Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Expression profiling using cDNA microarrays

1999 • 1,689 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Laser Capture Microdissection: Molecular Analysis of Tissue

1997 • 890 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor

1997 • 746 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

Tumor antigens recognized by T cells

1997 • 552 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

1994 • 522 citations

Loss of Functional Beta2-Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy

1996 • 515 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9

1997 • 489 citations

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

1996 • 489 citations

Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance

1995 • 478 citations

Biologic Therapy of Cancer

1992 • 476 citations

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1996 • 452 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance

1998 • 430 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

1995 • 416 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Cancer vaccines based on the identification of genes encoding cancer regression antigens

1997 • 395 citations

Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability.

1996 • 389 citations

Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides.

1995 • 387 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

1997 • 360 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 • 358 citations

HLA : genetic diversity of HLA functional and medical implication

1997 • 354 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

1997 • 344 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

1997 • 319 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

1997 • 311 citations

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

1991 • 306 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1.

1995 • 296 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

T-cell epitope mapping by flow cytometry

1998 • 295 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

1996 • 290 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A.

1997 • 286 citations

Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity.

1991 • 281 citations

Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.

1994 • 276 citations

The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

1975 • 274 citations

Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variantsin vivo

1996 • 274 citations

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1996 • 272 citations

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen.

1996 • 261 citations

Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma.

1992 • 261 citations

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1997 • 259 citations

Tetrameric Complexes of Human Histocompatibility Leukocyte Antigen (HLA)-G Bind to Peripheral Blood Myelomonocytic Cells

1999 • 252 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression.

1983 • 251 citations

Down-Regulation of HLA Class I Antigen-Processing Molecules in Malignant Melanoma

1999 • 249 citations

c-myc down-regulates class I HLA expression in human melanomas.

1988 • 248 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

A novel role for TGF-beta and IL-10 in the induction of immune privilege.

1998 • 241 citations

Regulation of NK cell functions by TGF-beta 1.

1995 • 241 citations

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

1995 • 240 citations

Progressive Loss of H-2 Antigens With Concomitant Increase of Cell-Surface Antigen(s) Determined by Moloney Leukemia Virus in Cultured Murine Lymphomas23

1973 • 239 citations

Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

1997 • 239 citations

A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene.

1996 • 235 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig

1998 • 235 citations

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

1994 • 233 citations

Immunoreactivity for A103, an Antibody to Melan-A (Mart-1), in Adrenocortical and Other Steroid Tumors

1998 • 233 citations

Expression of Melan-A (MART1) in Benign Melanocytic Nevi and Primary Cutaneous Malignant Melanoma

1998 • 230 citations

Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells.

1991 • 227 citations

Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection

1995 • 225 citations

Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens.

1989 • 223 citations

Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

1996 • 222 citations

Hypomethylation of DNA in pathological conditions of the human prostate.

1987 • 219 citations

Reversal of tumor-induced immunosuppression: a new approach to cancer therapy.

1997 • 219 citations

Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides.

1996 • 215 citations

Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1.

1995 • 214 citations

Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.

1995 • 213 citations

Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens.

1981 • 213 citations

Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes.

1995 • 208 citations

A Breast and Melanoma-Shared Tumor Antigen: T Cell Responses to Antigenic Peptides Translated from Different Open Reading Frames

1998 • 208 citations

Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.

1996 • 208 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

1996 • 206 citations

Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein‐Barr virus latent membrane protein‐1: coordinate up‐regulation of peptide transporters and HLA‐class I antigen expression

1995 • 205 citations

Localization of111Indium-labeled tumor infiltrating lymphocytes to tumor in patients receiving adoptive immunotherapy. Augmentation with cyclophosphamide and correlation with response

1994 • 201 citations

Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2).

1998 • 199 citations

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer

1996 • 196 citations

beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.

1998 • 193 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

Loss of HLA class I expression in prostate cancer: Implications for immunotherapy

1995 • 189 citations

Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.

1997 • 187 citations

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.

1988 • 186 citations

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer

1996 • 186 citations

Loss of MHC class‐I expression in cervical carcinomas

1990 • 184 citations

Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35).

