Mechanisms of cardioprotection by lysophospholipids

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Ceramide: second messenger or modulator of membrane structure and dynamics?

2003 • 424 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Ceramide Channels Increase the Permeability of the Mitochondrial Outer Membrane to Small Proteins

2002 • 367 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

2001 • 267 citations

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria

2000 • 247 citations

Identification of a Novel Role for Sphingolipid Signaling in TNF α and Ischemic Preconditioning Mediated Cardioprotection

2002 • 233 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate

2003 • 176 citations

The Lysophospholipids Sphingosine-1-Phosphate and Lysophosphatidic Acid Enhance Survival during Hypoxia in Neonatal Rat Cardiac Myocytes

2001 • 170 citations

Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology

2001 • 167 citations

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

2002 • 163 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKCε knockout mouse hearts

2002 • 155 citations

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

2003 • 147 citations

Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid

2001 • 142 citations

GM1 ganglioside therapy in acute ischemic stroke. Italian Acute Stroke Study--Hemodilution + Drug.

1989 • 140 citations

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

2001 • 139 citations

Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1

2003 • 136 citations

Gelsolin Binding and Cellular Presentation of Lysophosphatidic Acid

2000 • 128 citations

Cell Type-specific Localization of Human Cardiac S1P Receptors

2002 • 120 citations

Rapid Activation of Neutral Sphingomyelinase by Hypoxia-Reoxygenation of Cardiac Myocytes

2000 • 116 citations

The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling

2003 • 94 citations

Early treatment of stroke with monosialoganglioside GM-1. Efficacy and safety results of the Early Stroke Trial.

1994 • 87 citations

Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner

2000 • 84 citations

Dual Regulation of EDG1/S1P1 Receptor Phosphorylation and Internalization by Protein Kinase C and G-protein-coupled Receptor Kinase 2

2002 • 81 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

N‐Glycans of sphingosine 1‐phosphate receptor Edg‐1 regulate ligand‐induced receptor internalization

2002 • 71 citations

Ganglioside GM1 in acute ischemic stroke. The SASS Trial.

1994 • 52 citations

Expression and characterization of Edg‐1 receptors in rat cardiomyocytes

2000 • 46 citations

Ganglioside GM1 Protection from Apoptosis of Rat Heart Fibroblasts

1999 • 45 citations

Protein Kinase C ϵ Dependence of the Recovery from Down-regulation of S1P1 G Protein-coupled Receptors of T Lymphocytes

2003 • 33 citations

Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

2000 • 30 citations