Genetic engineering of T cell specificity for immunotherapy of cancer

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Single-Chain Antigen-Binding Proteins

1988 • 1,450 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

1989 • 1,350 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

1992 • 684 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood Lymphocytes Confers Anti-Tumor Reactivity

1999 • 406 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 385 citations

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

2001 • 373 citations

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.

1998 • 357 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody

1985 • 339 citations

Expression of chimeric receptor composed of immunoglobulin-derived V resions and T-cell receptor-derived C regions

1987 • 335 citations

Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes

1998 • 309 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

1990 • 304 citations

The discovery of MHC restriction

1997 • 281 citations

Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.

1995 • 266 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

The ups and downs of T cell costimulation

1994 • 240 citations

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

1994 • 225 citations

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1987 • 220 citations

Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.

2000 • 215 citations

High-Avidity CTL Exploit Two Complementary Mechanisms to Provide Better Protection Against Viral Infection Than Low-Avidity CTL

2001 • 207 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 207 citations

Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors

1994 • 204 citations

Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.

1993 • 203 citations

The use of hybrid hybridomas to target human cytotoxic T lymphocytes

1987 • 199 citations

Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.

1994 • 198 citations

Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal Antibody

1995 • 194 citations

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

2000 • 171 citations

Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes

2000 • 169 citations

Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.

1996 • 155 citations

High-Efficiency Gene Transfer into Normal and Adenosine Deaminase-Deficient T Lymphocytes Is Mediated by Transduction on Recombinant Fibronectin Fragments

1998 • 124 citations

Antigen‐specific targeting of CD28‐mediated T cell co‐stimulation using chimeric single‐chain antibody variable fragment‐CD28 receptors

1996 • 122 citations

Recognition of Shared Melanoma Antigens in Association With Major HLA-A Alleles by Tumor Infiltrating T Lymphocytes From 123 Patients With Melanoma

2000 • 121 citations

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1–MAGE-A1 from a nonimmunized phage-Fab library

2000 • 119 citations

Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression.

1997 • 118 citations

T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.

2001 • 116 citations

Chimeric zeta-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes.

1995 • 112 citations

A retroviral vector system ‘STITCH’ in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes

1998 • 103 citations

Retroviral Transduction of a T Cell Receptor Specific for an Epstein–Barr Virus-Encoded Peptide

2001 • 100 citations

A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity.

1995 • 99 citations

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

2000 • 98 citations

Changing T cell specificity by retroviral T cell receptor display

2000 • 97 citations

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.

2002 • 97 citations

Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.

1995 • 94 citations

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity

2002 • 91 citations

Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex

2001 • 87 citations

CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

1995 • 85 citations

Redirected Perforin-Dependent Lysis of Colon Carcinoma by Ex Vivo Genetically Engineered CTL

2000 • 83 citations

Endowing T cells with antibody specificity using chimeric T cell receptors

1992 • 78 citations

New simplified molecular design for functional T cell receptor

1993 • 76 citations

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

2002 • 75 citations

A phage display selected Fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes

2001 • 74 citations

Functional three-domain single-chain T-cell receptors.

1994 • 74 citations

Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer

2002 • 69 citations

Adoptive Cellular Therapy

2004 • 67 citations

Harnessing Syk Family Tyrosine Kinases as Signaling Domains for Chimeric Single Chain of the Variable Domain Receptors: Optimal Design for T Cell Activation

1998 • 63 citations

A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimeric receptor gene recognizing a human ovarian cancer antigen

1998 • 58 citations

Impact of chimeric immune receptor extracellular protein domains on T cell function

1999 • 57 citations

Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor

1996 • 54 citations

Retargeting of a T cell line by anti MAGE-3/HLA-A2 alpha beta TCR gene transfer.

2000 • 52 citations

Coupling CD28 Co-Stimulation to Immunoglobulin T-Cell Receptor Molecules: The Dynamics of T-Cell Proliferation and Death

2000 • 50 citations

Adoptive Cellular Therapy

2010 • 48 citations

Recent advances in retrovirus vector-mediated gene therapy: teaching an old vector new tricks.

2001 • 48 citations

The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.

1999 • 48 citations

Chimeric scFv/γ receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules

1998 • 46 citations

The TCR ζ-Chain Immunoreceptor Tyrosine-Based Activation Motifs Are Sufficient for the Activation and Differentiation of Primary T Lymphocytes

1999 • 41 citations

Adoptive transfer of T-cell immunity

2002 • 36 citations

Display of functional αβ single-chain T-cell receptor molecules on the surface of bacteriophage

1998 • 31 citations

Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by cytotoxic T lymphocytes via CD3.

1993 • 31 citations

Retroviral-Mediated Gene Transfer in Primary Murine and Human T-Lymphocytes

2000 • 27 citations

IL-2 down-regulates the expression of TCR and TCR-associated surface molecules on CD8+ T cells

2001 • 23 citations

Immunologic recognition of malignant melanoma by autologous T lymphocytes

1993 • 23 citations

T Cells with Two Tcrβ Chains and Reactivity to both MHC/Idiotypic Peptide and Superantigen

1996 • 19 citations

Pharmacologic suppression of target cell recognition by engineered T cells expressing chimeric T-cell receptors

2000 • 9 citations

Preparation for a Phase I/II Study Using Autologous Gene Modified T Lymphocytes for Treatment of Metastatic Renal Cancer Patients

1998 • 9 citations