The ER stress factor XBP1s prevents amyloid-β neurotoxicity

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Signal integration in the endoplasmic reticulum unfolded protein response

2007 • 5,948 citations

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

2007 • 4,449 citations

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

2005 • 1,189 citations

ER stress and diseases

2007 • 1,043 citations

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

2003 • 928 citations

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

2008 • 853 citations

XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks

2007 • 795 citations

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

2009 • 793 citations

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

2007 • 719 citations

Endoplasmic Reticulum Stress in Disease Pathogenesis

2008 • 718 citations

Molecular mechanisms of neurodegeneration in Alzheimer's disease

2010 • 674 citations

Identification of genes that modify ataxin-1-induced neurodegeneration

2000 • 659 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

The unfolded protein response is activated in Alzheimer’s disease

2005 • 524 citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1999 • 521 citations

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

2009 • 497 citations

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1999 • 483 citations

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

2003 • 390 citations

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

2009 • 389 citations

Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons

2003 • 366 citations

Enhanced Ryanodine Receptor Recruitment Contributes to Ca²⁺Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

2006 • 316 citations

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons

2000 • 310 citations

Linking Calcium to Aβ and Alzheimer's Disease

2008 • 307 citations

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

2006 • 306 citations

Cell-to-cell transmission of non-prion protein aggregates

2010 • 288 citations

Induction of the Unfolded Protein Response in Familial Amyotrophic Lateral Sclerosis and Association of Protein-disulfide Isomerase with Superoxide Dismutase 1

2006 • 278 citations

Unfolded protein response in a Drosophila model for retinal degeneration

2006 • 273 citations

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease

2002 • 272 citations

Dysregulated IP₃Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca²⁺Signals and Altered Membrane Excitability

2004 • 268 citations

Endoplasmic Reticulum Stress Features Are Prominent in Alzheimer Disease but Not in Prion Diseases In Vivo

2006 • 227 citations

Introduction and Overview

1989 • 189 citations

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

2010 • 172 citations

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation

2010 • 168 citations

Enhanced caffeine‐induced Ca²⁺release in the 3xTg‐AD mouse model of Alzheimer's disease

2005 • 161 citations

Involvement of endoplasmic reticulum Ca²⁺ release through ryanodine and inositol 1,4,5‐triphosphate receptors in the neurotoxic effects induced by the amyloid‐β peptide

2004 • 149 citations

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

2008 • 143 citations

Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies

1999 • 142 citations

Protective effect against Parkinson's disease-related insults through the activation of XBP1

2008 • 139 citations

Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice

2003 • 128 citations

Amyloid-β-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice

2006 • 97 citations

The ryanodine receptor is essential for larval development in Drosophila melanogaster

2000 • 94 citations

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation

2009 • 89 citations

Calcium, membranes, aging, and Alzheimer's disease

1989 • 77 citations

XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

2006 • 73 citations

Perturbation of Endoplasmic Reticulum Homeostasis Facilitates Prion Replication

2007 • 66 citations

Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle

2007 • 59 citations

PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

2006 • 57 citations

Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta‐amyloid peptide toxicity

2003 • 56 citations

The xbp-1 gene is essential for development in Drosophila

2007 • 46 citations

Identifying genes that interact with Drosophila presenilin and amyloid precursor protein

2009 • 37 citations

Possible Involvement of ER Chaperone Grp78 on Reduced Formation of Amyloid‐β Deposits

2002 • 21 citations