1996 • 182 citations

Reversal of Tumor-Induced Immunosuppression: A New Approach to Cancer Therapy

1997 • 182 citations

Vascular Adhesion Protein-1 and ICAM-1 Support the Adhesion of Tumor-Infiltrating Lymphocytes to Tumor Endothelium in Human Hepatocellular Carcinoma

1998 • 181 citations

A Novel Role for TGF-β and IL-10 in the Induction of Immune Privilege

1998 • 178 citations

Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.

1995 • 177 citations

Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes

1991 • 176 citations

Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.

1993 • 176 citations

HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions.

1998 • 175 citations

Tumor progression in human malignant melanoma: Five stages defined by their antigenic phenotypes

1987 • 173 citations

Frequency of down-regulation of individual HLA-A and -B alleles in cervical carcinomas in relation to TAP-1 expression

1995 • 172 citations

Phenotypic dynamics of tumor progression in human malignant melanoma

1985 • 172 citations

Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms.

1992 • 170 citations

Quantification of cytokine mRNA expression by RT PCR in samples of previously frozen blood

1997 • 169 citations

Distribution of human Class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin.

1984 • 168 citations

Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes.

1995 • 166 citations

Heterogeneous expression of melanoma-associated antigens and HLA-A2 in metastatic melanoma in vivo

1998 • 166 citations

Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas.

1988 • 163 citations

Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

1994 • 163 citations

Immune selection after antigen-specific immunotherapy of melanoma

1999 • 162 citations

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

1995 • 161 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

1997 • 159 citations

Follow the Leader: NK Cell Receptors for Classical and Nonclassical MHC Class I

1998 • 156 citations

Fas Ligand Expression in Glioblastoma Cell Lines and Primary Astrocytic Brain Tumors

1997 • 153 citations

Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.

1977 • 151 citations

Selective changes in expression of HLA class I polymorphic determinants in human solid tumors.

1989 • 150 citations

Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens.

1984 • 149 citations

Differential expression of H–2 gene products in tumour cells is associated with their metastatogenic properties

1980 • 146 citations

Tumor Immunology

1998 • 146 citations

Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.

1995 • 145 citations

Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma lesions.

1983 • 144 citations

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

1994 • 143 citations

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas

1998 • 143 citations

A monoclonal antibody specific for cells of the melanocyte lineage.

1988 • 143 citations

Mutations of the β₂‐microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

1998 • 142 citations

A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma.

1996 • 142 citations

Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage

1998 • 141 citations

HLA-DR Antigen Expression in Primary Melanomas of the Skin

1984 • 140 citations

Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells

1997 • 139 citations

Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on human tumor cells is required for their interaction with autologous lymphocytes in vitro

1990 • 139 citations

Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours

1994 • 138 citations

Limit of T Cell Tolerance to Self Proteins by Peptide Presentation

1990 • 138 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Further evidence for derepression of H–2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines

1976 • 138 citations

Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in metastatic versus primary breast cancer.

1995 • 137 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Loss of HLA‐A,B,C and de novo expression of HLA‐D in colorectal cancer

1986 • 136 citations

Level of HLA antigens in locoregional metastases and clinical course of the disease in patients with melanoma.

1988 • 136 citations

A tyrosinase nonapeptide presented by HLA‐B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes

1996 • 135 citations

Immunohistochemical correlates of response to recombinant interleukin-2-based immunotherapy in humans.

1989 • 134 citations

Human melanoma cells do not express Fas (Apo-1/CD95) ligand.

1999 • 133 citations

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

1983 • 131 citations

Analysis of Expression of the Melanoma-Associated Antigens MART-1 and gp lOO in Metastatic Melanoma Cell Lines and in In Situ Lesions

1996 • 131 citations

Selection for β2-microglobulin mutation in mismatch repair-defective colorectal carcinomas

1996 • 130 citations

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions.

1996 • 128 citations

HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas

1989 • 127 citations

QUANTITATIVE STUDIES OF THE SENSITIVITY OF NORMAL AND NEOPLASTIC MOUSE CELLS TO THE CYTOTOXIC ACTION OF ISOANTIBODIES

1962 • 127 citations

Differential Anti-MART-1/MelanA CTL Activity in Peripheral Blood of HLA-A2 Melanoma Patients in Comparison to Healthy Donors

1996 • 127 citations

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells.

