Cytochrome c oxidase and nitric oxide in action: Molecular mechanisms and pathophysiological implications

On Respiratory Impairment in Cancer Cells

1956 • 2,963 citations

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

2008 • 2,433 citations

The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å

1996 • 2,089 citations

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

1995 • 1,991 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Oxygen activation and the conservation of energy in cell respiration

1992 • 1,121 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Structure at 2.7 Å resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody F _V fragment

1997 • 678 citations

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

2008 • 663 citations

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

2001 • 596 citations

The X-ray Crystal Structures of Wild-type and EQ(I-286) Mutant Cytochrome c Oxidases from Rhodobacter sphaeroides

2002 • 544 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

2007 • 530 citations

Proton-Coupled Electron Transfer in Cytochrome Oxidase

2010 • 490 citations

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: Implications for oxygen sensing and hypoxic signaling in eukaryotes

2006 • 472 citations

Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus

2000 • 464 citations

The cytochrome bd respiratory oxygen reductases

2011 • 462 citations

Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

2000 • 445 citations

A novel scenario for the evolution of haem–copper oxygen reductases

2001 • 442 citations

Autoxidation kinetics of aqueous nitric oxide

1993 • 412 citations

The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process

2003 • 411 citations

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

1994 • 407 citations

Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection

2001 • 406 citations

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

2008 • 396 citations

The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site.

2000 • 386 citations

Reactions of cytochrome oxidase with oxygen and carbon monoxide

1963 • 382 citations

Functional intermediates in the reaction of membrane-bound cytochrome oxidase with oxygen.

1975 • 366 citations

Non-enzymatic nitric oxide synthesis in biological systems

1999 • 361 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Kinetic and Mechanistic Studies of the NO^•-Mediated Oxidation of Oxymyoglobin and Oxyhemoglobin

2001 • 323 citations

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

1999 • 300 citations

Nonenzymatic Nitric Oxide Production in Humans

1998 • 295 citations

Nitrite Reductase Function of Deoxymyoglobin

2007 • 280 citations

Nitric Oxide

1995 • 266 citations

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

1996 • 243 citations

Cytochrome oxidase evolved by tinkering with denitrification enzymes

1994 • 241 citations

The Structure of cbb ₃ Cytochrome Oxidase Provides Insights into Proton Pumping

2010 • 238 citations

Cytochrome bd terminal oxidase1All amino acid numbering refers to the E. coli enzyme.1

1997 • 237 citations

Role of Endothelium-Derived Nitric Oxide in the Modulation of Canine Myocardial Mitochondrial Respiration In Vitro

1996 • 233 citations

Reactions of nitric oxide with cytochrome c oxidase

1980 • 232 citations

Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase

2006 • 222 citations

Cytochrome c Oxidase and the Regulation of Oxidative Phosphorylation

2001 • 216 citations

Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?

2002 • 215 citations

Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase

2001 • 211 citations

The heme-copper oxidase family consists of three distinct types of terminal oxidases and is related to nitric oxide reductase

1994 • 207 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Oxygen "pulsed" cytochrome c oxidase: functional properties and catalytic relevance.

1977 • 191 citations

The catalytic cycle of cytochrome c oxidase is not the sum of its two halves

2003 • 191 citations

Reaction of Oxygen with the Respiratory Chain in Cells and Tissues

1965 • 190 citations

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase

2004 • 182 citations

Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs.

1995 • 176 citations

Elevated Oxidative Stress in Patients with Ataxia Telangiectasia

2002 • 168 citations

Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology

2007 • 168 citations

Nitric Oxide and Cytochrome c Oxidase: Mechanisms of Inhibition and NO Degradation

2000 • 161 citations

Cytochrome bd confers nitric oxide resistance to Escherichia coli

2008 • 157 citations

Oxygen-Dependent Regulation of Mitochondrial Energy Metabolism by Nitric Oxide

1995 • 156 citations

Proton Pumping Mechanism in Cytochrome c Oxidase

2008 • 155 citations

High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: New insights into the active site and the proton transfer pathways

2009 • 154 citations

The heme-copper oxidases of Thermus thermophilus catalyze the reduction of nitric oxide: Evolutionary implications

1999 • 152 citations

Proton pumping by cytochrome oxidase: progress, problems and postulates

2000 • 150 citations

Bovine cytochrome c oxidase structures enable O ₂ reduction with minimization of reactive oxygens and provide a proton-pumping gate

