Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

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A synaptic model of memory: long-term potentiation in the hippocampus

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Alzheimer's Disease: Genes, Proteins, and Therapy

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Short-Term Synaptic Plasticity

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Alzheimer's Disease Is a Synaptic Failure

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Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

APP Processing and Synaptic Function

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Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

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Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

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Intraneuronal Aβ42 Accumulation in Human Brain

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

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Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

2001 • 666 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

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Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

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The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

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Tau Filament Formation in Transgenic Mice Expressing P301L Tau

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Neuroplasticity Failure in Alzheimer's Disease

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Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

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Correlations of synaptic and pathological markers with cognition of the elderly

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Facilitation, augmentation and potentiation at central synapses

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

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Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

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Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

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Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

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Genetically engineered mouse models of neurodegenerative diseases

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Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 230 citations

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

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Amyloid Filaments in Inclusion Body Myositis

1991 • 205 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

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Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration

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Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.

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A Plasticity‐Based Theory of the Pathogenesis of Alzheimer's Disease

2000 • 131 citations

Synaptic Transmission and Hippocampal Long-Term Potentiation in Transgenic Mice Expressing FAD-Linked Presenilin 1

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Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle

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The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease

2001 • 92 citations

Chapter 31 Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease

1990 • 83 citations

Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice

1999 • 73 citations

Quantitation of synaptic density in the septal nuclei of young and aged Fischer 344 rats

1991 • 56 citations

Aβ42-Carboxy-Terminal-like Immunoreactivity Is Associated with Intracellular Neurofibrillary Tangles and Pick Bodies

2000 • 15 citations