DNA strand breaks in Alzheimer's disease

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period

1998 • 532 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

1998 • 467 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death

1997 • 312 citations

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons.

1997 • 286 citations

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

1999 • 283 citations

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease

1999 • 246 citations

Monoclonal Antibody to Single-Stranded DNA Is a Specific and Sensitive Cellular Marker of Apoptosis

1996 • 241 citations

Bax Protein Expression Is Increased in Alzheimerʼs Brain

1997 • 241 citations

Neuropathology of Alzheimer’s disease: a critical update

1998 • 231 citations

Reactive oxygen species and Alzheimer's disease

1997 • 228 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

Alzheimer Disease

1998 • 211 citations

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

1990 • 196 citations

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

1997 • 175 citations

Mechanisms of synaptic dysfunction in Alzheimer's disease.

1995 • 170 citations

Caspase Dependent DNA Fragmentation Might Be Associated with Excitotoxicity in Alzheimer Disease

1998 • 155 citations

β-Amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells

1996 • 151 citations

On the question of apoptosis in the parkinsonian substantia nigra

1997 • 145 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures

1996 • 136 citations

An Improved Approach to Prepare Human Brains for Research

1995 • 130 citations

Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and alzheimer patients

1997 • 118 citations

Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons.

1997 • 114 citations

Hippocampal connectivity and Alzheimer's dementia

1994 • 100 citations

Neuronal Apoptosis and Necrosis Following Spinal Cord Ischemia in the Rat

1997 • 97 citations

Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum

1998 • 95 citations

In Situ Labeling of Dying Cortical Neurons in Normal Aging and in Alzheimer's Disease: Correlations with Senile Plaques and Disease Progression

1996 • 94 citations

DNA strand breaks in rat tissues as detected by in situ nick translation

1986 • 89 citations

Kainic acid induces apoptosis in neurons

1996 • 88 citations

In Situ Detection of Neuronal DNA Strand Breaks Using the Klenow Fragment of DNA Polymerase I Reveals Different Mechanisims of Neuron Death After Global Cerebral Ischemia

1999 • 79 citations

Progressive Neuronal Injury Associated with Amyloid Plaque Formation in Alzheimer Disease

1998 • 78 citations

Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man

1998 • 61 citations

Production of Reactive Oxygen Species and Release of <scp>l</scp>‐Glutamate During Superoxide Anion‐Induced Cell Death of Cerebellar Granule Neurons

1998 • 59 citations

Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: Comparison with early DNA damage

1998 • 52 citations

Progressive Neuronal DNA Damage Associated with Neurofibrillary Tangle Formation in Alzheimer Disease

1998 • 52 citations

Nuclear DNA fragmentation in Creutzfeldt-Jakob disease: does a mere positive in situ nuclear end-labeling indicate apoptosis?

1999 • 51 citations

Mechanisms of cell death in Alzheimer’s disease

1997 • 50 citations

Single stranded DNA as an immunocytochemical marker for apoptotic change of ischemia in the gerbil hippocampus

1998 • 49 citations

β-Amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield

1998 • 45 citations

DNA breaks detected by in situ end‐labelling in dorsal root ganglia of patients with AIDS

1998 • 27 citations

Comparison of Two Methods of Staining Apoptotic Cells of Leukemia Cell Lines: Terminal Deoxynucleotidyl Transferase and DNA Polymerase I Reactions

1998 • 15 citations

Alzheimer's disease: therapeutic strategies for the 1990s

1994 • 11 citations