Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

1999 • 619 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

A Rational Strategy to Design Multiepitope Immunogens Based on Multiple Th Lymphocyte Epitopes

2002 • 298 citations

Definition of specific peptide motifs for four major HLA-A alleles.

1994 • 282 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Two complementary methods for predicting peptides binding major histocompatibility complex molecules

1997 • 261 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

HLA supertypes and supermotifs: a functional perspective on HLA polymorphism

1998 • 244 citations

Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

1994 • 233 citations

Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

1997 • 210 citations

Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes

1999 • 166 citations

Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice

1998 • 164 citations

Structure‐based prediction of binding peptides to MHC class I molecules: Application to a broad range of MHC alleles

2000 • 155 citations

Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

2001 • 155 citations

Structural Features of Peptide Analogs of Human Histocompatibility Leukocyte Antigen Class I Epitopes That Are More Potent and Immunogenic than Wild-Type Peptide

2001 • 147 citations

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

1998 • 140 citations

Identification of New Epitopes from Four Different Tumor-Associated Antigens: Recognition of Naturally Processed Epitopes Correlates with HLA-A∗0201-Binding Affinity

2001 • 136 citations

Characterization of the specificity of peptide binding to four DR haplotypes.

1990 • 134 citations

Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules

2001 • 123 citations

Differences and similarities in the A2.1‐restricted cytotoxic T cell repertoire in humans and human leukocyte antigen‐transgenic mice

1996 • 119 citations

Identification and Antigenicity of Broadly Cross-Reactive and Conserved Human Immunodeficiency Virus Type 1-Derived Helper T-Lymphocyte Epitopes

2001 • 108 citations

Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime

1999 • 106 citations

The Development of Multi-epitope Vaccines: Epitope Identification, Vaccine Design and Clinical Evaluation

2001 • 103 citations

Effect of pH on MHC class II-peptide interactions.

1992 • 101 citations

A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen

1997 • 90 citations

Peptide binding to MHC class I molecules: Implications for antigenic peptide prediction

1995 • 81 citations

Immunodominance: intramolecular competition between T cell epitopes.

1991 • 77 citations

Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.

1997 • 73 citations

Identification of the Peptide Binding Motif for HLA-B44, One of the Most Common HLA-B Alleles in the Caucasian Population

1995 • 73 citations

Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35).

1998 • 71 citations

Assessment of Immunogenicity of Human Melan-A Peptide Analogues in HLA-A*0201/Kb Transgenic Mice

1999 • 65 citations

Sequence signals for generation of antigenic peptides by the proteasome: implications for proteasomal cleavage mechanism

2000 • 59 citations

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

1997 • 58 citations

Definition of the Mamu A*01 Peptide Binding Specificity: Application to the Identification of Wild-Type and Optimized Ligands from Simian Immunodeficiency Virus Regulatory Proteins

2000 • 53 citations

A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism.

1994 • 47 citations

The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope

1999 • 42 citations

Identification of Five Different Patr Class I Molecules That Bind HLA Supertype Peptides and Definition of Their Peptide Binding Motifs

2000 • 28 citations

HLA transgenic mice as models of human autoimmune diseases.

2000 • 25 citations

Silencing of immunodominant epitopes by contiguous sequences in complex synthetic peptides

1992 • 20 citations

Epitope identification and vaccine design for cancer immunotherapy.

2002 • 20 citations

HLA-binding peptides as a therapeutic approach for chronic HIV infection.

2000 • 6 citations