“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Progressive Multifocal Leukoencephalopathy Complicating Treatment with Natalizumab and Interferon Beta-1a for Multiple Sclerosis

2005 • 1,060 citations

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

2006 • 1,043 citations

Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab

2005 • 1,033 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Molecular machinery for non-vesicular trafficking of ceramide

2003 • 994 citations

The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind

2002 • 895 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

2007 • 861 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

2005 • 606 citations

De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway

2002 • 603 citations

Discovery and evaluation of inhibitors of human sphingosine kinase.

2003 • 586 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 578 citations

Finding a way out: lymphocyte egress from lymphoid organs

2007 • 573 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors

2004 • 532 citations

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

1994 • 532 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function

2004 • 462 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

2006 • 443 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Physiology and pathophysiology of sphingolipid metabolism and signaling

2000 • 427 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

2006 • 406 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

2007 • 398 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/Reperfusion Injury In Vivo via the S1P ₃ Lysophospholipid Receptor

2006 • 394 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

2007 • 383 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

1990 • 369 citations

Erythrocytes store and release sphingosine 1‐phosphate in blood

2007 • 355 citations

Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

2005 • 325 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Sphingosine Kinase-1 Expression Correlates With Poor Survival of Patients With Glioblastoma Multiforme: Roles of Sphingosine Kinase Isoforms in Growth of Glioblastoma Cell Lines

2005 • 321 citations

The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE₂production in response to TNF‐α

2003 • 318 citations

Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

2001 • 318 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Ceramide Kinase, a Novel Lipid Kinase

2002 • 292 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Autocrine and paracrine roles of sphingosine-1-phosphate

2007 • 291 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment

2003 • 281 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Sphingosine Kinase: Biochemical and Cellular Regulation and Role in Disease

2006 • 273 citations

Regulation of sphingosine 1‐phosphate‐induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P₁receptor, PI3 kinase, Tiam1/Rac1, and α‐actinin

2005 • 273 citations

First Human Trial of FTY720, a Novel Immunomodulator, in Stable Renal Transplant Patients

2002 • 272 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Sphingosine 1-Phosphate Analogs as Receptor Antagonists

2004 • 267 citations

Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis

2007 • 264 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

2004 • 261 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G_12/13-Rho and G_i Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

2003 • 259 citations

Antitumor Activity of Sphingosine Kinase Inhibitors

2006 • 239 citations

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

2005 • 235 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells

2002 • 227 citations

Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney

2006 • 226 citations

Lysophospholipid receptor nomenclature

2002 • 225 citations

Regulation and functional roles of sphingosine kinases

2007 • 223 citations

Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

2004 • 221 citations

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

2006 • 220 citations

Sphingosine kinase 1 is up‐regulated in colon carcinogenesis

2005 • 218 citations

FTY720, A Novel Immunomodulator: Efficacy and Safety Results from the First Phase 2A Study in de novo Renal Transplantation

2004 • 216 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation

2006 • 205 citations

Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid

2004 • 205 citations

The Sphingosine Kinase-Sphingosine-1-Phosphate Axis Is a Determinant of Mast Cell Function and Anaphylaxis

2007 • 200 citations

Essential Roles of Sphingosine 1-Phosphate/S1P1 Receptor Axis in the Migration of Neural Stem Cells Toward a Site of Spinal Cord Injury

2006 • 199 citations

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF‐7 human breast cancer cells

2005 • 199 citations

Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models

2005 • 198 citations

Functions of a new family of sphingosine-1-phosphate receptors

2000 • 194 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Endothelial cell barrier regulation by sphingosine 1‐phosphate

2004 • 189 citations

Sphingosine 1-phosphate: synthesis and release

2001 • 187 citations

Oxidative Stress–Dependent Sphingosine Kinase-1 Inhibition Mediates Monoamine Oxidase A–Associated Cardiac Cell Apoptosis

2006 • 187 citations

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

2007 • 182 citations

An essential role for the H218/AGR16/Edg‐5/LP_B2 sphingosine 1‐phosphate receptor in neuronal excitability

2001 • 182 citations

Enzymatic Measurement of Sphingosine 1-Phosphate

1999 • 182 citations

Critical role of ABCA1 transporter in sphingosine 1‐phosphate release from astrocytes

2007 • 180 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

Immunohistochemical Distribution of Sphingosine Kinase 1 in Normal and Tumor Lung Tissue

2005 • 176 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1

2005 • 172 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

The Heart Rate Decrease Caused by Acute FTY720 Administration Is Mediated by the G Protein-Gated Potassium Channel IKACh

2005 • 162 citations

N,N-Dimethylsphingosine Inhibition of Sphingosine Kinase and Sphingosine 1-Phosphate Activity in Human Platelets

1996 • 162 citations

Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation

2007 • 159 citations

Sphingolipid transport in eukaryotic cells

2000 • 159 citations

Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor

2005 • 157 citations

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

2005 • 157 citations

Alkaline sphingomyelinase: An old enzyme with novel implications

2006 • 155 citations

Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin

2007 • 154 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

Tipping the gatekeeper: S1P regulation of endothelial barrier function

2007 • 150 citations

Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts.

