trial of a MART-1 peptide vaccine with incomplete Freund's adjuvant for resected high-risk melanoma.

1999 • 223 citations

Phase I trial of a melanoma vaccine with gp100(280-288) peptide and tetanus helper peptide in adjuvant: immunologic and clinical outcomes.

2001 • 223 citations

Clinical trials of Herceptin® (trastuzumab)

2001 • 216 citations

Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21.

2000 • 201 citations

Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal Antibody

1995 • 194 citations

The Secondary Leukemias: Challenges and Research Directions

1996 • 172 citations

Adjuvant immunotherapy treatment of renal carcinoma patients with autologous tumor cells and Bacillus Calmette-Guèrin: Five-year results of a prospective randomized study

1996 • 172 citations

A phase II study on the postsurgical management of stage II malignant melanoma with a Newcastle disease virus oncolysate

1983 • 171 citations

Treatment of Metastatic Renal Cell Carcinoma With Nephrectomy, Interleukin-2 and Cytokine-Primed or CD8(+) Selected Tumor Infiltrating Lymphocytes from Primary Tumor

1997 • 162 citations

Cell-mediated immune responses to MUC1 fusion protein coupled to mannan

1996 • 138 citations

Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

1995 • 138 citations

Vaccine therapy for malignant melanoma

1996 • 133 citations

Newcastle disease virus-infected intact autologous tumor cell vaccine for adjuvant active specific immunotherapy of resected colorectal carcinoma.

1996 • 130 citations

Autologous hapten-modified melanoma vaccine as postsurgical adjuvant treatment after resection of nodal metastases.

1997 • 128 citations

Immunization of ovarian cancer patients with a synthetic Lewisy-protein conjugate vaccine: A phase 1 trial

2000 • 126 citations

Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state.

1997 • 118 citations

Clinical Trial Designs for the Early Clinical Development of Therapeutic Cancer Vaccines

2001 • 111 citations

Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cells

1990 • 98 citations

Cytoreductive surgery and adjuvant immunotherapy: a new management paradigm for metastatic melanoma

1999 • 93 citations

Antigen‐presenting cells pulsed with unfractionated tumor‐derived peptides are potent tumor vaccines

1997 • 90 citations

Patient Preferences for Adjuvant Interferon Alfa-2b Treatment

2001 • 88 citations

Cytokine-dependent regulation of growth and maturation in murine epidermal dendritic cell lines

1995 • 75 citations

Improved immunotherapy of a recombinant carcinoembryonic antigen vaccinia vaccine when given in combination with interleukin-2.

1996 • 70 citations

A natural history of melanoma: serial gene expression analysis

2000 • 69 citations

Eastern cooperative group trial of interferon gamma in metastatic melanoma: an innovative study design.

1996 • 67 citations

Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by interferon‐γ: abrogation of immune response defect to a T‐cell‐dependent antigen

1996 • 66 citations

Improved survival of patients with melanoma with an antibody response to immunization to a polyvalent melanoma vaccine

1995 • 62 citations

Vaccination of Melanoma Patients with Interleukin 4 Gene-Transduced Allogeneic Melanoma Cells

1999 • 59 citations

Clonal expansion of T lymphocytes in human melanoma metastases after treatment with a hapten-modified autologous tumor vaccine.

1997 • 57 citations

Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: a trial comparing doses of G(D2)-keyhole limpet hemocyanin.

2000 • 54 citations

Corynebacterium parvum versus BCG adjuvant immunotherapy in human malignant melanoma

1983 • 54 citations

In vitro propagated dendritic cells from prostate cancer patients as a component of prostate cancer immunotherapy

1995 • 51 citations

Increased Survival of Patients Treated With a Vaccinia Melanoma Oncolysate Vaccine

1997 • 47 citations

Melanoma vaccines: the paradox of T cell activation without clinical response

2000 • 45 citations

Monoclonal antibody-based therapy

1996 • 42 citations

Pancarcinoma T/Tn Antigen Detects Human Carcinoma Long before Biopsy Does and Its Vaccine Prevents Breast Carcinoma Recurrencea

1993 • 39 citations

Immunogenicity and Clinical Activity of a Polyvalent Melanoma Antigen Vaccine Prepared from Shed Antigensa

1993 • 36 citations

Adjuvant therapy of renal cell carcinoma with active-specific-immunotherapy (ASI) using autologous tumor vaccine.

1997 • 31 citations

Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector

2000 • 24 citations

Adjuvant immunotherapy in renal cell carcinoma--comparison of interferon alpha treatment with an untreated control.

1999 • 22 citations

Preoperative immunostimulation by Propionibacterium granulosum KP-45 in colorectal cancer.

1994 • 20 citations

Clinical experience with BCG alone versus BCG plus epirubicin

2000 • 20 citations

Monoclonal Antibodies in the Treatment of Human B-Cell Malignancies

1998 • 15 citations

Tumor idiotype vaccines

1993 • 7 citations