A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1991 • 1,344 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

2003 • 1,027 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

2002 • 679 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

2002 • 491 citations

The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

2000 • 479 citations

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1997 • 443 citations

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

2004 • 434 citations

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

2002 • 416 citations

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

2001 • 385 citations

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

2002 • 377 citations

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

2003 • 367 citations

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

1999 • 362 citations

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

2004 • 343 citations

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

2001 • 337 citations

Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42

1997 • 302 citations

Oxidative Stress Induces Intracellular Accumulation of Amyloid β-Protein (Aβ) in Human Neuroblastoma Cells

2000 • 295 citations

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

1998 • 285 citations

Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 • 278 citations

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid A?1-42 pathogenesis

1998 • 277 citations

Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice

2003 • 276 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 271 citations

Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1997 • 271 citations

Intraneuronal Aβ42 accumulation in Down syndrome brain

2002 • 251 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 230 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

Intracellular Amyloid-β1–42, but Not Extracellular Soluble Amyloid-β Peptides, Induces Neuronal Apoptosis

2002 • 184 citations

Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease

2001 • 184 citations

Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

2001 • 176 citations

Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

1996 • 167 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

Cell death mechanisms in neurodegeneration

2001 • 160 citations

Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells

2000 • 145 citations

Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease.

2004 • 122 citations

Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice

2002 • 119 citations

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein.

1998 • 115 citations

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

1997 • 110 citations

Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging

1999 • 102 citations

Presenilins are not required for Aβ42 production in the early secretory pathway

2002 • 100 citations

Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein

1995 • 100 citations

Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts

2001 • 97 citations

Amyloid ? protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

1998 • 86 citations

Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

2003 • 82 citations

Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

2002 • 75 citations

Apoptotic neurons in Alzheimer's disease frequently show intracellular Aβ42 labeling

2001 • 73 citations

Selective increase in cellular Aβ42 is related to apoptosis but not necrosis

2000 • 70 citations

Alzheimer β-Amyloid Homodimers Facilitate Aβ Fibrillization and the Generation of Conformational Antibodies

2003 • 69 citations

Presenilin 1 Mutations Linked to Familial Alzheimer's Disease Increase the Intracellular Levels of Amyloid β‐Protein 1–42 and Its N‐Terminally Truncated Variant(s) Which Are Generated at Distinct Sites

1998 • 67 citations

Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi

2004 • 65 citations

Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2

2004 • 54 citations

Relationship between Clinical and Radiological Diagnostic Criteria for Alzheimer’s Disease and the Extent of Neuropathology as Reflected by ‘Stages’: A Prospective Study

1999 • 51 citations

The use of formic acid to embellish amyloid plaque detection in Alzheimer's disease tissues misguides key observations

2003 • 50 citations

Rapid cellular uptake of Alzheimer amyloid βA4 peptide by cultured human neuroblastoma cells

1996 • 50 citations

Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by Bcl-2 and Bcl-XL

1997 • 45 citations

γ-Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid β

2003 • 39 citations

Distinct Mechanisms by Mutant Presenilin 1 and 2 Leading to Increased Intracellular Levels of Amyloid β-Protein 42 in Chinese Hamster Ovary Cells

2003 • 38 citations

Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines

2002 • 33 citations

Aβ42-Carboxy-Terminal-like Immunoreactivity Is Associated with Intracellular Neurofibrillary Tangles and Pick Bodies

2000 • 15 citations