Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

2011 • 16,302 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

2011 • 5,243 citations

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

2007 • 4,193 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Glutamate receptor ion channels

2005 • 3,667 citations

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

2009 • 2,442 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Endoplasmic reticulum stress: cell life and death decisions

2005 • 2,197 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

Memantine in Moderate-to-Severe Alzheimer's Disease

2003 • 1,889 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

2005 • 1,779 citations

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

2008 • 1,728 citations

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

2010 • 1,725 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

2007 • 1,593 citations

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

2007 • 1,501 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?

2007 • 1,455 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells.

2006 • 1,287 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

2006 • 1,206 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

2003 • 1,140 citations

Oxidative stress and Alzheimer disease

2000 • 1,127 citations

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

2009 • 1,083 citations

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

2006 • 1,035 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Oxidative protein folding in eukaryotes

2004 • 990 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

2002 • 965 citations

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

2008 • 875 citations

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

2011 • 871 citations

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

2006 • 868 citations

S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

2006 • 862 citations

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

2007 • 824 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Role of Distinct NMDA Receptor Subtypes at Central Synapses

2004 • 766 citations

NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death BothIn VitroandIn Vivo

2007 • 733 citations

Endoplasmic Reticulum Stress in Disease Pathogenesis

2008 • 718 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2005 • 703 citations

PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

2004 • 691 citations

Expression of Nrf2 in Neurodegenerative Diseases

2007 • 683 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

2006 • 660 citations

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

2010 • 657 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

2008 • 635 citations

The Yin and Yang of NMDA receptor signalling

2003 • 627 citations

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 • 624 citations

Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease

2001 • 610 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

2002 • 563 citations

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

2009 • 550 citations

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

2007 • 548 citations

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

2010 • 542 citations

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

2009 • 542 citations

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease

2003 • 539 citations

Evidence of increased oxidative damage in subjects with mild cognitive impairment

2005 • 533 citations

Proteomic identification of nitrated proteins in Alzheimer's disease brain

2003 • 533 citations

Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

2011 • 526 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

The unfolded protein response is activated in Alzheimer’s disease

2005 • 524 citations

PACS-2 controls endoplasmic reticulum–mitochondria communication and Bid-mediated apoptosis

2005 • 524 citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1999 • 521 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

2003 • 508 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

1998 • 497 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Vitamin E: non-antioxidant roles

2000 • 485 citations

Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

2006 • 484 citations

Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated Apoptosis

2004 • 466 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

2001 • 459 citations

Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease

2002 • 442 citations

Biochemical Basis of Oxidative Protein Folding in the Endoplasmic Reticulum

2000 • 436 citations

A mitochondrial perspective on cell death

2001 • 430 citations

The role of glutathione in disulphide bond formation and endoplasmic‐reticulum‐generated oxidative stress

2006 • 429 citations

Endoplasmic reticulum stress in health and disease

2006 • 420 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

Increased F₂‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidationin vivo

1998 • 411 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

2009 • 402 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

2011 • 388 citations

Mitochondria: The Hub of Cellular Ca²⁺Signaling

2008 • 381 citations

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

2005 • 377 citations

Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2

2003 • 374 citations

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

2009 • 370 citations

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

2006 • 369 citations

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

2009 • 368 citations

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

2009 • 359 citations

Subtype-Specific and ER Lumenal Environment-Dependent Regulation of Inositol 1,4,5-Trisphosphate Receptor Type 1 by ERp44

2005 • 358 citations

A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

2004 • 352 citations

Calcium signaling around Mitochondria Associated Membranes (MAMs)

2011 • 351 citations

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

2011 • 347 citations

Increased 8,12-iso-iPF2?-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity

2000 • 345 citations

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

2010 • 333 citations

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis

2005 • 325 citations

Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: An approach to understand pathological and biochemical alterations in AD

2005 • 322 citations

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores

2002 • 321 citations

Competition between glutathione and protein thiols for disulphide-bond formation

1999 • 309 citations

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal‐regulated kinases (ERK) activity in cultured rat hippocampal neurons

2006 • 304 citations

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

2010 • 301 citations

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

2008 • 297 citations

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

2006 • 296 citations

Brain aging, Alzheimer's disease, and mitochondria

2011 • 296 citations

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?