2010 • 144 citations

On the Mechanism of Inhibition of Cytochrome c Oxidase by Nitric Oxide

1996 • 142 citations

The reaction of the electrostatic cytochrome c-cytochrome oxidase complex with oxygen

1991 • 142 citations

Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex

1998 • 137 citations

A peroxide bridge between Fe and Cu ions in the O ₂ reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump

2009 • 134 citations

Redox-driven proton pumping by heme-copper oxidases

2003 • 133 citations

Effects of Oxygen Concentration on the Expression of Cytochrome c and Cytochrome c Oxidase Genes in Yeast

1997 • 132 citations

The Cytochrome c Oxidase from Paracoccus denitrificans Does Not Change the Metal Center Ligation upon Reduction

1999 • 129 citations

Studies of the primary oxygen intermediate in the reaction of fully reduced cytochrome oxidase.

1991 • 122 citations

Cytochrome oxidase, ligands and electrons

2004 • 121 citations

Permeability of Nitric Oxide through Lipid Bilayer Membranes

1996 • 120 citations

Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology

2006 • 119 citations

The cytochrome cbb₃ from Pseudomonas stutzeri displays nitric oxide reductase activity

2001 • 118 citations

The reaction of cytochrome oxidase with cyanide. Preparation of the rapidly reacting form and its conversion to the slowly reacting form.

1987 • 117 citations

Characterisation of ‘fast’ and ‘slow’ forms of bovine heart cytochrome-c oxidase

1991 • 115 citations

Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling

2008 • 115 citations

Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.

1979 • 112 citations

Modeling the sequence of electron transfer reactions in the single turnover of reduced, mammalian cytochrome c oxidase with oxygen.

1994 • 107 citations

Cytochrome c oxidase rapidly metabolises nitric oxide to nitrite

2000 • 106 citations

A Common Mechanism for the Interaction of Nitric Oxide with the Oxidized Binuclear Centre and Oxygen Intermediates of Cytochromec Oxidase

1998 • 105 citations

Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?

1997 • 104 citations

Control of cytochrome c oxidase activity by nitric oxide

2003 • 102 citations

Nitric oxide and cytochrome oxidase: reaction mechanisms from the enzyme to the cell

2003 • 101 citations

Mass spectrometric determination of dioxygen bond splitting in the “peroxy” intermediate of cytochrome c oxidase

1999 • 100 citations

Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions

1990 • 99 citations

Crystal structure of bovine heart cytochrome c oxidase at 2.8 A resolution.

1998 • 97 citations

Kinetics of the reactions of nitrogen monoxide and nitrite with ferryl hemoglobin

2003 • 95 citations

The Catabolic Fate of Nitric Oxide

2002 • 94 citations

The invisible copper of cytochrome c oxidase

1975 • 94 citations

Mitochondria and Hypoxic Signaling

2009 • 93 citations

Reaction of hydrogen peroxide with the rapid form of resting cytochrome oxidase

1991 • 93 citations

Reversal of Cyanide Inhibition of Cytochrome c Oxidase by the Auxiliary Substrate Nitric Oxide

2003 • 90 citations

Coupled proton and electron transfer reactions in cytochrome oxidase

2004 • 88 citations

Interaction of the bacterial terminal oxidase cytochrome bd with nitric oxide

2004 • 83 citations

Cytochrome bd oxidase and nitric oxide: From reaction mechanisms to bacterial physiology

2011 • 80 citations

Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation

2007 • 77 citations

Redox control of fast ligand dissociation from Escherichia coli cytochrome bd

2007 • 77 citations

Looking for the minimum common denominator in haem–copper oxygen reductases: Towards a unified catalytic mechanism

2008 • 75 citations

Reaction of Nitric Oxide with the Turnover Intermediates of Cytochrome c Oxidase: Reaction Pathway and Functional Effects

2000 • 73 citations

A discrete water exit pathway in the membrane protein cytochrome c oxidase

2003 • 72 citations

Nitric oxide and the respiratory enzyme

2006 • 72 citations

A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochromeba₃oxidase fromThermus thermophilus

2005 • 69 citations

Cytochrome c Oxidase Does Not Catalyze the Anaerobic Reduction of NO

1998 • 68 citations

Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy

1999 • 65 citations

Electron transfer process in cytochrome oxidase after pulse radiolysis

1989 • 63 citations

FTIR Detection of Protonation/Deprotonation of Key Carboxyl Side Chains Caused by Redox Change of the Cu_A-Heme a Moiety and Ligand Dissociation from the Heme a₃-Cu_B Center of Bovine Heart Cytochrome c Oxidase

