Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

2002 • 965 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

2004 • 742 citations

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

2000 • 511 citations

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

2000 • 480 citations

Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1

2003 • 468 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

Nicastrin Functions as a γ-Secretase-Substrate Receptor

2005 • 444 citations

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

2004 • 416 citations

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

1994 • 319 citations

Enhanced Ryanodine Receptor Recruitment Contributes to Ca²⁺Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

2006 • 316 citations

Presenilin-Mediated Modulation of Capacitative Calcium Entry

2000 • 311 citations

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

1999 • 310 citations

Dysregulated IP₃Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca²⁺Signals and Altered Membrane Excitability

2004 • 268 citations

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

2002 • 265 citations

A Nine-transmembrane Domain Topology for Presenilin 1

2005 • 194 citations

Introduction and Overview

1989 • 189 citations

Calcium leak from intracellular stores—the enigma of calcium signalling

2002 • 187 citations

Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

2005 • 179 citations

Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus

1999 • 161 citations

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin‐1 Mutant Mice

1999 • 157 citations

Calcium dysregulation in Alzheimer's disease: Recent advances gained from genetically modified animals

2005 • 136 citations

Presenilin-2 Mutations Modulate Amplitude and Kinetics of Inositol 1,4,5-Trisphosphate-mediated Calcium Signals

1999 • 133 citations

Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores

2004 • 132 citations

Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation

2001 • 131 citations

Functional Characterization of Mammalian Inositol 1,4,5-Trisphosphate Receptor Isoforms

2004 • 124 citations

Nystatin-induced liposome fusion. A versatile approach to ion channel reconstitution into planar bilayers

1990 • 122 citations

Basal and Physiological Ca2+ Leak from the Endoplasmic Reticulum of Pancreatic Acinar Cells

2002 • 120 citations

Capacitive Calcium Entry Is Directly Attenuated by Mutant Presenilin-1, Independent of the Expression of the Amyloid Precursor Protein

2003 • 112 citations

Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin

2003 • 108 citations

Modulation of Mammalian Inositol 1,4,5-Trisphosphate Receptor Isoforms by Calcium: A Role of Calcium Sensor Region

2004 • 100 citations

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

2006 • 87 citations

Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

2001 • 56 citations

The presenilins.

2002 • 53 citations

The Presenilin 1 ΔE9 Mutation Gives Enhanced Basal Phospholipase C Activity and a Resultant Increase in Intracellular Calcium Concentrations

2002 • 53 citations

Presenilin 2 regulates the systolic function of heart by modulating Ca²⁺signaling

2005 • 48 citations

Capacitative Calcium Entry Induces Hippocampal Long Term Potentiation in the Absence of Presenilin-1

2003 • 32 citations

Measurement of Free [Ca<sup>2+</sup>] Changes in Agonist-Sensitive Internal Stores Using Compartmentalized Fluorescent Indicators

2003 • 19 citations