2002 • 295 citations

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

2009 • 294 citations

SR/ER–mitochondrial local communication: Calcium and ROS

2009 • 290 citations

Induction of neuronal death by ER stress in Alzheimer’s disease

2004 • 284 citations

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

2010 • 284 citations

Synaptic Mitochondria Are More Susceptible to Ca2+Overload than Nonsynaptic Mitochondria

2006 • 283 citations

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

1999 • 283 citations

Amyloid‐Beta Interaction with Mitochondria

2011 • 283 citations

Mitochondria: A therapeutic target in neurodegeneration

2009 • 277 citations

Presenilins are essential for regulating neurotransmitter release

2009 • 276 citations

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

2005 • 273 citations

Cytochrome c oxidase is decreased in Alzheimer’s disease platelets

2003 • 273 citations

Dysregulated IP₃Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca²⁺Signals and Altered Membrane Excitability

2004 • 268 citations

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

2010 • 267 citations

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

2002 • 266 citations

Mitochondrial oxidative stress and cell death in astrocytes —requirement for stored Ca2+ and sustained opening of the permeability transition pore

2002 • 265 citations

Alzheimer's disease-related alterations in synaptic density: Neocortex and hippocampus

2006 • 264 citations

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

2005 • 264 citations

Presenilin 2 modulates endoplasmic reticulum (ER)–mitochondria interactions and Ca ²⁺ cross-talk

2011 • 262 citations

Mitochondria–endoplasmic reticulum choreography: structure and signaling dynamics

2007 • 262 citations

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

2005 • 257 citations

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

2004 • 256 citations

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

2011 • 255 citations

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

1998 • 254 citations

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

2006 • 253 citations

Glutathione Metabolism during Aging and in Alzheimer Disease

2004 • 250 citations

Increased CSF F ₂ -isoprostane concentration in probable AD

1999 • 250 citations

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

2009 • 247 citations

Hepatitis C virus, ER stress, and oxidative stress

2005 • 245 citations

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

2008 • 245 citations

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca ²⁺ release and apoptosis

2008 • 244 citations

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

2008 • 244 citations

Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

2001 • 242 citations

Cerebrospinal fluid F₂‐isoprostane levels are increased in Alzheimer's disease

1998 • 241 citations

Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

2006 • 239 citations

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

1999 • 238 citations

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

2011 • 236 citations

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

2006 • 235 citations

Bcl-2 family on guard at the ER

2009 • 235 citations

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

2008 • 232 citations

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress—elucidation by GADD34‐deficient mice

2003 • 230 citations

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

2008 • 228 citations

Endoplasmic Reticulum Stress Features Are Prominent in Alzheimer Disease but Not in Prion Diseases In Vivo

2006 • 227 citations

A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

2009 • 224 citations

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

2011 • 223 citations

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

2008 • 223 citations

Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease

2002 • 223 citations

Nitrosative Stress, Cellular Stress Response, and Thiol Homeostasis in Patients with Alzheimer's Disease

2006 • 221 citations

Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: Implications for the role of nitration in the progression of Alzheimer's disease

2007 • 219 citations

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

2009 • 219 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Alzheimer Disease

1998 • 211 citations

Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

2011 • 210 citations

MRI and CSF studies in the early diagnosis of Alzheimer's disease

2004 • 209 citations

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

2008 • 207 citations

Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients

2001 • 204 citations

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

2011 • 204 citations

The machinery of local Ca²⁺ signalling between sarco‐endoplasmic reticulum and mitochondria

2000 • 200 citations

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

2006 • 200 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

2009 • 199 citations

Developmental Changes in NMDA Neurotoxicity Reflect Developmental Changes in Subunit Composition of NMDA Receptors

2006 • 196 citations

Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment

2007 • 188 citations

Alzheimer’s and Parkinson’s disease

1991 • 186 citations

The Identification and Characterization of Oxidized RNAs in Alzheimer's Disease

2003 • 182 citations

Brain Regional Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s Disease

2001 • 180 citations

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

2009 • 180 citations

Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias

2007 • 179 citations

Protein oxidation and age-dependent alterations in calcium homeostasis

2000 • 179 citations

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production

2010 • 177 citations

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

2010 • 172 citations

Multiple Defects in Energy Metabolism in Alzheimers Disease

2010 • 172 citations

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

2011 • 170 citations

Aging‐related increase in oxidative stress correlates with developmental pattern of beta‐secretase activity and beta‐amyloid plaque formation in transgenic Tg2576 mice with Alzheimer‐like pathology

