Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

2008 • 1,728 citations

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

2007 • 1,353 citations

Obesity, Metabolic Syndrome, and Cardiovascular Disease

2004 • 1,318 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

The endoplasmic reticulum and the unfolded protein response

2007 • 936 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

2003 • 851 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

2008 • 653 citations

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 • 624 citations

Mitochondrial calcium signalling and cell death: Approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis

2006 • 588 citations

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

2007 • 548 citations

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

2009 • 402 citations

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

2008 • 391 citations

Subtype-Specific and ER Lumenal Environment-Dependent Regulation of Inositol 1,4,5-Trisphosphate Receptor Type 1 by ERp44

2005 • 358 citations

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

2005 • 339 citations

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

2009 • 320 citations

Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids

2004 • 272 citations

Characterization of responses of isolated rat hepatocytes to ATP and ADP.

1985 • 269 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions

2006 • 262 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

Ca2+-dependent redox modulation of SERCA 2b by ERp57

2003 • 228 citations

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

2008 • 226 citations

Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway

2001 • 199 citations

Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway

2000 • 183 citations

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages

2006 • 169 citations

Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

2008 • 134 citations

The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response

2003 • 101 citations

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress

2008 • 78 citations

CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation

2006 • 42 citations

Effects of Redox Potential and Ca2+ on the Inositol 1,4,5-Trisphosphate Receptor L3-1 Loop Region

2008 • 40 citations

Inositol-1,4,5-Trisphosphate Receptor-Mediated Ca Mobilization Is Not Required for Cerebellar Long-Term Depression in Reduced Preparations

1998 • 37 citations