1993 • 127 citations

Functional Dissociation Between Local and Systemic Immune Response During Anti-Melanoma Peptide Vaccination

1998 • 127 citations

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition

1999 • 126 citations

Prolonged Upregulation of the Expression of HLA Class I Antigens and Co stimulatory Molecules on Melanoma Cells Treated with 5-aza-2??-deoxycytidine (5-AZA-CdR)

1999 • 126 citations

Human Tumor Antigens

1987 • 126 citations

Analysis of MHC class I and II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions

1993 • 125 citations

CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.

1995 • 124 citations

Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.

1996 • 123 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides.

1995 • 121 citations

The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma-reactive tumor-infiltrating lymphocytes.

1997 • 121 citations

High frequency of altered HLA class I phenotypes in invasive breast carcinomas

1996 • 120 citations

Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

1989 • 119 citations

Accumulation of the p53 Protein Allows Recognition by Human CTL of a Wild-Type p53 Epitope Presented by Breast Carcinomas and Melanomas

1998 • 118 citations

Down-regulation of the transporter for antigen presentation, proteasome subunits, and class I major histocompatibility complex in tumor cell lines.

1998 • 117 citations

Expression of H-2 and Moloney Leukemia Virus-Determined Cell-Surface Antigens in Synchronized Cultures of a Mouse Cell Line

1971 • 117 citations

MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.

1991 • 116 citations

Melanoma Antigens: Immunological and Biological Characterization and Clinical Significance

1988 • 116 citations

Biochemical characterization and cellular localization of a formalin-resistant melanoma-associated antigen reacting with monoclonal antibody NKI/C-3

1985 • 115 citations

Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles

1998 • 114 citations

The RFX Complex Is Crucial for the Constitutive and CIITA-Mediated Transactivation of MHC Class I and β2-Microglobulin Genes

1998 • 113 citations

Suppression of class I human histocompatibility leukocyte antigen by c-myc is locus specific.

1989 • 112 citations

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

1994 • 112 citations

MHC antigens in human melanomas.

1991 • 111 citations

The role of enhancer A in the locus-specific transactivation of classical and nonclassical HLA class I genes by nuclear factor kappa B.

1998 • 110 citations

Natural killer cell lines kill autologous β₂-microglobulin-deficient melanoma cells: Implications for cancer immunotherapy

1997 • 109 citations

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

1984 • 109 citations

The differential expression of H‐2K versus H‐2D antigens, distinguishing high‐ metastatic from low‐ metastatic clones, is correlated with the immunogenic properties of the tumor cells

1984 • 108 citations

Melanoma-associated expression of transforming growth factor-beta isoforms.

1996 • 107 citations

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS

1971 • 107 citations

Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.

1996 • 106 citations

Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions

1996 • 105 citations

Tumor Necrosis Factor β and Ultraviolet Radiation Are Potent Regulators of Human Keratinocyte ICAM-1 Expression

1990 • 104 citations

Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells.

1993 • 104 citations

Selective Histocompatibility Leukocyte Antigen (Hla)-A2 Loss Caused by Aberrant Pre-mRNA Splicing in 624mel28 Melanoma Cells

1999 • 104 citations

Cytokine-induced enhancement of ICAM-1 expression results in increased vulnerability of tumor cells to monocyte-mediated lysis.

1991 • 103 citations

Production of recombinant MART-1 proteins and specific antiMART-1 polyclonal and monoclonal antibodies: use in the characterization of the human melanoma antigen MART-1

1997 • 102 citations

Molecular Biology of Chromosome Function

1989 • 101 citations

Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma.

1989 • 101 citations

Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer.

1994 • 100 citations

Mouse tumor rejection antigens P815A and P815B : Two epitopes carried by a single peptide

1992 • 99 citations

MHC class I and II expression in prostate carcinoma and modulation by interferon-alpha and -gamma

1997 • 97 citations

Suppression of MHC class I gene expression by N-myc through enhancer inactivation.

