Does the Immune System See Tumors as Foreign or Self?

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

NK CELL RECEPTORS

1998 • 1,666 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Adoptive T cell therapy using antigen-specific CD8⁺T cell clones for the treatment of patients with metastatic melanoma:In vivopersistence, migration, and antitumor effect of transferred T cells

2002 • 1,187 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

2002 • 1,176 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Regulation of Cutaneous Malignancy by γδ T Cells

2001 • 945 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

2000 • 864 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

2002 • 634 citations

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumorin vivo

2001 • 588 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells

1988 • 522 citations

Loss of Functional Beta2-Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy

1996 • 515 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance

1995 • 478 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance

2002 • 448 citations

Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide–Based Vaccines

2002 • 426 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Spinning molecular immunology into successful immunotherapy

2002 • 364 citations

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

2002 • 363 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

1997 • 360 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors

1991 • 358 citations

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 • 358 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice

1974 • 328 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

1997 • 311 citations

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

2001 • 307 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

1999 • 287 citations

UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells

2002 • 272 citations

Multiple Genetic Alterations Cause Frequent and Heterogeneous Human Histocompatibility Leukocyte Antigen Class I Loss in Cervical Cancer

2000 • 270 citations

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1997 • 259 citations

Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression.

1983 • 251 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

1995 • 240 citations

Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.

1996 • 240 citations

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

2002 • 235 citations

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

1993 • 235 citations

Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes

1997 • 226 citations

Tumors of the Immunocompromised Patient

1988 • 221 citations

Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells

1989 • 215 citations

Cross-presentation of tumor antigens by bone marrow–derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

2001 • 214 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein‐Barr virus latent membrane protein‐1: coordinate up‐regulation of peptide transporters and HLA‐class I antigen expression

1995 • 205 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Heteroclitic Immunization Induces Tumor Immunity

1998 • 203 citations

Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.

1997 • 187 citations

Lymphoproliferative diseases in immunocompromised hosts: the role of Epstein-Barr virus.

1987 • 183 citations

Distribution of human Class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin.

1984 • 168 citations

Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4⁺ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

1996 • 165 citations

Immune selection after antigen-specific immunotherapy of melanoma

1999 • 162 citations

Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen

2000 • 160 citations

Fas Ligand Expression in Glioblastoma Cell Lines and Primary Astrocytic Brain Tumors

1997 • 153 citations

Selective changes in expression of HLA class I polymorphic determinants in human solid tumors.

1989 • 150 citations

Structural Features of Peptide Analogs of Human Histocompatibility Leukocyte Antigen Class I Epitopes That Are More Potent and Immunogenic than Wild-Type Peptide

2001 • 147 citations

Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma lesions.

1983 • 144 citations

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

1994 • 143 citations

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas

1998 • 143 citations

Mutations of the β₂‐microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

1998 • 142 citations

On the Role of Dendritic Cells in Peripheral T Cell Tolerance and Modulation of Autoimmunity

2002 • 140 citations

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells.

1982 • 135 citations

Human melanoma cells do not express Fas (Apo-1/CD95) ligand.

1999 • 133 citations

NK cell activation: distinct stimulatory pathways counterbalancing inhibitory signals

2000 • 130 citations

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

2002 • 129 citations

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions.

1996 • 128 citations

Immunity to Methylcholanthrene-Induced Tumours in Inbred Rats Following Atrophy and Regression of the Implanted Tumours

1955 • 123 citations

HER-2/neu and hTERT Cryptic Epitopes as Novel Targets for Broad Spectrum Tumor Immunotherapy

2002 • 121 citations

High frequency of altered HLA class I phenotypes in invasive breast carcinomas

1996 • 120 citations

Cellular and humoral aspects of the hypersensitive states : a symposium held at the New York academy of medicine

1959 • 110 citations

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

1984 • 109 citations

Postmodern cancer: the role of human immunodeficiency virus in uterine cervical cancer

2002 • 109 citations

Melanoma-associated expression of transforming growth factor-beta isoforms.

1996 • 107 citations

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS

1971 • 107 citations

Multiple tumour-specific antigens expressed on a single tumour cell

1983 • 107 citations

Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells.

1989 • 101 citations

Mouse tumor rejection antigens P815A and P815B : Two epitopes carried by a single peptide

1992 • 99 citations

The TCR δ Repertoire in Normal Human Skin is Restricted and Distinct from the TCR δ Repertoire in the Peripheral Blood

2001 • 94 citations

Comparative Analysis of the In Vivo Expression of Tyrosinase, MART-1/Melan-A, and gp100 in Metastatic Melanoma Lesions: Implications for Immunotherapy

1998 • 94 citations

Histocompatibility antigens in primary and metastatic squamous cell carcinoma of the larynx

1989 • 92 citations

Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression.

