The Sphingosine Kinase-Sphingosine-1-Phosphate Axis Is a Determinant of Mast Cell Function and Anaphylaxis

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

2005 • 1,216 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Structural and functional characteristics of S1P receptors

2004 • 450 citations

Molecular regulation of mast cell activation

2006 • 449 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1993 • 369 citations

Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms

2006 • 365 citations

Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase

1997 • 337 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

Anaphylaxis: can we tell who is at risk of a fatal reaction?

2004 • 321 citations

Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

2001 • 318 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1

2003 • 216 citations

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient

2006 • 201 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Sphingosine 1‐phosphate/sphingosine 1‐phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression

2006 • 162 citations

The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

1999 • 154 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses

2005 • 140 citations

Dependence of mast cell IgE-mediated cytokine production on nuclear factor-κB activity

2000 • 132 citations

Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell

2005 • 130 citations

The Bcl10–Malt1 complex segregates FcεRI-mediated nuclear factor κB activation and cytokine production from mast cell degranulation

2006 • 126 citations

S1P₃receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF

2005 • 126 citations

Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cβ

2000 • 125 citations

Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine

1998 • 113 citations

Sphingosine 1-Phosphate, a Diffusible Calcium Influx Factor Mediating Store-operated Calcium Entry

2003 • 110 citations

Impaired FcεRI-Dependent Gene Expression and Defective Eicosanoid and Cytokine Production as a Consequence of Fyn Deficiency in Mast Cells

2005 • 104 citations

Regulation of protein kinase C by sphingosine and lysosphingolipids

1989 • 101 citations

Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation

2001 • 94 citations

The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation

2003 • 85 citations

Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness

2006 • 74 citations

Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases

2005 • 73 citations

Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

2004 • 69 citations

Sphingosine Inhibits Voltage-operated Calcium Channels in GH4C1 Cells

1998 • 50 citations

Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response

2005 • 43 citations

Enzymatic Method for Measurement of Sphingosine 1-Phosphate

2000 • 36 citations

Antigen-induced Ca2+ mobilization in RBL-2H3 cells: Role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production

2005 • 30 citations

Cellular Regulation of Sodium‐Calcium Exchange

2002 • 21 citations

Snake bites and bee stings: the mast cell strikes back

2006 • 21 citations

Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation

2006 • 18 citations

Mast Cell-Specific Genes – New Drug Targets/Pathogenesis

2005 • 7 citations

Inositol Lipids and Phosphates in the Proliferation and Differentiation of Lymphocytes and Myeloid Cells

2007 • 4 citations

Inositol lipids and phosphates in the proliferation and differentiation of lymphocytes and myeloid cells

1992 • 3 citations