1989 • 94 citations

Comparative Analysis of the In Vivo Expression of Tyrosinase, MART-1/Melan-A, and gp100 in Metastatic Melanoma Lesions: Implications for Immunotherapy

1998 • 94 citations

Histocompatibility antigens in primary and metastatic squamous cell carcinoma of the larynx

1989 • 92 citations

The Role of Enhancer A in the Locus-Specific Transactivation of Classical and Nonclassical HLA Class I Genes by Nuclear Factor κB

1998 • 92 citations

Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression.

1996 • 92 citations

Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA.

1993 • 91 citations

HLA‐G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex

1997 • 90 citations

Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb gene.

1988 • 86 citations

Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line

1996 • 85 citations

Human Melanoma-Reactive CD4+ and CD8+ CTL Clones Resist Fas Ligand-Induced Apoptosis and Use Fas/Fas Ligand-Independent Mechanisms for Tumor Killing

1998 • 83 citations

Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in anIn vitro melanoma model

1999 • 83 citations

Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer

1998 • 83 citations

Multiple receptors for HLA-G on human natural killer cells

1997 • 82 citations

Expression of major histocompatibility antigens and nature of inflammatory cellular infiltrate in ovarian neoplasms

1983 • 81 citations

Cytokine‐mediated modulation of HLA‐class II, ICAM‐1, LFA‐3 and tumor‐associated antigen profile of melanoma cells. comparison with anti‐proliferative activity by RIL1‐β, RTNF‐α, RIFN‐γ, RIl4 and their combinations

1990 • 81 citations

MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4+ T Lymphocytes1

1998 • 81 citations

Generation of tumor-specific CTLs from melanoma patients by using peripheral blood stimulated with allogeneic melanoma tumor cell lines. Fine specificity and MART-1 melanoma antigen recognition.

1995 • 81 citations

Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma

1996 • 80 citations

Natural inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions.

1997 • 80 citations

Reduced expression of HLA class I and II antigens in colon cancer.

1990 • 80 citations

Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.

1996 • 80 citations

Immunohistochemical analysis of HLA antigens and mononuclear infiltrates of benign and malignant breast

1987 • 77 citations

Association of HER2/neu expression with sensitivity to tumor-specific CTL in human ovarian cancer.

1994 • 76 citations

Epidermal Interferon-γ Inducible Protein-10 (IP-10) and Monokine Induced by γ-Interferon (Mig) but not IL-8 mRNA Expression is Associated with Epidermotropism in Cutaneous T Cell Lymphomas

1998 • 75 citations

Expression of HLA class I and II antigens in bronchogenic carcinomas: its relationship to cellular DNA content and clinical-pathological parameters.

1991 • 74 citations

N-myc suppresses major histocompatibility complex class I gene expression through down-regulation of the p50 subunit of NF-kappa B.

1993 • 72 citations

Identification of tumour rejection antigens recognized by T lymphocytes.

1992 • 72 citations

In situ expression of transforming growth factor ?? is associated with melanoma progression and correlates with Ki67, HLA-DR and ?? 3 integrin expression

1997 • 71 citations

Minimal requirements for peptide mediated activation of CD8+ CTL

1994 • 71 citations

Transcriptional regulation of HLA-A and -B: differential binding of members of the Rel and IRF families of transcription factors.

1993 • 71 citations

Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35).

1998 • 71 citations

Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma.

1991 • 70 citations

HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas

1987 • 69 citations

Loss of a unique tumor antigen by cytotoxic T lymphocyte immunoselection from a 3-methylcholanthrene-induced mouse sarcoma reveals secondary unique and shared antigens.

1996 • 68 citations

IL2 treatment for cancer: from biology to gene therapy

1992 • 68 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

Circulating MELAN-A/MART-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype

1998 • 67 citations

The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles

1998 • 67 citations

Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene.

1991 • 65 citations

Clonal deletion of thymocytes as a tumor escape mechanism

1998 • 65 citations

Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx

1990 • 63 citations

An immunohistochemical study of altered immunomodulatory molecule expression in head and neck squamous cell carcinoma

1997 • 63 citations

Expression of HLA-A2 antigen in human melanoma cell lines and its role in T-cell recognition.

1991 • 63 citations

H‐2K^b TRANSFECTION OF B16 MELANOMA CELLS RESULTS IN REDUCED TUMOURIGENICITY AND METASTATIC COMPETENCE

1989 • 63 citations

A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.

