Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Molecular biology of the cell

1993 • 2,383 citations

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

1997 • 1,855 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

An evolutionary perspective on synonymous codon usage in unicellular organisms

1986 • 874 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages

2002 • 682 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Protein degradation and the generation of MHC class I-presented peptides

2002 • 340 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

2003 • 298 citations

Quantitation of parameters that determine the rate of ovalbumin synthesis

1975 • 289 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

Detecting and Measuring Cotranslational Protein Degradation in Vivo

2000 • 247 citations

Intracellular Localization of Proteasomal Degradation of a Viral Antigen

1999 • 214 citations

Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits

1997 • 181 citations

A channeled tRNA cycle during mammalian protein synthesis.

1995 • 148 citations

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

2001 • 147 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

Cutting Edge: Neosynthesis Is Required for the Presentation of a T Cell Epitope from a Long-Lived Viral Protein

2001 • 101 citations

Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.

1996 • 99 citations

At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules

2001 • 90 citations

Translation rate modification by preferential codon usage: Intragenic position effects

1987 • 81 citations

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

1998 • 64 citations

ConA induced changes in energy metabolism of rat thymocytes

1992 • 45 citations

The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

1995 • 41 citations

Intracellular Rate-Limiting Steps in MHC Class I Antigen Processing

1999 • 40 citations

Antigen Secreted from Noncytosolic Listeria monocytogenes Is Processed by the Classical MHC Class I Processing Pathway

1999 • 24 citations

An excess of the small ribosomal subunits and a higher rate of turnover of the 60 S than of the 40 S ribosomal subunits in L cells grown in suspension culture

1976 • 15 citations

Protein turnover in relation to growth status and the cell cycle in cultured mammalian cells.

1989 • 4 citations