The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

The versatility and universality of calcium signalling

2000 • 5,407 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Mitochondrial Oxidative Stress: Implications for Cell Death

2006 • 1,212 citations

Mitochondria and calcium: from cell signalling to cell death

2000 • 1,192 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

A Dissection and tissue culture manual of the nervous system

1989 • 762 citations

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2005 • 703 citations

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 • 624 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

2003 • 547 citations

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

1999 • 530 citations

The unfolded protein response is activated in Alzheimer’s disease

2005 • 524 citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1999 • 521 citations

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.

2002 • 516 citations

Endoplasmic reticulum of animal cells and its organization into structural and functional domains

2001 • 442 citations

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

2003 • 390 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Amyloid precursor protein‐mediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer's disease

2005 • 347 citations

Enhanced Ryanodine Receptor Recruitment Contributes to Ca²⁺Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

2006 • 316 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Molecular biology and pathogenesis of prion diseases

1996 • 279 citations

Dysregulated IP₃Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca²⁺Signals and Altered Membrane Excitability

2004 • 268 citations

Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases

2004 • 255 citations

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: CytochromecRelease and a Secondary Increase in Superoxide Production

2000 • 233 citations

Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

2000 • 221 citations

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

2006 • 200 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

Functional mitochondria are required for amyloid β‐mediated neurotoxicity

2001 • 198 citations

The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity

2005 • 198 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Biology of Aβ Amyloid in Alzheimer's Disease

1997 • 187 citations

The mouse MPTP model: gene expression changes in dopaminergic neurons

2003 • 165 citations

Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

1999 • 161 citations

Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states

2001 • 152 citations

Control of apoptosis by IP3and ryanodine receptor driven calcium signals

2000 • 151 citations

Prion Protein Fragment PrP-(106–126) Induces Apoptosis via Mitochondrial Disruption in Human Neuronal SH-SY5Y Cells

2001 • 150 citations

Involvement of endoplasmic reticulum Ca²⁺ release through ryanodine and inositol 1,4,5‐triphosphate receptors in the neurotoxic effects induced by the amyloid‐β peptide

2004 • 149 citations

The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death

2002 • 140 citations

Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation

1983 • 135 citations

Involvement of calcineurin in the neurotoxic effects induced by amyloid‐beta and prion peptides

2003 • 89 citations

Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats

2005 • 87 citations

Early and Late Cytotoxic Effects of External Application of the Alzheimer's Aβ Result from the Initial Formation and Function of Aβ Ion Channels

2006 • 66 citations

Depletion of Glutathione by Benzo(a)pyrene Metabolites, Ionomycin, Thapsigargin, and Phorbol Myristate in Human Peripheral Blood Mononuclear Cells

1997 • 62 citations

Continuous monitoring of mitochondrial membrane potential in hepatocyte cell suspensions

1996 • 58 citations

GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells

2004 • 56 citations

Involvement of mitochondria in endoplasmic reticulum stress‐induced apoptotic cell death pathway triggered by the prion peptide PrP_106–126

2007 • 51 citations

Bcl-2 Overexpression Protects Against Amyloid-Beta and Prion Toxicity in GT1-7 Neural Cells

2007 • 39 citations

Calcium signalling: Ringing changes to the ‘bell-shaped curve’

1999 • 39 citations