2004 • 169 citations

Oxidative damage to DNA in lymphocytes from AD patients

1998 • 169 citations

Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

1999 • 166 citations

DNA strand breaks in Alzheimer's disease

1999 • 166 citations

The Dichotomy of NMDA Receptor Signaling

2007 • 163 citations

Enhanced caffeine‐induced Ca²⁺release in the 3xTg‐AD mouse model of Alzheimer's disease

2005 • 161 citations

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

2010 • 160 citations

Ero1α requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)

2010 • 159 citations

Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

2008 • 152 citations

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

2008 • 152 citations

Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients

2002 • 151 citations

Peripheral F₂‐isoprostanes and F₄‐neuroprostanes are not increased in Alzheimer's disease

2002 • 151 citations

Involvement of endoplasmic reticulum Ca²⁺ release through ryanodine and inositol 1,4,5‐triphosphate receptors in the neurotoxic effects induced by the amyloid‐β peptide

2004 • 149 citations

Ratio of 8-Hydroxyguanine in Intact DNA to Free 8-Hydroxyguanine Is Increased in Alzheimer Disease Ventricular Cerebrospinal Fluid

2001 • 148 citations

The key role of mitochondria in Alzheimer's disease

2006 • 145 citations

Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia

1998 • 141 citations

Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI

2007 • 140 citations

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

2008 • 140 citations

Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease

2002 • 137 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

Calcium dysregulation in Alzheimer's disease: Recent advances gained from genetically modified animals

2005 • 136 citations

Cytochrome c oxidase and nitric oxide in action: Molecular mechanisms and pathophysiological implications

2011 • 133 citations

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

2011 • 132 citations

Influence of the Severity of Cognitive Impairment on the Effect of the <i>Ginkgo biloba</i> Extract EGb 761<sup>®</sup> in Alzheimer’s Disease

2002 • 132 citations

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

2011 • 130 citations

Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type—Place of the extracellular glutathione peroxidase

1996 • 127 citations

NADPH-oxidase activation and cognition in Alzheimer disease progression

2011 • 126 citations

The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain

2002 • 125 citations

Remarkable increase in the concentration of 8‐hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease

2002 • 124 citations

Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria

2001 • 123 citations

Cerebrospinal Fluid Aβ42, Tau, and F2-Isoprostane Concentrations in Patients With Alzheimer Disease, Other Dementias, and in Age-Matched Controls

2001 • 120 citations

Quantification of oxidized RNAs in Alzheimer's disease

2005 • 119 citations

Increased Production of β-Amyloid and Vulnerability to Endoplasmic Reticulum Stress by an Aberrant Spliced Form of Presenilin 2

2001 • 119 citations

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

2009 • 118 citations

Oxidative state in platelets and erythrocytes in aging and Alzheimer's disease

2004 • 118 citations

Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment

2008 • 106 citations

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease

2001 • 105 citations

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease

1997 • 105 citations

Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment

2009 • 104 citations

Oxidative Stress in Alzheimer Patients in Different Stages of the Disease

2006 • 104 citations

Ca²⁺Signaling in Mouse Cortical Neurons Studied by Two-Photon Imaging and Photoreleased Inositol Triphosphate

2003 • 102 citations

ER stress modulates cellular metabolism

2011 • 100 citations

Dynamic Retention of Ero1α and Ero1β in the Endoplasmic Reticulum by Interactions with PDI and ERp44

2006 • 99 citations

Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice

2011 • 98 citations

Amyloid-β-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice

2006 • 97 citations

Oxidatively modified RNA in mild cognitive impairment

2007 • 94 citations

The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's disease

1999 • 90 citations

Exacerbation of Copper Toxicity in Primary Neuronal Cultures Depleted of Cellular Glutathione

1999 • 88 citations

Nitric oxide-dependent modification of the sarcoplasmic reticulum Ca-ATPase: localization of cysteine target sites

2000 • 86 citations

Oxidative Damage and Progression to Alzheimer's Disease in Patients with Mild Cognitive Impairment

2010 • 82 citations

Enhanced brain levels of 8,12- iso -iPF _2α -VI differentiate AD from frontotemporal dementia

2003 • 82 citations

E2-25K/Hip-2 regulates caspase-12 in ER stress–mediated Aβ neurotoxicity

2008 • 82 citations

Longitudinal CSF isoprostane and MRI atrophy in the progression to AD

2007 • 82 citations

Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

2010 • 81 citations

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

2009 • 79 citations

High-Capacity Redox Control at the Plasma Membrane of Mammalian Cells: Trans-Membrane, Cell Surface, and Serum NADH-Oxidases

