Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the CSF of patients with Alzheimer’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process
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References (39)
“Mini-mental state”
1975 • 82,784 citations
Clinical diagnosis of Alzheimer's disease
1984 • 27,279 citations
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
2003 • 8,902 citations
A New Clinical Scale for the Staging of Dementia
1982 • 6,699 citations
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
1991 • 4,533 citations
Cerebral Blood Flow in Dementia
1975 • 3,133 citations
Alzheimer's disease
2006 • 2,827 citations
Premature ageing in mice expressing defective mitochondrial DNA polymerase
2004 • 2,561 citations
Oxidative Damage Is the Earliest Event in Alzheimer Disease
2001 • 1,833 citations
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
1988 • 1,709 citations
Mitochondrial Abnormalities in Alzheimer's Disease
2001 • 1,319 citations
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
2004 • 1,232 citations
4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease
1997 • 1,018 citations
Effects of Coenzyme Q10 in Early Parkinson Disease
2002 • 965 citations
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
1989 • 733 citations
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
1999 • 718 citations
Fish, meat, and risk of dementia: cohort study
2002 • 482 citations
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
2009 • 359 citations
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide
2001 • 340 citations
Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
1997 • 321 citations
Simultaneous Detection of Ubiquinol and Ubiquinone in Human Plasma as a Marker of Oxidative Stress
1997 • 216 citations
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
2000 • 175 citations
Oxidative stress: a role in the pathogenesis of Parkinson’s disease
1990 • 144 citations
RNA oxidation in Alzheimer disease and related neurodegenerative disorders
2009 • 140 citations
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: On defects in the cytochrome c oxidase complex and aldehyde detoxification
2006 • 118 citations
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain
2008 • 106 citations
Carbonylated proteins in aging and exercise: immunoblot approaches
1999 • 104 citations
Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease
2008 • 104 citations
Evaluation of Coenzyme Q as an Antioxidant Strategy for Alzheimer's Disease
2008 • 95 citations
Oxidative damage in the olfactory system in Alzheimer's disease
2003 • 77 citations
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease
2001 • 63 citations
High-performance liquid chromatography of coenzyme Q-related compounds and its application to biological materials
1985 • 61 citations
Serum levels of coenzyme Q10 in patients with Parkinson's disease
2000 • 52 citations
Serum levels of coenzyme Q 10 in patients with Alzheimer's disease
2000 • 39 citations
FORMATION OF LIPID HYDROPEROXIDES IN THE CUPRIC ION-INDUCED OXIDATION OF PLASMA AND LOW DENSITY LIPOPROTEIN
1991 • 29 citations
3-Hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain
2001 • 22 citations
Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde
2007 • 20 citations
Coenzyme Q, Vitamin E and Apo‐E alleles in Alzheimer Disease
2003 • 17 citations
Muscle biopsy in Alzheimer's disease: morphological and biochemical findings.
1991 • 9 citations