Specific Proteolytic Cleavages Limit the Diversity of the Pool of Peptides Available to MHC Class I Molecules in Living Cells

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

1997 • 528 citations

Exact prediction of a natural T cell epitope

1991 • 455 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

LacZ inducible, antigen/MHC-specific T cell hybrids

1994 • 377 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing

1994 • 300 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

1997 • 267 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly

1998 • 237 citations

Identification of T-Cell Epitopes

1993 • 232 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

1994 • 222 citations

MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL.

1997 • 207 citations

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex

1998 • 188 citations

Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells.

1993 • 185 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

1995 • 155 citations

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

1992 • 155 citations

A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules

1998 • 144 citations

A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL

1996 • 139 citations

Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

1993 • 128 citations

Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol

1998 • 124 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

The Rat cim Effect: TAP Allele-Dependent Changes in a Class I MHC Anchor Motif and Evidence Against C-Terminal Trimming of Peptides in the ER

1996 • 117 citations

Isolation and partial characterization of an acid carboxypeptidase from yeast

1974 • 114 citations

The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

1997 • 108 citations

Substrate specificity of allelic variants of the TAP peptide transporter

1994 • 95 citations

Allelic Differences in the Relationship Between Proteasome Activity and MHC Class I Peptide Loading

1998 • 75 citations

How Selective Is the Transporter Associated with Antigen Processing?

1996 • 72 citations

Presentation of endogenous peptide/MHC class I complexes is profoundly influenced by specific C-terminal flanking residues.

1995 • 57 citations

Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein

1998 • 55 citations

Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.

1997 • 52 citations

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.

1994 • 48 citations

Ovalbumin utilizes an NH2-terminal signal sequence.

1982 • 45 citations

The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

1995 • 41 citations

Murine Transporter Associated with Antigen Presentation (TAP) Preferences Influence Class I–restricted T Cell Responses

1997 • 32 citations

A unique carboxypeptidase activity of yeast proteinase C

1970 • 30 citations

Reading within the lines: naturally processed peptides displayed by MHC class I molecules

1998 • 14 citations