1996 • 92 citations

Spontaneous and induced tumor incidence in germfree "nude" mice.

1975 • 92 citations

The Nude Mouse vs. The Hypothesis of Immunological Surveillance

1976 • 91 citations

Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.

1990 • 91 citations

Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA.

1993 • 91 citations

Short-Term Kinetics of Tumor Antigen Expression in Response to Vaccination

2001 • 90 citations

Plurality of genital human papillomaviruses: Characterization of two new types with distinct biological properties

1987 • 90 citations

Manipulation of Avidity to Improve Effectiveness of Adoptively Transferred CD8+ T Cells for Melanoma Immunotherapy in Human MHC Class I-Transgenic Mice

2001 • 86 citations

Naive CD4⁺ T cells confer idiotype‐specific tumor resistance in the absence of antibodies

1995 • 86 citations

Phenotypic analysis and gamma delta-T cell receptor repertoire of murine T cells associated with the vaginal epithelium.

1991 • 85 citations

Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in anIn vitro melanoma model

1999 • 83 citations

Immunohistochemical analysis of HLA antigens and mononuclear infiltrates of benign and malignant breast

1987 • 77 citations

TGF-β: Receptors, Signaling Pathways and Autoimmunity

2001 • 77 citations

CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo

1999 • 76 citations

In situ expression of transforming growth factor ?? is associated with melanoma progression and correlates with Ki67, HLA-DR and ?? 3 integrin expression

1997 • 71 citations

Longevity of Antigen Presentation and Activation Status of APC Are Decisive Factors in the Balance Between CTL Immunity Versus Tolerance

2001 • 70 citations

HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas

1987 • 69 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen

2001 • 67 citations

Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx

1990 • 63 citations

The Ability of Variant Peptides to Reverse the Nonresponsiveness of T Lymphocytes to the Wild-Type Sequence p53264–272 Epitope

2002 • 62 citations

Direct analysis of tumor-associated peptide antigens

1994 • 60 citations

Modulation of B16 Melanoma Growth and Metastasis by Anti-Transforming Growth Factor ?? Antibody and Interleukin-2

1996 • 59 citations

The Expression of Histocompatibility-related Leukocyte Antigens in the Pathway to Cervical Carcinoma

1994 • 57 citations

Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma.

1985 • 57 citations

In situ analysis of transforming growth factor-βs (TGF-β1, TGF-β2, TGF-β3and TGF-3 type II receptor expression in malignant melanoma

1995 • 55 citations

Unmasking cryptic epitopes after loss of immunodominant tumor antigen expression through epitope spreading

2001 • 53 citations

Novel Role of Phosphatidylinositol 3-Kinase in CD28-mediated Costimulation

2001 • 51 citations

CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen

2001 • 50 citations

Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas.

2000 • 49 citations

HETEROGENEITY OF THE EXPRESSION OF CLASS I AND II HLA ANTIGENS IN HUMAN BREAST CARCINOMA

1986 • 47 citations

Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization.

2000 • 46 citations

Stepwise immunologic selection of antigenic variants during tumor growth.

1986 • 45 citations

Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase

1998 • 44 citations

Can the Low-Avidity Self-Specific T Cell Repertoire Be Exploited for Tumor Rejection?

2002 • 42 citations

On the front lines: intraepithelial lymphocytes as primary effectors of intestinal immunity

1997 • 42 citations

Phenotypic expression of histocompatibility antigens in human primary tumours and metastases

1989 • 37 citations

Survival and Cause of Death in Aging Germfree Athymic Nude and Normal Inbred C3Hf/He Mice2

1978 • 37 citations

Biologic aspects of human immunodeficiency virus-related lymphoma

1992 • 36 citations

Association of Allele-Specific HLA Expression and Histopathologic Progression of Cervical Carcinoma

1996 • 36 citations

Helicobacter pylori and gastric cancer

1997 • 34 citations

Cell cycle-dependent expression of TAP1, TAP2, and HLA-B27 messenger RNAs in a human breast cancer cell line.

1996 • 33 citations

Expression of gp 100 in Melanoma Metastases Resected Before or After Treatment with IFN?? and IL-2

1996 • 29 citations

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

1996 • 27 citations

Molecular analysis of MHC-class-I alterations in human tumor cell lines

1991 • 25 citations

Helicobacter pyloriand gastric cancer

1997 • 24 citations

γδ T Cells in Murine Epithelia: Origin, Repertoire, and Function

1991 • 20 citations

Lack of ignorance to tumor antigens: evaluation using nominal antigen transfection and T-cell receptor transgenic lymphocytes in Lyons-Parish analysis--implications for tumor tolerance.

2001 • 14 citations

Experiments and the concept of immunological surveillance

1976 • 9 citations