1989 • 149 citations

Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells

2003 • 149 citations

FTY720 versus MMF with Cyclosporine in de novo Renal Transplantation: A 1-Year, Randomized Controlled Trial in Europe and Australasia

2006 • 147 citations

Loss of sphingosine kinase‐1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis

2005 • 145 citations

Protein Kinase D-mediated Phosphorylation and Nuclear Export of Sphingosine Kinase 2

2007 • 142 citations

Type 4 sphingosine 1‐phosphate G protein‐coupled receptor (S1P₄) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration

2005 • 141 citations

IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses

2005 • 140 citations

Sphingosine Kinase 1 Regulates Differentiation of Human and Mouse Lung Fibroblasts Mediated by TGF-β1

2007 • 140 citations

The Mechanism of Membrane Targeting of Human Sphingosine Kinase 1

2005 • 138 citations

Cardiovascular effects of sphingosine‐1‐phosphate and other sphingomyelin metabolites

2004 • 137 citations

Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors

2004 • 137 citations

Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography–tandem mass spectrometry

2004 • 136 citations

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

2005 • 136 citations

Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate

2002 • 129 citations

Down-regulation of Sphingosine Kinase-1 by DNA Damage

2004 • 129 citations

The S1P₂ Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation

2005 • 127 citations

S1P₃receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF

2005 • 126 citations

Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study

2003 • 126 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure

2006 • 123 citations

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

1991 • 123 citations

Analysis of sphingosine 1‐phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools

2007 • 120 citations

KRP-203, a Novel Synthetic Immunosuppressant, Prolongs Graft Survival and Attenuates Chronic Rejection in Rat Skin and Heart Allografts

2005 • 119 citations

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells

2003 • 119 citations

Sphingosine 1-Phosphate (S1P) Signaling Is Required for Maintenance of Hair Cells Mainly via Activation of S1P₂

2007 • 112 citations

Randomized Controlled Trial of FTY720 Versus MMF in De Novo Renal Transplantation

2006 • 107 citations

A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin.

1997 • 103 citations

A High-Performance Liquid Chromatographic Method to Measure Sphingosine 1-Phosphate and Related Compounds from Sphingosine Kinase Assays and Other Biological Samples

2000 • 103 citations

Egress: a receptor‐regulated step in lymphocyte trafficking

2003 • 102 citations

Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1

2000 • 102 citations

Pharmacodynamics of Single Doses of the Novel Immunosuppressant FTY720 in Stable Renal Transplant Patients

2003 • 102 citations

Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS

2003 • 98 citations

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

2001 • 95 citations

A Novel Sphingosine 1-Phosphate Receptor Agonist, 2-Amino-2-propanediol Hydrochloride (KRP-203), Regulates Chronic Colitis in Interleukin-10 Gene-Deficient Mice

2007 • 93 citations

Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase

2002 • 86 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 81 citations

S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells

2007 • 80 citations

A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury

2007 • 80 citations

Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells

2006 • 79 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

Therapeutic Effects of a New Lymphocyte Homing Reagent FTY720 in Interleukin-10 Gene-deficient Mice with Colitis

2004 • 73 citations

Activation of casein kinase II by sphingosine.

1991 • 70 citations

Sphingosine 1-phosphate accelerates wound healing in diabetic mice

2007 • 69 citations

Clostridium perfringens α-Toxin Activates the Sphingomyelin Metabolism System in Sheep Erythrocytes

2004 • 69 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors

2001 • 61 citations

Ceramidases in the Regulation of Ceramide Levels and Function

2004 • 60 citations

FTY720/Cyclosporine Regimens in De Novo Renal Transplantation: A 1-Year Dose-Finding Study

2006 • 59 citations

Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine

2006 • 54 citations

Use of Sphingosine-1-Phosphate 1 Receptor Agonist, KRP-203, in Combination with a Subtherapeutic Dose of Cyclosporine A for Rat Renal Transplantation

2006 • 52 citations

F-12509A, a New Sphingosine Kinase Inhibitor, Produced by a Discomycete.

2000 • 51 citations

Oral‐intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects

2007 • 50 citations

Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells

2004 • 49 citations

Toxicity of the Protein Kinase C Inhibitor Safingol Administered Alone and in Combination with Chemotherapeutic Agents

1995 • 48 citations

Mechanisms of cardioprotection by lysophospholipids

2004 • 47 citations

Sphingosine 1-phosphate: synthesis and release.

2001 • 45 citations

Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1

2005 • 43 citations

S-15183a and b, New Sphingosine Kinase Inhibitors, Produced by a Fungus.

2001 • 43 citations

Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL‐2‐independent apoptosis in human prostatic adenocarcinoma cells

2007 • 39 citations

Attenuation of Shock-Induced Acute Lung Injury by Sphingosine Kinase Inhibition

2004 • 39 citations

The immunomodulator FTY720 is phosphorylated and released from platelets

2007 • 36 citations

Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation

2006 • 36 citations

Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice

2006 • 31 citations

B-5354a, b and c, New Sphingosine Kinase Inhibitors, Produced by a Marine Bacterium. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Determination.

2000 • 29 citations

A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

1999 • 28 citations

A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis

2007 • 27 citations

Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions

2007 • 25 citations

Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen‐activated protein kinase

2007 • 21 citations

Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells

2007 • 20 citations

Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine

2006 • 18 citations

Efficacy of Mycophenolic Acid Combined With KRP-203, a Novel Immunomodulator, in a Rat Heart Transplantation Model

2006 • 17 citations

Multiple Actions of Dimethylsphingosine in 1321N1 Astrocytes

2007 • 13 citations

A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts

2005 • 11 citations