Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

Free radicals and antioxidants in normal physiological functions and human disease

2006 • 13,251 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

The BCL-2 protein family: opposing activities that mediate cell death

2007 • 4,342 citations

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

2006 • 3,685 citations

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

2008 • 3,605 citations

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

2005 • 3,368 citations

Regulation Mechanisms and Signaling Pathways of Autophagy

2009 • 3,366 citations

Loss of autophagy in the central nervous system causes neurodegeneration in mice

2006 • 3,331 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

NAD(P)H Oxidase

2000 • 2,902 citations

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

2010 • 2,610 citations

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

2010 • 2,550 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

p53 in health and disease

2007 • 2,088 citations

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

2006 • 1,840 citations

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

2009 • 1,502 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

2006 • 1,371 citations

The BCL-2 Family Reunion

2010 • 1,350 citations

Mitochondrial metabolism of reactive oxygen species

2005 • 1,283 citations

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

2008 • 1,243 citations

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

2006 • 1,113 citations

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

2009 • 1,083 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1

2007 • 1,058 citations

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

2006 • 1,035 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane

2004 • 983 citations

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

2008 • 979 citations

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

2002 • 965 citations

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

2004 • 959 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

1997 • 822 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

2003 • 791 citations

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

2008 • 783 citations

ROS and p53: A versatile partnership

2008 • 769 citations

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

2003 • 761 citations

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

2006 • 754 citations

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

2004 • 750 citations

Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2005 • 703 citations

NADPH Oxidases, Reactive Oxygen Species, and Hypertension

2008 • 675 citations

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

2006 • 662 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

NADPH Oxidases: Functions and Pathologies in the Vasculature

2009 • 566 citations

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

2007 • 542 citations

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

2001 • 490 citations

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

2001 • 459 citations

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

2005 • 427 citations

Reactive Oxygen Species in Mitochondria-Mediated Cell Death

2007 • 421 citations

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

2007 • 420 citations

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

2008 • 406 citations

An attempt to prevent senescence: A mitochondrial approach

2008 • 403 citations

Therapeutic Effects of Coenzyme Q₁₀and Remacemide in Transgenic Mouse Models of Huntington's Disease

2002 • 391 citations

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

2006 • 391 citations

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

2004 • 374 citations

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

2009 • 370 citations

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

2010 • 362 citations

Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants

2003 • 349 citations

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

2010 • 344 citations

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

2010 • 333 citations

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

2009 • 294 citations

Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

1999 • 254 citations

Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease

1997 • 253 citations

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials

2006 • 250 citations

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

2001 • 244 citations

Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice

2005 • 242 citations

Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

2005 • 234 citations

Does autophagy have a license to kill mammalian cells?

2008 • 233 citations

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

2008 • 225 citations

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

2004 • 221 citations

Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

1998 • 216 citations

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

2009 • 202 citations

Circulating xanthine oxidase: potential mediator of ischemic injury

1990 • 188 citations

Hydrogen peroxide activates IκB kinases through phosphorylation of serine residues in the activation loops

2002 • 179 citations

The NADPH Oxidase of Endothelial Cells

2000 • 177 citations

Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells

1995 • 174 citations

Increased Formation of Reactive Oxygen Species, but No Changes in Glutathione Peroxidase Activity, in Striata of Mice Transgenic for the Huntington's Disease Mutation

2004 • 161 citations

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

2006 • 160 citations

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

2009 • 158 citations

Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis

2009 • 145 citations

The NADPH Oxidase of Endothelial Cells

2000 • 138 citations

Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium

2006 • 137 citations

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

2008 • 130 citations

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

2009 • 130 citations

Oxidative Stress Involvement inα-Synuclein Oligomerization in Parkinson's Disease Cybrids

2008 • 129 citations

DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

2008 • 128 citations

Hypoxia‐inducible factor 1: a new hope to counteract neurodegeneration?

2009 • 123 citations

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

2002 • 123 citations

Mitochondria‐Targeted Antioxidants in the Treatment of Disease

2008 • 112 citations

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

2009 • 99 citations

Mitochondrial dysfunction in movement disorders

1994 • 90 citations

Mitochondrial dynamics, cell death and the pathogenesis of Parkinson’s disease

2010 • 86 citations

Protective Effects of Mitochondria-Targeted Antioxidant SkQ in Aqueous and Lipid Membrane Environments

2008 • 82 citations

Caspase-Independent Programmed Cell Death Following Ischemic Stroke

2008 • 80 citations

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

2006 • 78 citations

Mutant SOD1‐induced neuronal toxicity is mediated by increased mitochondrial superoxide levels

2007 • 61 citations

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

2006 • 39 citations

Targeting the Mitochondria for Cancer Therapy: Regulation of Hypoxia-Inducible Factor by Mitochondria

2007 • 29 citations