Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Treatment of Patients With Metastatic Melanoma With Autologous Tumor-Infiltrating Lymphocytes and Interleukin 2

1994 • 991 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

T cell defined tumor antigens

1997 • 641 citations

A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

1992 • 552 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

1995 • 416 citations

High and Low Annealing Temperatures Increase Both Specificity and Yield in Touchdown and Stepdown PCR

1996 • 409 citations

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

1993 • 375 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1996 • 272 citations

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen.

1996 • 261 citations

A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene.

1996 • 235 citations

Expression of mage genes by non‐small‐cell lung carcinomas

1994 • 230 citations

Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis.

1995 • 227 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes

1992 • 198 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Optimization of DNase I Removal of Contaminating DNA from RNA for Use in Quantitative RNA-PCR

1996 • 177 citations

Molecular characterization of the melanocyte lineage-specific antigen gp100.

1994 • 169 citations

The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma-reactive tumor-infiltrating lymphocytes.

1997 • 121 citations

Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2

1994 • 117 citations

Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt–Koyanagi–Harada disease

1996 • 107 citations

Distribution of Human Leukocyte Antigen‐ABC and ‐D/DR Antigens in the Unfixed Human Testis

1988 • 104 citations

Recognition of an Antigenic Peptide Derived from Tyrosinase-Related Protein-2 by CTL in the Context of HLA-A31 and -A33

1998 • 103 citations

Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames.

1996 • 100 citations

Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.

1996 • 90 citations

Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.

1996 • 76 citations

Isoelectric focusing subtypes of HLA-A can be defined by oligonucleotide typing

1993 • 74 citations

Chromosomal Structure of the Human TYRP1 and TYRP2 Loci and Comparison of the Tyrosinase-Related Protein Gene Family

1995 • 70 citations

Multiple Splicing Signals Control Alternative Intron Retention of Bovine Growth Hormone Pre-mRNA

1995 • 69 citations

Adoptive immunotherapy of advanced melanoma patients with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes selected in vitro with low doses of IL-2

1993 • 61 citations

Direct analysis of tumor-associated peptide antigens

1994 • 60 citations

MAGE-1 expression threshold for the lysis of melanoma cell lines by a specific cytotoxic T lymphocyte.

1997 • 48 citations

Functional heterogeneity of HLA-A*02 subtypes revealed by presentation of a MAGE-3-encoded peptide to cytotoxic T cell clones.

1997 • 40 citations

Incomplete Expression of the Tyrosinase Gene Family (Tyrosinase, TRP-1, and TRP-2) in Human Malignant Melanoma Cells In Vitro

1995 • 40 citations

Optimal T cell activation by melanoma cells depends on a minimal level of antigen transcription.

1997 • 36 citations

Functional heterogeneity of HLA-A*02 subtypes revealed by presentation of a MAGE-3-encoded peptide to cytotoxic T cell clones.

1997 • 35 citations

The two intervening sequences of human beta- and gamma-globin pre-mRNAs are excised in a preferred temporal order in vitro.

1985 • 28 citations

Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: A projected basis for immunotherapy

1997 • 22 citations