Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.

2002 • 786 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER

2004 • 500 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

2004 • 402 citations

Physiological and pathological actions of sphingosine 1-phosphate

2004 • 381 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

2002 • 305 citations

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

2004 • 261 citations

Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

2004 • 251 citations

Absorption and lipoprotein transport of sphingomyelin

2005 • 238 citations

Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1

2005 • 238 citations

Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/− compound mutant mice

2003 • 219 citations

Sphingosine kinase 1 is up‐regulated in colon carcinogenesis

2005 • 218 citations

Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

2004 • 198 citations

Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

2004 • 185 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids

2005 • 149 citations

Simultaneous Quantitative Analysis of Sphingoid Base 1-Phosphates in Biological Samples by o-Phthalaldehyde Precolumn Derivatization after Dephosphorylation with Alkaline Phosphatase

2002 • 149 citations

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae

1999 • 147 citations

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

2003 • 147 citations

Suppression of Intestinal Polyposis inApc Δ716 Knockout Mice by an Additional Mutation in the Cytosolic Phospholipase A2Gene

2000 • 142 citations

Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.

2001 • 131 citations

Sphingomyelin in the suppression of colon tumors: prevention versus intervention

2003 • 124 citations

Overexpression of Cyclooxygenase-2 Induces Cell Cycle Arrest

1999 • 114 citations

Splyregulation of sphingolipid signaling molecules is essential for Drosophila development

2003 • 114 citations

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

2003 • 95 citations

Importance of Sphingolipids and Inhibitors of Sphingolipid Metabolism as Components of Animal Diets

1997 • 90 citations

Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert

2004 • 86 citations

Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones

1997 • 85 citations

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans

2003 • 65 citations

Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster

2004 • 64 citations

The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions

1998 • 48 citations

Selective Inhibition of Herpes Simplex Virus Type-1 Uracil-DNA Glycosylase by Designed Substrate Analogs

2000 • 42 citations

Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation

2003 • 15 citations

Deleted Work

1955 • 0 citations