PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

2003 • 1,140 citations

Protein Oxidation

2000 • 935 citations

Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples

1990 • 901 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

2003 • 735 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

2002 • 658 citations

The unfolded protein response in nutrient sensing and differentiation

2002 • 592 citations

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

2003 • 587 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

2002 • 564 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

2001 • 454 citations

Stress-induced gene expression requires programmed recovery from translational repression

2003 • 450 citations

Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium

2003 • 447 citations

Transcriptional Regulation of the Antioxidant Response Element

2000 • 364 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

[27] Isolation of human cell lines lacking mitochondrial DNA

1996 • 356 citations

ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1

2000 • 345 citations

Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy.

2000 • 343 citations

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

2001 • 323 citations

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

2000 • 317 citations

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

2000 • 309 citations

NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons

2003 • 303 citations

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

2003 • 300 citations

Glutathione synthesis is essential for mouse development but not for cell growth in culture

2000 • 277 citations

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase

1999 • 254 citations

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

1996 • 202 citations

The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents

1999 • 176 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

Metabolic Imaging in Multicellular Spheroids of Oncogene-transfected Fibroblasts

2000 • 104 citations

Induction of glucose regulated proteins during growth of a murine tumor

1993 • 57 citations

Role of N-linked glycosylation in cell-cycle progression and initiation of DNA synthesis in tumor-transformed human fibroblasts.

1993 • 19 citations