Toxicity of β-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-d-aspartate receptor subunits

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Memantine in Moderate-to-Severe Alzheimer's Disease

2003 • 1,889 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease

2004 • 866 citations

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

2003 • 801 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease

2002 • 603 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1999 • 483 citations

NMDA receptor pathways as drug targets

2002 • 470 citations

Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases.

2003 • 453 citations

Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

1996 • 291 citations

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

2000 • 283 citations

β‐Amyloid neurotoxicity is mediated by a glutamate‐triggered excitotoxic cascade in rat nucleus basalis

2000 • 271 citations

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

2003 • 270 citations

Regulation of NMDA receptors by cyclin-dependent kinase-5

2001 • 255 citations

Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Disease^a

1994 • 254 citations

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

1998 • 254 citations

β-Amyloid-induced Dynamin 1 Degradation Is Mediated by N-Methyl-D-Aspartate Receptors in Hippocampal Neurons

2006 • 241 citations

Regulation of the apoptosis–necrosis switch

2004 • 235 citations

Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death

1999 • 224 citations

Amyloid β peptide induces necrosis rather than apoptosis

1994 • 221 citations

Developmental Changes in NMDA Neurotoxicity Reflect Developmental Changes in Subunit Composition of NMDA Receptors

2006 • 196 citations

Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes

2002 • 195 citations

Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurons

1999 • 178 citations

Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology

2003 • 149 citations

N-Methyl-d-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer’s disease

2001 • 148 citations

Peroxisomal Proliferation Protects from β-Amyloid Neurodegeneration

2005 • 140 citations

Selective Activation Induced Cleavage of the NR2B Subunit by Calpain

2003 • 139 citations

NMDA Receptor Pharmacology: Perspectives from Molecular Biology

2001 • 122 citations

Differential expression of N‐methyl‐<scp>d</scp>‐aspartate receptor NR2 isoforms in Alzheimer's disease

2004 • 106 citations

Attenuation of Focal Ischemic Brain Injury in Mice Deficient in the ε1 (NR2A) Subunit of NMDA Receptor

1998 • 97 citations

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2

2002 • 97 citations

Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons

1995 • 91 citations

NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology.

1997 • 87 citations

Transfection of N‐Methyl‐<scp>d</scp>‐Aspartate Receptors in a Nonneuronal Cell Line Leads to Cell Death

1995 • 82 citations

Proteolysis of theN-Methyl-d-Aspartate Receptor by Calpain in Situ

2002 • 80 citations

N-Methyl- -Aspartate Receptor Antagonist MK-801 and Radical Scavengers Protect Cholinergic Nucleus Basalis Neurons against β-Amyloid Neurotoxicity

1999 • 72 citations

Effects of beta-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor.

1997 • 70 citations

Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

2003 • 70 citations

Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.

1996 • 64 citations

FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

2004 • 61 citations

Increased agonist and antagonist sensitivity of N-methyl-d-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure

1995 • 55 citations

Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor

2006 • 47 citations

N-Methyl-d-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production

2000 • 40 citations

Ultrastructure evidence of necrotic neural cell death in familial Alzheimer's disease brains bearing presenilin-1 E280A mutation1

2001 • 38 citations

Developmental and cell‐selective variations in N‐methyl‐<scp>d</scp>‐aspartate receptor degradation by calpain

2006 • 37 citations

Adenosine Triphosphate Degradation Products After Oxidative Stress and Metabolic Dysfunction in Cultured Retinal Cells

1997 • 34 citations

Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease

1991 • 32 citations

Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress

2000 • 14 citations

β-amyloid related peptides exert differential effects on [3H]MK-801 binding to rat cortical membranes

1994 • 14 citations