Proteome analysis and its impact on the discovery of serological tumor markers

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

1999 • 4,699 citations

Direct analysis of protein complexes using mass spectrometry

1999 • 2,242 citations

Linking genome and proteome by mass spectrometry: Large-scale identification of yeast proteins from two dimensional gels

1996 • 1,430 citations

Progress with Proteome Projects: Why all Proteins Expressed by a Genome Should be Identified and How To Do It

1996 • 1,252 citations

Proteomics: quantitative and physical mapping of cellular proteins

1999 • 878 citations

From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis

1996 • 837 citations

Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients

1989 • 308 citations

Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma.

1999 • 279 citations

Advances in protein solubilisation for two-dimensional electrophoresis

1999 • 256 citations

Comprehensive Two-Dimensional High-Performance Liquid Chromatography for the Isolation of Overexpressed Proteins and Proteome Mapping

1998 • 247 citations

High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation

2000 • 219 citations

Micropreparative two‐dimensional electrophoresis allowing the separation of samples containing milligram amounts of proteins

1993 • 191 citations

α-fetoprotein monitoring in chinese patients with chronic hepatitis B virus infection: Role in the early detection of hepatocellular carcinoma

1989 • 185 citations

Cirrhosis and the aetiology of hepatocellular carcinoma

1987 • 178 citations

Proteomics meets cell biology: The establishment of subcellular proteomes

2000 • 175 citations

Towards high performance two-dimensional gel electrophoresis using ultrazoom gels

2000 • 160 citations

Proteomics: applications in basic and applied biology

2000 • 155 citations

Identifying the proteome: software tools

2000 • 134 citations

Subproteomics based upon protein cellular location and relative solubilities in conjunction with composite two-dimensional electrophoresis gels

2000 • 133 citations

Functional genomics by mass spectrometry

2000 • 133 citations

Two-dimensional electrophoresis map of the human hepatocellular carcinoma cell line, HCC-M, and identification of the separated proteins by mass spectrometry

2000 • 131 citations

Renal cell carcinoma and normal kidney protein expression

1997 • 125 citations

Two-dimensional database of mouse liver proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

2000 • 108 citations

Bladder squamous cell carcinoma biomarkers derived from proteomics

2000 • 107 citations

Role of alpha‐fetoprotein in the diagnosis and management of hepatocellular carcinoma

1999 • 105 citations

Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins

1996 • 92 citations

Regular review: Tumour markers in malignancies

2000 • 89 citations

Large-Gel 2-D Electrophoresis

2003 • 85 citations

Characterization of gene expression in clinical lung cancer materials by two‐dimensional polyacrylamide gel electrophoresis

1994 • 74 citations

Proteome analysis of mouse brain: Two-dimensional electrophoresis profiles of tissue proteins during the course of aging

2000 • 73 citations

'Hepatoma-specific' alphafetoprotein may permit preclinical diagnosis of malignant change in patients with chronic liver disease

1997 • 53 citations

Primary malignant neoplasms of the liver: detection with helical CT during arterial portography.

1994 • 51 citations

Characterization of Proteins from Human Cerebrospinal Fluid by a Combination of Preparative Two-Dimensional Liquid-Phase Electrophoresis and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

1998 • 48 citations

Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor α or the peroxisome proliferator nafenopin

2000 • 47 citations

On-line coupling of high performance gel filtration chromatography with imaged capillary isoelectric focusing using a membrane interface

2000 • 44 citations

Proteome analysis of glycoforms: A review of strategies for the microcharacterisation of glycoproteins separated by two‐dimensional polyacrylamide gel electrophoresis

1997 • 42 citations

Mass spectrometric characterization of stathmin isoforms separated by 2D PAGE

1999 • 42 citations

Probability of hepatocellular carcinoma of small hepatocellular nodules undetectable by computed tomography during arterial portography

2000 • 32 citations

Characterization and Use of an Antibody Detecting the CBFβ-SMMHC Fusion Protein in inv(16)/t(16;16)-Associated Acute Myeloid Leukemias

1998 • 24 citations

Tracking pathology with proteomics: Identification ofin vivo degradation products of αB-crystallin

2000 • 21 citations

Serum Copper and Ceruloplasmin in Early and in Advanced Hepatocellular Carcinoma: Diagnostic and Prognostic Relevance

1989 • 17 citations

[A clinical study of complements as a marker of a hepatocellular carcinoma].

1990 • 4 citations

Primary Mediastinal Malignant Germ Cell Tumour Single Institution Experience in Chinese Patients and correlation with specific alpha-fetoprotein bands

1996 • 4 citations