Cortical biochemistry in MCI and Alzheimer disease

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Vascular dementia

1993 • 4,707 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

2004 • 4,596 citations

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)

1996 • 3,940 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease

2001 • 1,786 citations

Tangles and plaques in nondemented aging and ?preclinical? Alzheimer's disease

1999 • 1,648 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Clinical and Pathological Diagnosis of Frontotemporal Dementia

2001 • 1,445 citations

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

2000 • 1,259 citations

Natural history of mild cognitive impairment in older persons

2002 • 970 citations

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

1997 • 938 citations

Mild Cognitive Impairment as a Clinical Entity and Treatment Target

2005 • 867 citations

Mild cognitive impairment in the elderly

1991 • 814 citations

Individual differences in rates of change in cognitive abilities of older persons.

2002 • 774 citations

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

2002 • 676 citations

Neuropathology of Cognitively Normal Elderly

2003 • 630 citations

Neuropathologic Features of Amnestic Mild Cognitive Impairment

2006 • 609 citations

Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment

2003 • 555 citations

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

1999 • 548 citations

Evidence of increased oxidative damage in subjects with mild cognitive impairment

2005 • 533 citations

Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions

2005 • 517 citations

Neuropathologic Substrate of Mild Cognitive Impairment

2006 • 459 citations

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

1994 • 455 citations

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment

2001 • 427 citations

Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease

1997 • 422 citations

Increased F₂‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidationin vivo

1998 • 411 citations

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

2005 • 377 citations

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

2005 • 273 citations

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease

2002 • 249 citations

Cerebrospinal fluid F₂‐isoprostane levels are increased in Alzheimer's disease

1998 • 241 citations

Entorhinal Cortex β-Amyloid Load in Individuals with Mild Cognitive Impairment

1999 • 232 citations

Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease

2002 • 185 citations

Alzheimer’s disease and oxygen radicals: new insights

2002 • 183 citations

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease

2002 • 171 citations

Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

1996 • 167 citations

Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease

2005 • 152 citations

Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease

2002 • 152 citations

Oxidative Imbalance in Alzheimer's Disease

2005 • 143 citations

Preservation of Brain Nerve Growth Factor in Mild Cognitive Impairment and Alzheimer Disease

2003 • 60 citations

Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex

2005 • 25 citations

Assessment of Pathological Tau Proteins in Frontotemporal Dementias: Qualitative and Quantitative Approaches

2004 • 21 citations