2003 • 62 citations

Electron transfer and energy transduction in the terminal part of the respiratory chain — Lessons from bacterial model systems

2009 • 59 citations

On the Biologic Role of the Reaction of NO with Oxidized CytochromecOxidase

2007 • 54 citations

The chemistry of the CuB site in cytochrome c oxidase and the importance of its unique His–Tyr bond

2009 • 53 citations

Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide

2006 • 52 citations

Similarity of cytochrome c oxidases in different organisms

2010 • 51 citations

Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump

2011 • 51 citations

Cytochrome bo3 from Escherichia coli: the binding and turnover of nitric oxide

2002 • 51 citations

Analysis of site-directed mutants locates a non-redox-active metal near the active site of cytochrome c oxidase of Rhodobacter sphaeroides

1995 • 51 citations

Nitric oxide reacts with the ferryl‐oxo catalytic intermediate of the Cu_B‐lacking cytochrome bd terminal oxidase

2006 • 50 citations

Cytochrome c oxidase as a proton-pumping peroxidase: reaction cycle and electrogenic mechanism.

1998 • 46 citations

Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells

2010 • 45 citations

Chloride Bound to Oxidized Cytochrome c Oxidase Controls the Reaction with Nitric Oxide

1998 • 44 citations

A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase

2011 • 43 citations

An EPR study of the photodissociation reactions of oxidised cytochrome c oxidase-nitric oxide complexes

1983 • 43 citations

Reaction of nitric oxide with the oxidized di-heme and heme–copper oxygen-reducing centers of terminal oxidases: Different reaction pathways and end-products

2009 • 42 citations

Electron and proton transfer in the ba 3 oxidase from Thermus thermophilus

2008 • 38 citations

Reaction mechanism of bovine heart cytochrome c oxidase

2006 • 38 citations

A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase

2008 • 36 citations

Nitric oxide, cytochrome c oxidase and myoglobin: Competition and reaction pathways

2005 • 36 citations

Isoforms of human cytochrome‐c oxidase

1991 • 34 citations

Fast Deuterium Access to the Buried Magnesium/Manganese Site in CytochromecOxidase

2001 • 34 citations

A cytochrome c oxidase proton pumping mechanism that excludes the O₂ reduction site

2003 • 33 citations

Nitric oxide and oxygen utilization

1999 • 33 citations

Control of respiration by nitric oxide in Keilin-Hartree particles, mitochondria and SH-SY5Y neuroblastoma cells

2003 • 32 citations

Oxygen influences the subunit structure of cytochrome c oxidase in the slime mold Dictyostelium discoideum

1989 • 32 citations

Cytochrome bd, a key oxidase in bacterial survival and tolerance to nitrosative stress.

2007 • 32 citations

Nitric Oxide Reacts with the Single-electron Reduced Active Site of Cytochrome c Oxidase

2002 • 32 citations

A resonance Raman band assignable to the O–O stretching mode in the resting oxidized state of bovine heart cytochrome c oxidase

2010 • 31 citations

The steady-state mechanism of cytochrome c oxidase: redox interactions between metal centres

2009 • 30 citations

Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells

2004 • 30 citations

Electron entry in a Cu_A mutant of cytochrome c oxidase from Paracoccus denitrificans. Conclusive evidence on the initial electron entry metal center

1998 • 28 citations

EPR Evidence of Cyanide Binding to the Mn(Mg) Center of Cytochrome c Oxidase: Support for Cu_A−Mg Involvement in Proton Pumping

2008 • 27 citations

CytochromecOxidase as a Calcium Binding Protein. Studies on the Role of a Conserved Aspartate in Helices XI−XII Cytoplasmic Loop in Cation Binding

2005 • 26 citations

Heme‐Copper Oxidases and Their Electron Donors in Cyanobacterial Respiratory Electron Transport

2008 • 23 citations

Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions

2009 • 20 citations

Asp‐193 and Glu‐218 of subunit II are involved in the Mn²⁺‐binding of Paracoccus denitrificans cytochrome c oxidase

1997 • 20 citations

X-ray structure of the NO-bound Cu_Bin bovine cytochromecoxidase

2010 • 18 citations

Control of cell respiration by nitric oxide in Ataxia Telangiectasia lymphoblastoid cells

2007 • 10 citations