Description and prediction of peptide-MHC binding: the ‘human MHC project’

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Adaptive Computation and Machine Learning

2012 • 1,123 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

1994 • 345 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network.

1998 • 299 citations

Two complementary methods for predicting peptides binding major histocompatibility complex molecules

1997 • 261 citations

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.

1995 • 254 citations

MHCPEP, a database of MHC-binding peptides: update 1997

1998 • 213 citations

The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands

1993 • 196 citations

Bound Water Structure and Polymorphic Amino Acids Act Together to Allow the Binding of Different Peptides to MHC Class I HLA-B53

1996 • 162 citations

Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes from Mycobacterium tuberculosis and HIV protein sequences

1995 • 157 citations

Structural principles that govern the peptide-binding motifs of class I MHC molecules

1998 • 122 citations

Binding to Ia protects an immunogenic peptide from proteolytic degradation.

1989 • 113 citations

The MHC Class I-Restricted Immune Response to HIV-gag in BALB/c Mice Selects a Single Epitope That Does Not Have a Predictable MHC-Binding Motif and Binds to Kd Through Interactions Between a Glutamine at P3 and Pocket D

1998 • 103 citations

Molecular Dynamics Simulation of MHC-Peptide Complexes as a Tool for Predicting Potential T Cell Epitopes

1994 • 100 citations

Ranking potential binding peptides to MHC molecules by a computational threading approach

1995 • 100 citations

Peptide binding specificity of major histocompatibility complex class I resolved into an array of apparently independent subspecificities: quantitation by peptide libraries and improved prediction of binding

1996 • 99 citations

HLA class I region sequences, 1998

1998 • 95 citations

Prediction of binding to MHC class I molecules

1995 • 80 citations

A Structure-Based Algorithm to Predict Potential Binding Peptides to MHC Molecules with Hydrophobic Binding Pockets

1997 • 77 citations

Application of an artificial neural network to predict specific class I MHC binding peptide sequences

1998 • 74 citations

Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events.

1993 • 74 citations

Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models

1997 • 66 citations

Tolerance to Amino Acid Variations in Peptides Binding to the Major Histocompatibility Complex Class I Protein H-2Kb

1995 • 62 citations

HLA Class I Binding Motifs Derived from Random Peptide Libraries Differ at the COOH Terminus from Those of Eluted Peptides

1997 • 50 citations

Computational determination of side chain specificity for pockets in class I MHC molecules

1996 • 36 citations

A model of water structure inside the HLA-A2 peptide binding groove

1997 • 28 citations

Using a neural network to identify potential HLA‐DR1 binding sites within proteins

1993 • 21 citations

Role for MHC class I molecules in selecting and protecting high affinity peptides in the presence of proteases.

1994 • 20 citations

Stimulation of ciliary motility mediated by atypical β-adrenoceptor in canine bronchial epithelium

1993 • 19 citations

Amino Acid Preferences in the Octapeptide Subunit of the Major Histocompatibility Complex Class I Heterotrimer H‐2L^d

1996 • 16 citations

MHC class I-peptide interactions and TCR recognition.

1995 • 5 citations

An iterative algorithm for converting a class II MHC binding motif into a quantitative predictive model

1997 • 5 citations