2000 • 79 citations

Apoptosis And Calcium: New Roles For Cytochrome c and Inositol 1,4,5-trisphosphate

2004 • 78 citations

Silencing GADD153/CHOP Gene Expression Protects against Alzheimer's Disease-Like Pathology Induced by 27-Hydroxycholesterol in Rabbit Hippocampus

2011 • 77 citations

Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease

2004 • 76 citations

Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

2010 • 72 citations

Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease

2003 • 72 citations

Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease

2004 • 68 citations

Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions

2011 • 67 citations

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

2010 • 66 citations

Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the CSF of patients with Alzheimer’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

2009 • 66 citations

Increased Susceptibility to Plasma Lipid Peroxidation in Alzheimer Disease Patients

2004 • 65 citations

Plasma F2A Isoprostane Levels in Alzheimer’s and Parkinson’s Disease

2007 • 63 citations

Activation of NOX2 by the Stimulation of Ionotropic and Metabotropic Glutamate Receptors Contributes to Glutamate Neurotoxicity In Vivo Through the Production of Reactive Oxygen Species and Calpain Activation

2011 • 63 citations

Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer's disease

2007 • 61 citations

Increased Association Between Rough Endoplasmic Reticulum Membranes and Mitochondria in Transgenic Mice That Express P301L Tau

2009 • 61 citations

ER Stress-Mediated Apoptotic Pathway Induced by Aβ Peptide Requires the Presence of Functional Mitochondria

2010 • 59 citations

Why Vitamin E Therapy Fails for Treatment of Alzheimer's Disease

2010 • 58 citations

Toxicity of β-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-d-aspartate receptor subunits

2007 • 55 citations

Mitochondria Are Related to Synaptic Pathology in Alzheimer′s Disease

2011 • 54 citations

Cortical biochemistry in MCI and Alzheimer disease

2007 • 54 citations

Protein oxidation and age-dependent alterations in calcium homeostasis

2000 • 52 citations

Different Contributions of the Three CXXC Motifs of Human Protein-disulfide Isomerase-related Protein to Isomerase Activity and Oxidative Refolding

2004 • 52 citations

Endoplasmic reticulum stress enhances γ-secretase activity

2011 • 51 citations

Different expression of calreticulin and immunoglobulin binding protein in Alzheimer's disease brain

2000 • 51 citations

Increased urinary F2-isoprostanes levels in the patients with Alzheimer’s disease

2004 • 48 citations

Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor

2006 • 47 citations

Protein Disulfide Isomerase in Alzheimer Disease

2000 • 47 citations

The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation

2009 • 47 citations

8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease

1996 • 45 citations

Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, Turkey

2006 • 45 citations

Long-term Phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing A Beta

2011 • 44 citations

Amyloid precursor protein promotes endoplasmic reticulum stress‐induced cell death via C/EBP homologous protein‐mediated pathway

2009 • 43 citations

The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion

2006 • 42 citations

Effects of Redox Potential and Ca2+ on the Inositol 1,4,5-Trisphosphate Receptor L3-1 Loop Region

2008 • 40 citations

Increased Aβ1-42 Production Sensitizes Neuroblastoma Cells for ER Stress Toxicity

2008 • 40 citations

Bcl-2 Overexpression Protects Against Amyloid-Beta and Prion Toxicity in GT1-7 Neural Cells

2007 • 39 citations

Oxidation of Kinetically Trapped Thiols by Protein Disulfide Isomerase

1995 • 37 citations

Caspase-12 Activation is Involved in Amyloid-β Protein-Induced Synaptic Toxicity

2011 • 31 citations

The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders

2011 • 24 citations

A Persistent Stress Response to Impeded Axonal Transport Leads to Accumulation of Amyloid-β in the Endoplasmic Reticulum, and Is a Probable Cause of Sporadic Alzheimer’s Disease

2011 • 23 citations

Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E

2007 • 23 citations

Role of WWOX WOX1 in Alzheimer s disease pathology and in cell death signaling

2012 • 21 citations

Cytochrome c: A Crosslink between the Mitochondria and the Endoplasmic Reticulum in Calcium-Dependent Apoptosis

2004 • 20 citations

Role of WWOX WOX1 in Alzheimer s disease pathology and in cell death signaling

2012 • 9 citations

Deleted Work

1955 • 0 citations