Endoplasmic reticulum stress in health and disease

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Endoplasmic reticulum stress: cell life and death decisions

2005 • 2,197 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

ER stress and the unfolded protein response

2004 • 1,696 citations

Folding proteins in fatal ways

2003 • 1,394 citations

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

2005 • 1,345 citations

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

2004 • 1,334 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

From acute ER stress to physiological roles of the Unfolded Protein Response

2006 • 850 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

ER stress and neurodegenerative diseases

2006 • 822 citations

Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

2006 • 788 citations

The role of the unfolded protein response in tumour development: friend or foe?

2004 • 685 citations

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

2005 • 674 citations

Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

2006 • 642 citations

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1996 • 634 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth

2004 • 537 citations

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

2005 • 529 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

Endoplasmic Reticulum Stress-induced Apoptosis

2006 • 490 citations

Endoplasmic Reticulum Stress and the Development of Diabetes

2002 • 455 citations

A transgenic mouse model for monitoring endoplasmic reticulum stress

2003 • 452 citations

Stress-induced gene expression requires programmed recovery from translational repression

2003 • 450 citations

PERK mediates cell-cycle exit during the mammalian unfolded protein response

2000 • 447 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

2004 • 406 citations

Viruses, endoplasmic reticulum stress, and interferon responses

2006 • 400 citations

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

2005 • 399 citations

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease

2004 • 391 citations

eIF2 and the control of cell physiology

2004 • 372 citations

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 ^IPK

2002 • 360 citations

The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control

2000 • 338 citations

The ASK1-MAP Kinase Cascades in Mammalian Stress Response

2004 • 331 citations

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

2006 • 306 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

2005 • 286 citations

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

1999 • 281 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

2003 • 272 citations

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

1999 • 270 citations

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

2004 • 246 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy

2005 • 238 citations

ER Stress, Hypoxia Tolerance and Tumor Progression

2006 • 229 citations

GM1-Ganglioside-Mediated Activation of the Unfolded Protein Response Causes Neuronal Death in a Neurodegenerative Gangliosidosis

2004 • 228 citations

The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone

2005 • 225 citations

Cerebral ischemia and the unfolded protein response

2004 • 224 citations

Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

2005 • 207 citations

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

2005 • 204 citations

Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation

2005 • 185 citations

Endoplasmic Reticulum Stress and Unfolded Protein Response in Inclusion Body Myositis Muscle

2004 • 182 citations

Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response

2004 • 174 citations

Activation of Endoplasmic Reticulum-Specific Stress Responses Associated with the Conformational Disease Z α1-Antitrypsin Deficiency

2004 • 174 citations

Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis

2005 • 172 citations

Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol

2004 • 167 citations

Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation

2005 • 164 citations

Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres

1998 • 162 citations

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

2002 • 151 citations

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression

2000 • 135 citations

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

2002 • 130 citations

Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia

2004 • 123 citations

Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent Mechanism

2005 • 122 citations

Building an antibody factory: a job for the unfolded protein response

2004 • 109 citations

Retention of Mutant Low Density Lipoprotein Receptor in Endoplasmic Reticulum (ER) Leads to ER Stress

2005 • 87 citations

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway

2005 • 67 citations

Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL

2006 • 61 citations

The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase

2004 • 43 citations

Involvement of Endoplasmic Reticulum Stress in Hereditary Tyrosinemia Type I

2005 • 33 citations