1993 • 62 citations

Overlapping peptides of melanocyte differentiation antigen melan-A/MART-1 recognized by autologous cytolytic T lymphocytes in association with HLA-B45.1 and HLA-A2.1

1998 • 62 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

Expression of the adhesion molecule ICAM-1 in non-Hodgkin's lymphoma: relationship with tumor dissemination and prognostic importance.

1998 • 60 citations

Modulation of B16 Melanoma Growth and Metastasis by Anti-Transforming Growth Factor ?? Antibody and Interleukin-2

1996 • 59 citations

Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells.

1997 • 58 citations

Immunodominance in the immune response to ?multiple? histocompatibility antigens

1982 • 58 citations

The Expression of Histocompatibility-related Leukocyte Antigens in the Pathway to Cervical Carcinoma

1994 • 57 citations

Heterogeneity of HLA-A,B, Ia-like, and melanoma-associated antigen expression by human melanoma cell lines analyzed with monoclonal antibodies and flow cytometry.

1982 • 57 citations

Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma.

1985 • 57 citations

Stringent Allele/Epitope Requirements for MART-1/Melan A Immunodominance: Implications for Peptide-Based Immunotherapy

1998 • 56 citations

Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen

1988 • 56 citations

Can the HLA phenotype be used as a prognostic factor in breast carcinomas?

1991 • 56 citations

Locus-specific transcriptional control of HLA genes.

1992 • 55 citations

In situ analysis of transforming growth factor-βs (TGF-β1, TGF-β2, TGF-β3and TGF-3 type II receptor expression in malignant melanoma

1995 • 55 citations

Locus-Specific Analysis of Human Leukocyte Antigen Class I Expression in Melanoma Cell Lines

1994 • 55 citations

Expression of major histocompatibility class I and class II antigens and intercellular adhesion molecule-1 on operable non-small cell lung carcinomas: Frequency and prognostic significance

1994 • 54 citations

Development of tumor cell resistance to syngeneic cell-mediated cytotoxicity during growth of ascitic mastocytoma P815Y.

1977 • 54 citations

In vivo sensitivity of human melanoma to tumor necrosis factor (TNF)-alpha is determined by tumor production of the novel cytokine endothelial-monocyte activating polypeptide II (EMAPII).

1999 • 53 citations

DNA binding of regulatory factors interacting with MHC-class-I gene enhancer correlates with MHC-class-I transcriptional level in class-I-defective cell lines

1991 • 53 citations

Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.

1997 • 51 citations

Recognition of simian virus 40 T antigen by cytotoxic T lymphocytes.

1990 • 51 citations

Differential central nervous system responses folloqing single and multiple recombinant interleukin-2 infusions

1990 • 51 citations

Expression of Fas(APO-1/CD95) in tumor-infiltrating and peripheral blood lymphocytes in patients with renal cell carcinoma.

1998 • 51 citations

NK-cell receptors and recognition of MHC class I molecules

1996 • 51 citations

Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface.

1992 • 50 citations

Lacking prognostic significance of β2-microglobulin, MHC class I and class II antigen expression in breast carcinomas

1990 • 50 citations

Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide

1989 • 50 citations

Relationship Between myc Oncogene Activation and MHC Class I Expression

1992 • 49 citations

Local Expression of Cytokines in Human Colorectal Carcinoma: Evidence of Specific Interleukin-6 Gene Expression

1999 • 49 citations

High expression of the c-myc oncogene renders melanoma cells prone to lysis by natural killer cells.

1989 • 49 citations

MAGE-1 expression threshold for the lysis of melanoma cell lines by a specific cytotoxic T lymphocyte.

