Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

1997 • 938 citations

Cancer risk and oxidative DNA damage in man

1996 • 936 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

1992 • 474 citations

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

1998 • 467 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

1994 • 321 citations

[2] Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection

1994 • 303 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Cerebrospinal fluid F₂‐isoprostane levels are increased in Alzheimer's disease

1998 • 241 citations

Regional brain trace-element studies in Alzheimer's disease.

1988 • 231 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Brain trace elements in Alzheimer's disease.

1986 • 194 citations

Quantitative determination of oxidative base damage in DNA by stable isotope‐dilution mass spectrometry

1993 • 153 citations

An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA

1991 • 149 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

Elemental imbalances in the olfactory pathway in Alzheimer's disease

1995 • 113 citations

An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA

1991 • 84 citations

Food additives as a source of behavioral disturbances in children.

1986 • 81 citations

8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease

1996 • 45 citations

Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8‐Hydroxyguanine (7,8‐Dihydro‐8‐oxoguanine) in Hot Spots of the c‐Ha‐ras Gene

1995 • 31 citations