An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

The versatility and universality of calcium signalling

2000 • 5,407 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

2003 • 1,027 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1983 • 844 citations

A Dissection and tissue culture manual of the nervous system

1989 • 762 citations

Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease

2002 • 566 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

2003 • 547 citations

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

1996 • 506 citations

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1997 • 488 citations

Endoplasmic reticulum of animal cells and its organization into structural and functional domains

2001 • 442 citations

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

2003 • 390 citations

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

1997 • 386 citations

Oxidative stress signalling in Alzheimer's disease

2004 • 384 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

1999 • 381 citations

Evidence of Presynaptic Location and Function of the Prion Protein

1999 • 350 citations

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

1996 • 321 citations

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

2000 • 304 citations

Induction of neuronal death by ER stress in Alzheimer’s disease

2004 • 284 citations

Molecular biology and pathogenesis of prion diseases

1996 • 279 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease

1997 • 253 citations

Hepatitis C virus, ER stress, and oxidative stress

2005 • 245 citations

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12

2004 • 244 citations

Cellular prion protein localization in rodent and primate brain

1998 • 222 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity

2005 • 198 citations

Biology of Aβ Amyloid in Alzheimer's Disease

1997 • 187 citations

Damage to the Endoplasmic Reticulum and Activation of Apoptotic Machinery by Oxidative Stress in Ischemic Neurons

2005 • 170 citations

The mouse MPTP model: gene expression changes in dopaminergic neurons

2003 • 165 citations

The Oxidative Inactivation of Sarcoplasmic Reticulum Ca²⁺-ATPase by Peroxynitrite

1996 • 162 citations

Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

1999 • 161 citations

Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states

2001 • 152 citations

Prion Protein Fragment PrP-(106–126) Induces Apoptosis via Mitochondrial Disruption in Human Neuronal SH-SY5Y Cells

2001 • 150 citations

Involvement of endoplasmic reticulum Ca²⁺ release through ryanodine and inositol 1,4,5‐triphosphate receptors in the neurotoxic effects induced by the amyloid‐β peptide

2004 • 149 citations

The unfolded protein response and Alzheimer’s disease

2001 • 145 citations

Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation

1983 • 135 citations

In Vivo Cytotoxicity of the Prion Protein Fragment 106–126

2000 • 132 citations

Signal transduction during amyloid-β-peptide neurotoxicity: role in Alzheimer disease

2004 • 128 citations

Induction of cytochrome c-mediated apoptosis by amyloid β 25-35 requires functional mitochondria

2002 • 102 citations

Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3

2003 • 102 citations

Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine Receptor

2000 • 100 citations

PrPSc-like prion protein peptide inhibits the function of cellular prion protein

2000 • 97 citations

Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway

2002 • 95 citations

Involvement of calcineurin in the neurotoxic effects induced by amyloid‐beta and prion peptides

2003 • 89 citations

Neurotrophin p75 Receptor Is Involved in Neuronal Damage by Prion Peptide-(106–126)

2001 • 84 citations

Dendritic and synaptic alterations of hippocampal pyramidal neurones in scrapie‐infected mice

2000 • 78 citations

Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer’s disease 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is a part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 66 citations

Effects of Hypoxanthine–Xanthine Oxidase on Ca ²⁺ Stores and Protein Synthesis in Human Endothelial Cells

1995 • 63 citations

Caspases‐2, ‐3, and ‐7 are involved in thapsigargin‐induced apoptosis of SH‐SY5Y neuroblastoma cells

2005 • 62 citations

Prion peptide 106-126 as a model for prion replication and neurotoxicity

2002 • 45 citations

Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts

2002 • 43 citations

Rabbit brain endoplasmic reticulum membranes as target for free radicals. Changes in Ca(2+)-transport and protection by stobadine.

1995 • 39 citations

Prion peptide 106-126 as a model for prion replication and neurotoxicity

2002 • 34 citations

Increased iron-induced oxidative stress and toxicity in scrapie-infected neuroblastoma cells

2005 • 33 citations

PrPSc-like prion protein peptide inhibits the function of cellular prion protein

2000 • 29 citations

Influence of isolation media on synaptosomal properties: Intracellular pH, pCa, and Ca2+ uptake

1990 • 26 citations

α-KETO-ß-METHYL-n-VALERIC ACID DIMINISHES REACTIVE OXYGEN SPECIES AND ALTERS ENDOPLASMIC RETICULUM Ca2+ STORES

2004 • 25 citations

Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?

2003 • 12 citations