1997 • 48 citations

Altered HLA Expression by Metastatic Cervical Carcinoma Cells as a Factor in Impaired Immune Surveillance

1995 • 48 citations

HETEROGENEITY OF THE EXPRESSION OF CLASS I AND II HLA ANTIGENS IN HUMAN BREAST CARCINOMA

1986 • 47 citations

Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage

1997 • 47 citations

HLA class I expression and HPV‐16 sequences in premalignant and malignant lesions of the cervix

1993 • 47 citations

Antigenic heterogeneity of clones and subclones from human melanoma cell lines demonstrated by a panel of monoclonal antibodies and flow microfluorometry analysis

1984 • 46 citations

HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines

1998 • 46 citations

Loss of monomorphic and polymorphic HLA antigens in metastatic breast and colon carcinoma

1991 • 46 citations

Natural killer susceptibility is independent of HLA class I antigen expression on cell lines obtained from human solid tumors

1990 • 46 citations

Major Histocompatibility Complex Class I and Class II Expression in Renal Cell Carcinoma and Modulation by Interferon Gamma

1996 • 46 citations

Expression of MHC molecules and ICAM-1 on non-small cell lung carcinomas: Association with early lymphatic spread of tumour cells

1996 • 46 citations

Selective loss of human leukocyte antigen class I allele expression in advanced renal cell carcinoma.

1996 • 45 citations

Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines

1996 • 45 citations

Stepwise immunologic selection of antigenic variants during tumor growth.

1986 • 45 citations

HL-A Antigenic Loss in Malignant Transformation<xref ref-type="fn" rid="FN2">2</xref>

1971 • 44 citations

Biological‐clinical significance of selective loss of HLA‐class‐I allelic product expression in squamous‐cell carcinoma of the uterine cervix

1994 • 43 citations

A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA‐A*01 allele

1997 • 43 citations

An improved method for construction of directionally cloned cDNA libraries from microdissected cells.

1998 • 43 citations

Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells?

1998 • 42 citations

Monoclonal antibody-based therapy

1996 • 42 citations

Regional immunosuppression in esophageal squamous cancer: evidence from functional studies with matched lymph nodes.

1996 • 41 citations

Immunohistological evaluation of MHC class I and II antigen expression on nevi and melanoma: relation to biology of melanoma

1987 • 41 citations

Modulated expression of human leucocyte antigen class I and class II determinants in hyperplastics and malignant human prostatic epithelium

1994 • 40 citations

Molecular and functional phenotypes of melanoma cells with abnormalities in HLA Class I antigen expression

1996 • 40 citations

In situ analysis of transforming growth factors-beta (TGF-beta 1, TGF-beta 2, TGF-beta 3) and TGF-beta type II receptor expression in basal cell carcinomas.

1996 • 40 citations

HLA antigen expression in routinely processed head and neck squamous cell carcinoma primary lesions of different sites

1991 • 39 citations

MHC class I expression in HPV 16 positive cervical carcinomas is post-transcriptionally controlled and independent from c-myc overexpression.

1993 • 38 citations

Immunodominance Across HLA Polymorphism: Implications for Cancer Immunotherapy

1998 • 38 citations

Phenotypic expression of histocompatibility antigens in human primary tumours and metastases

1989 • 37 citations

Stable inheritance of an HLA‐“blank' phenotype associated with a structural mutation in the HLA‐A*0301 gene

1996 • 37 citations

Association of Allele-Specific HLA Expression and Histopathologic Progression of Cervical Carcinoma

1996 • 36 citations

Quantitation of MHC antigen expression on colorectal tumours and its association with tumour progression

1987 • 36 citations

Transcriptional suppression of HLA-B expression by c-Myc is mediated through the core promoter elements

1994 • 36 citations

Loss of polymorphic A and B locus HLA antigens in colon carcinoma

1988 • 36 citations

Immunohistochemical detection of major histocompatibility complex antigens and quantitative analysis of tumour-infiltrating mononuclear cells in renal cell cancer

1990 • 35 citations

A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes.

1990 • 35 citations

Decreased expression of ICAM-1 and its induction by tumor necrosis factor on breast-cancer cellsin vitro

1997 • 35 citations

Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo.

1987 • 35 citations

Immunodominant deters the response to other tumor antigens thereby favoring escape: prevention by vaccination with tumor variants selected with cloned cytolytic T cells in vitro

1996 • 34 citations

Expression of class I histocompatibility antigens in neuroectodermal tumors is independent of the expression of a transfected neuroblastoma myc gene.

1989 • 34 citations

Profile of intercellular adhesion molecule-1 (ICAM-1) synthesized by human melanoma cell lines.

