Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2006 • 5,824 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

2004 • 2,165 citations

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

2005 • 1,779 citations

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

1996 • 1,320 citations

Mitochondrial Abnormalities in Alzheimer's Disease

2001 • 1,319 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

2001 • 1,091 citations

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

2009 • 1,083 citations

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

2006 • 1,058 citations

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

2006 • 1,035 citations

Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials

2004 • 949 citations

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

2008 • 875 citations

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

2008 • 874 citations

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

2009 • 865 citations

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

2008 • 783 citations

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

2001 • 776 citations

Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial Dysfunction

2006 • 759 citations

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

2011 • 719 citations

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2005 • 703 citations

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

2010 • 657 citations

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

2008 • 635 citations

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

2009 • 604 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

2011 • 574 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

Mitochondria: The Next (Neurode)Generation

2011 • 541 citations

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

2004 • 537 citations

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

2000 • 459 citations

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

2010 • 431 citations

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

2004 • 398 citations

Targeting antioxidants to mitochondria: A new therapeutic direction

2005 • 397 citations

Vitamin E for Alzheimer's dementia and mild cognitive impairment

2017 • 396 citations

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

2002 • 364 citations

Vitamin E and Cognitive Decline in Older Persons

2002 • 342 citations

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

1998 • 337 citations

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

2008 • 326 citations

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

2010 • 324 citations

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

2003 • 314 citations

Copper-Dependent Inhibition of Human CytochromecOxidase by a Dimeric Conformer of Amyloid-β_1-42

2005 • 314 citations

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

2004 • 313 citations

Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents

2006 • 308 citations

Cell-permeable, mitochondrial-targeted, peptide antioxidants

2006 • 298 citations

Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change

2005 • 297 citations

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

2008 • 297 citations

Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

2003 • 292 citations

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

2005 • 280 citations

Mitochondria and Cancer: Warburg Addressed

2005 • 278 citations

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

2004 • 274 citations

Acute Impairment of Mitochondrial Trafficking by β-Amyloid Peptides in Hippocampal Neurons

2006 • 240 citations

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment

2003 • 234 citations

Mitochondrial trafficking and morphology in healthy and injured neurons

2006 • 225 citations

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

2011 • 223 citations

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

2008 • 216 citations

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

2009 • 215 citations

A phase II trial of huperzine A in mild to moderate Alzheimer disease

2011 • 209 citations

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

2011 • 207 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

Qualitative Estimates of Medial Temporal Atrophy as a Predictor of Progression From Mild Cognitive Impairment to Dementia

2007 • 200 citations

Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

2004 • 194 citations

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases

2010 • 188 citations

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

2010 • 182 citations

Mitochondrial Dysfunction in Aging and Alzheimer's Disease: Strategies to Protect Neurons

2007 • 181 citations

Vitamin C and Vitamin E for Alzheimer's Disease

2005 • 171 citations

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

2009 • 168 citations

A Novel Cell-permeable Antioxidant Peptide, SS31, Attenuates Ischemic Brain Injury by Down-regulating CD36

2006 • 164 citations

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

2006 • 160 citations

Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology

2006 • 149 citations

Mitochondrial Oxidative Damage in Aging and Alzheimer′s Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics

2006 • 149 citations

Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

2010 • 145 citations

Donepezil delays progression to AD in MCI subjects with depressive symptoms

2009 • 143 citations

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

2008 • 142 citations

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

2007 • 137 citations

Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury

2011 • 137 citations

Vitamin E for Alzheimer's disease and mild cognitive impairment

2008 • 126 citations

Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

2010 • 124 citations

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

2011 • 122 citations

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

2010 • 120 citations

Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells

2008 • 116 citations

The Neurodegenerative Mitochondriopathies

2009 • 114 citations

Statin therapy in Alzheimer's disease

2006 • 103 citations

Effects of α-tocopherol on an animal model of tauopathies

2004 • 97 citations

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort

2010 • 96 citations

Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases

2008 • 90 citations

Reduced Mitochondria Cytochrome Oxidase Activity in Adult Children of Mothers with Alzheimer's Disease

2011 • 88 citations

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

2010 • 79 citations

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

2006 • 78 citations

Aluminum Modulates Effects ofβAmyloid_1–42on Neuronal Calcium Homeostasis and Mitochondria Functioning and Is Altered in a Triple Transgenic Mouse Model of Alzheimer's Disease

2008 • 74 citations

Nuclear-encoded mitochondrial proteins and their role in cardioprotection

2011 • 72 citations

Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease, Tardive Dyskinesia, and Cataract: Part 2

2005 • 71 citations

Determinants of platelet activation in Alzheimer's disease

2006 • 70 citations

Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure

2011 • 65 citations

The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics

2011 • 55 citations

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

2011 • 53 citations

Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca

2011 • 48 citations

Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer’s disease

2007 • 47 citations

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

2011 • 31 citations

Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC+ for Mild Cognitive Impairment Clinical Trials

2009 • 25 citations

Deleted Work

1955 • 0 citations