Multiple Actions of Dimethylsphingosine in 1321N1 Astrocytes

Glutamate uptake

2001 • 3,867 citations

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

1994 • 2,646 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1995 • 1,124 citations

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1997 • 909 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy

2003 • 596 citations

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

2001 • 414 citations

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.

1994 • 267 citations

Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1994 • 240 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors

1997 • 193 citations

Janus Kinase 2, an Early Target of α7 Nicotinic Acetylcholine Receptor-mediated Neuroprotection against Aβ-(1–42) Amyloid

2002 • 174 citations

Alteration in temporal kinetics of Ca²⁺ signaling and control of growth and proliferation

2004 • 167 citations

Simultaneous Quantitative Determination Method for Sphingolipid Metabolites by Liquid Chromatography/Ionspray Ionization Tandem Mass Spectrometry

1997 • 147 citations

A Novel Sphingosine-dependent Protein Kinase (SDK1) Specifically Phosphorylates Certain Isoforms of 14-3-3 Protein

1998 • 130 citations

Calreticulin, Ca2+, and Calcineurin - Signaling from the Endoplasmic Reticulum

2004 • 120 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine

1998 • 113 citations

Expression cloning of a rat glutamate transporter

1993 • 104 citations

Quick and accurate method to convert BCECF fluorescence to pH_i: Calibration in three different types of cell preparations

1992 • 94 citations

Free sphingoid bases in normal murine tissues

1988 • 80 citations

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

1992 • 80 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

Nicotinic receptor subtypes in human brain related to aging and dementia

2001 • 62 citations

The effect of intracellular pH on cytosolic Ca 2+ in HT 29 cells

1996 • 46 citations

Calcium‐pH crosstalks in rat mast cells: cytosolic alkalinization, but not intracellular calcium release, is a sufficient signal for degranulation

2000 • 42 citations

The Action Mode of Lysophosphatidylcholine in Human Monocytes

2004 • 41 citations

Selectivity of Sphingosine-Induced Apoptosis

1998 • 40 citations

Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.

1998 • 32 citations

Intracellular pH and calcium signalling in rat pancreatic acinar cells

1997 • 18 citations

Dimethylsphingosine Regulates Intracellular pH and Ca2+ in Human Monocytes

2006 • 17 citations

Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells

2000 • 17 citations

Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes

2003 • 15 citations

Substrate-specific modulation of Src-mediated phosphorylation of Ras and caseins by sphingosines and other substrate modulators

1992 • 13 citations

Effect of dimethylsphingosine on muscarinic M3 receptor signalling in SH-SY5Y cells

2000 • 13 citations

Inhibition of Store-Operated Calcium Entry in Human Lymphocytes by Radiation: Protection by Glutathione

1999 • 10 citations

Endoplasmic Reticulum Ca2+ Store: Regulation of Ca2+ Release and Reuptake by Intracellular and Extracellular Ca2+ in Pancreatic Acinar Cells

2005 • 8 citations