1988 • 34 citations

Expression of HLA‐A, B, C, β₂‐microglobulin (β₂m), HLA‐DR, ‐DP, ‐DQ and of HLA‐D‐associated invariant chain (Ii) in soft‐tissue tumors

1990 • 33 citations

Reduced tumorigenicity of a spontaneous mouse lung carcinoma following H-2 gene transfection.

1987 • 33 citations

HLA Class I and Class II Antigen Expression on Squamous Cell Carcinoma of the Head and Neck

1990 • 33 citations

Cell cycle-dependent expression of TAP1, TAP2, and HLA-B27 messenger RNAs in a human breast cancer cell line.

1996 • 33 citations

Altered HLA class I expression in non-small cell lung cancer is independent of c-myc activation

1992 • 32 citations

Further Studies on Isoantigenic Variation in Mouse Carcinomas and Sarcomas&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1960 • 32 citations

Induction of Inflammatory Cytokines in Effusion Cavity by OK-432 Injection Therapy for Patients with Malignant Effusion: Role of Interferon-γ in Enhancement of Surface Expression of ICAM-1 on Tumor Cellsin Vivo

1996 • 32 citations

Differential modulation by tumor necrosis factor and immune interferon of HLA class‐II antigens expressed by melanoma cells

1989 • 31 citations

Tumor Necrosis Factor Alpha (TNFα)‐Induced ICAM‐1 Surface Expression in Airway Epithelial Cells in vitro: Possible Signal Transduction Mechanisms^a

1996 • 31 citations

Expression of MHC class I and class II antigens in primary breast carcinomas and synchronous nodal metastases

1995 • 30 citations

Studies on Isoantigenic Variation in Mouse Lymphomas&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1960 • 29 citations

Expression of gp 100 in Melanoma Metastases Resected Before or After Treatment with IFN?? and IL-2

1996 • 29 citations

Reduction of major histocompatibility complex class I antigens on invasive and high‐grade transitional cell carcinoma

1990 • 29 citations

Evidence for self and nonself peptide partial agonists that prolong clonal survival of mature T cells in vitro.

1997 • 29 citations

The Role of ICAM-1 in Tumor Development

1991 • 28 citations

Characterization of antigenic peptides presented by HLA-B44 molecules on tumor cells expressing the geneMAGE-3

1996 • 28 citations

Pecking order among tumor‐specific antigens

1984 • 28 citations

Expression of CD44, ICAM-1 and N-CAM in colorectal cancer. Correlation with the tumor stage and the phenotypical characteristics of tumor-infiltrating lymphocytes.

1997 • 28 citations

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

1996 • 27 citations

A decapeptide (Gln-Asp-Leu-Thr-Met-Lys-Tyr-Gln-Ile-Phe) from human melanoma is recognized by CTL in melanoma patients.

1994 • 27 citations

MAGE-1 expression threshold for the lysis of melanoma cell lines by a specific cytotoxic T lymphocyte

1997 • 27 citations

ABSENCE OF FOUR H‐2^d ANTIGENIC SPECIFICITIES IN AN H‐2^d SARCOMA

1979 • 26 citations

??2-Microglobulin gene mutations in human melanoma cells

1997 • 26 citations

Enhanced Cytolytic Activity of Tumor Infiltrating Lymphocytes (TILs) Derived from an ICAM-1 Transfected Tumor in a Murine Model

1998 • 26 citations

Molecular analysis of MHC-class-I alterations in human tumor cell lines

1991 • 25 citations

MHC CLASS I AND II ANTIGENS ON GASTRIC CARCINOMAS AND AUTOLOGOUS MUCOSA

1989 • 25 citations

The Expression of HLA Class I Antigens in Germ Cell Testicular Cancer

1990 • 24 citations

Interferon γ (IFNγ) gene transfer of an EMT6 tumor that is poorly responsive to IFNγ stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC

1996 • 23 citations

Expression of the adhesion molecules ICAM‐1 and ICAM‐2 on tumor cell lines does not correlate with their susceptibility to natural killer cell‐mediated cytolysis: evidence for additional ligands for effector cell β₂ integrins

1992 • 23 citations

MHC Class II-Mediated Antigen Presentation by Melanoma Cells

1996 • 23 citations

Frequency and relative fraction of tumor antigen-specific T cells among lymphocytes from melanoma-invaded lymph nodes

