Endoplasmic reticulum stress: cell life and death decisions

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

The biochemistry of apoptosis

2000 • 7,314 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Mitochondrial control of cell death

2000 • 3,098 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

Regulation of cell death: the calcium–apoptosis link

2003 • 2,826 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

ER stress and the unfolded protein response

2004 • 1,696 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

2005 • 1,345 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Regulation of apoptosis by endoplasmic reticulum pathways

2003 • 718 citations

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

1997 • 655 citations

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 • 624 citations

Bcl-2-mediated alterations in endoplasmic reticulum Ca ²⁺ analyzed with an improved genetically encoded fluorescent sensor

2004 • 613 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1999 • 521 citations

Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast

1998 • 514 citations

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

2003 • 512 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated Apoptosis

2004 • 466 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

The calpain family and human disease

2001 • 465 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

2004 • 427 citations

Caspase and calpain substrates: Roles in synaptic plasticity and cell death

1999 • 423 citations

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

2004 • 416 citations

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

2004 • 416 citations

ER chaperone functions during normal and stress conditions

2004 • 414 citations

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

2004 • 406 citations

Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

2004 • 402 citations

Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion

2001 • 392 citations

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1997 • 384 citations

Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells

1997 • 370 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

Human caspase 12 has acquired deleterious mutations

2002 • 348 citations

The ASK1-MAP Kinase Cascades in Mammalian Stress Response

2004 • 331 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum

1997 • 322 citations

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

2002 • 311 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

Flirting in Little Space: The ER/Mitochondria Ca ²⁺ Liaison

2004 • 303 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

1995 • 296 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress

2004 • 292 citations

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

2000 • 285 citations

The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum

2004 • 282 citations

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

1999 • 281 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

Apoptosis of T Cells Mediated by Ca ²⁺ -Induced Release of the Transcription Factor MEF2

1999 • 262 citations

Cardiolipin and apoptosis

2002 • 260 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Up-regulation of Protein-disulfide Isomerase in Response to Hypoxia/Brain Ischemia and Its Protective Effect against Apoptotic Cell Death

2000 • 258 citations

Stabilization and Enhancement of the Antiapoptotic Activity of Mcl-1 by TCTP

2005 • 225 citations

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

2003 • 223 citations

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK

2001 • 214 citations

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

2003 • 212 citations

Caspase-dependent Activation of Calpain during Drug-induced Apoptosis

1999 • 206 citations

Caspases involved in ER stress-mediated cell death

2004 • 204 citations

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB

2004 • 202 citations

Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter

2000 • 195 citations

Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast

2003 • 195 citations

BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins

2000 • 185 citations

Modulation of endoplasmic reticulum calcium pump by Bcl-2

1998 • 184 citations

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

2002 • 180 citations

Protein precipitation: a common etiology in neurodegenerative disorders?

1998 • 158 citations

Endoplasmic Reticulum Stress and Diabetes Mellitus.

2003 • 149 citations

Targeting of the c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced Apoptosis

2001 • 129 citations

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

2002 • 123 citations

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

2002 • 120 citations

Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome cfrom Mitochondria

2000 • 117 citations

Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction

1998 • 117 citations

Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region

2004 • 112 citations

Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance

2003 • 108 citations

Inactivation of Caspase-8 on Mitochondria of Bcl-xL-expressing MCF7-Fas Cells

2002 • 107 citations

Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death

2000 • 98 citations

Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1

2002 • 90 citations

Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil

1997 • 80 citations

Spike, a novel BH3‐only protein, regulates apoptosis at the endoplasmic reticulum

2003 • 77 citations

The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

2002 • 74 citations

Neurons overexpressing mutant presenilin‐1 are more sensitive to apoptosis induced by endoplasmic reticulum‐Golgi stress

2002 • 72 citations

Uncleaved BAP31 in Association with A4 Protein at the Endoplasmic Reticulum Is an Inhibitor of Fas-initiated Release of Cytochromec from Mitochondria

2003 • 71 citations

Ryanodine receptor channelopathies

2004 • 66 citations

Involvement of Gadd153 in the pathogenic action of presenilin‐1 mutations

2002 • 66 citations

Parkin and Endoplasmic Reticulum Stress

2003 • 55 citations

Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways

2003 • 53 citations

Expression of bak in S. pombe results in a lethality mediated through interaction with the calnexin homologue Cnx1

1997 • 37 citations

Type 3 inositol 1,4,5‐trisphosphate receptor modulates cell death

2000 • 34 citations

The calcium connection

1997 • 20 citations