Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Two TNF receptors

1992 • 1,048 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr Virus LMP1 Domain Important for B-Lymphocyte Transformation: Role in NF-κB Activation

1996 • 491 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

The TNF-receptor-associated factor family

2001 • 344 citations

Insights into Programmed Cell Death through Structural Biology

2000 • 307 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

1999 • 277 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase

1998 • 239 citations

High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway

1999 • 235 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction

2000 • 185 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death

2000 • 174 citations

Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3

1997 • 171 citations

Binding Sites of Cytoplasmic Effectors TRAF1, 2, and 3 on CD30 and Other Members of the TNF Receptor Superfamily

1997 • 101 citations

Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor

1998 • 72 citations

Sphingosine-1-phosphate Mobilizes Intracellular Calcium and Activates Transcription Factor NF-κB in U937 Cells

1997 • 71 citations

Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry

2000 • 63 citations