1998 • 22 citations

Cross-Presentation of Self Antigens to CD8+ T Cells: The Balance Between Tolerance and Autoimmunity

2007 • 21 citations

ChemInform Abstract: HLA and Cancer: 12^th International Histocompatibility Workshop Study

2000 • 21 citations

Immunologic analysis : recent progress in diagnostic laboratory immunology

1982 • 21 citations

Re‐expression of major histocompatibility complex (UMHC) class I molecules on malignant tumor cells and its effect on host‐tumor interaction

1989 • 20 citations

MHC class I antigen expression is inversely related with tumor malignancy and ras oncogene product (p21ras) levels in human breast tumors.

1992 • 19 citations

Fibrinolytic activity of ascites caused by alcoholic cirrhosis and peritoneal malignancy.

1993 • 18 citations

Role of LFA-3, ICAM-1, and MHC Class I on the Sensitivity of Human Tumor Cells to LAK Cells

1996 • 18 citations

MHC class I genes controlling the metastatic phenotype of tumor cells.

1991 • 17 citations

Loss of HLA Heavy Chain and β2‐Microglobulin in HLA Negative Tumours

1991 • 17 citations

Characteristics of MHC antigen expression and tumor-infiltrating mononuclear cells in renal cell adenomas and carcinomas.

1995 • 17 citations

Activation or frustration of anti-tumor responses by T-cell-based immune modulation

1997 • 15 citations

Low Frequency of ErbB-2 Proto-oncogene Overexpression in Human Leukocyte Antigen-A2-Positive Breast Cancer Patients

1997 • 15 citations

Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?

1995 • 15 citations

Combination Therapy with Interferon-γ and Interleukin-2 for the Treatment of Metastatic Melanoma

1996 • 15 citations

Immunohistological characteristics of the infiltrating lymphoid cells and expression of HLA class I and II antigens in nasopharyngeal carcinoma

1990 • 15 citations

Human Melanoma-Associated Antigens

2020 • 14 citations

VARIATIONS IN EXPRESSION OF SURFACE ANTIGENS ON CULTURED CELLS*

1971 • 13 citations

Expression of HLA Class-1 Antigens on Renal Cell Carcinoma and Non-Transformed Renal Tissue

1992 • 12 citations

The SV40 Large Tumor Antigen

1989 • 12 citations

Immunohistochemical Studies on the Expression of HLA Class I Antigens in Renal Cell Carcinoma: Comparison of Primary and Metastatic Tumor Tissue

1994 • 12 citations

Involvement of MHC class I molecule and ICAM-1 in the enhancement of adhesion and cytotoxic susceptibility to immune effector cells of tumor cells transfected with the interleukin (IL)-2, IL-4 or IL-6 gene

1997 • 12 citations

β 2 Microglobulin Expression in Normal Melanocytes, Nevocellular Nevi, and Malignant Melanomas

1989 • 11 citations

Changes in HLA, A,B,C expression during “spontaneous” transformation of human urothelial cells in vitro

1987 • 10 citations

Modulation by cytokines of HLA antigens, intercellular adhesion molecule 1 and high molecular weight melanoma associated antigen expression and of immune lysis of clones derived from the melanoma cell line MeM 50-10

1989 • 9 citations

Sertoli cells, but not tumor cells, of seminoma in situ express ICAM‐1

1996 • 8 citations

Antigenic Changes of DBA/2J Mastocytoma Cells When Grown in the BALB/c Mouse2

1977 • 8 citations

Differential transcription inducibility by interferon of the HLA-A3 and HLA-B7 class-I genes

1991 • 7 citations

In situ analysis of transforming growth factors-β(TGF-β1, TGG-β2, TGF-β3) and TGF-β type II receptor expression in basal cell carcinomas

1996 • 7 citations

beta2 Microglobulin Expression in Normal Melanocytes, Nevocellular Nevi, and Malignant Melanomas.

1989 • 6 citations

Commentary

1996 • 3 citations

Interleukin-8 receptor antagonists

1998 • 2 citations

Functional class II antigen presentation pathway in metastatic melanoma cell lines.

1996 • 1 citations