Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine

Ca²⁺Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

2003 • 1,913 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 578 citations

Estrogen Modulation of Endothelial Nitric Oxide Synthase

2002 • 512 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

2005 • 429 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE

2005 • 420 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE₂production in response to TNF‐α

2003 • 318 citations

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

2002 • 309 citations

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension

2001 • 281 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

2001 • 268 citations

Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

2004 • 246 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase

2001 • 241 citations

Emerging medicinal roles for lysophospholipid signaling

2006 • 240 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Prostaglandin H Synthase and Vascular Function

2001 • 226 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

Sphingosine kinase 1 is up‐regulated in colon carcinogenesis

2005 • 218 citations

Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production

2001 • 201 citations

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease

2005 • 191 citations

Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine 1-Phosphate

2005 • 189 citations

Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)

2002 • 188 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate

2003 • 176 citations

Sphingosine‐1‐phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades

2001 • 171 citations

Endothelial Nitric Oxide Synthase Activation by Tumor Necrosis Factor α Through Neutral Sphingomyelinase 2, Sphingosine Kinase 1, and Sphingosine 1 Phosphate Receptors

2005 • 159 citations

Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae

2000 • 159 citations

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

2003 • 155 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner

2003 • 149 citations

Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase

2003 • 142 citations

Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid

2001 • 142 citations

The Coordination of Prostaglandin E₂ Production by Sphingosine-1-phosphate and Ceramide-1-phosphate

2005 • 142 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 142 citations

Cardiovascular effects of sphingosine‐1‐phosphate and other sphingomyelin metabolites

2004 • 137 citations

Sphingosylphosphorylcholine—biological functions and mechanisms of action

2002 • 132 citations

Sphingosylphosphorylcholine Is a Novel Messenger for Rho-Kinase–Mediated Ca ²⁺ Sensitization in the Bovine Cerebral Artery

2002 • 130 citations

Nitric Oxide-Induced Decrease in Calcium Sensitivity of Resistance Arteries Is Attributable to Activation of the Myosin Light Chain Phosphatase and Antagonized by the RhoA/Rho Kinase Pathway

2003 • 129 citations

Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles

2002 • 128 citations

The role of sphingosine-1-phosphate in smooth muscle contraction

2004 • 127 citations

Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P ₃

2005 • 122 citations

Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis

2002 • 121 citations

Lysophosphatidic acid alters cerebrovascular reactivity in piglets

1995 • 120 citations

S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

2003 • 119 citations

Sphingosine 1-phosphate and control of vascular tone

2003 • 119 citations

Antiproliferative Properties of Sphingosine 1-Phosphate in Human Hepatic Myofibroblasts

2000 • 117 citations

Thrombogenic and atherogenic activities of lysophosphatidic acid

2004 • 114 citations

High-Density Lipoprotein Stimulates Myocardial Perfusion In Vivo

2004 • 103 citations

Sphingosine‐1‐phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro

2000 • 103 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 102 citations

Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo

2001 • 100 citations

Photolysis of intracellular caged sphingosine‐1‐phosphate causes Ca²⁺ mobilization independently of G‐protein‐coupled receptors

2003 • 97 citations

Atheroprotective Effects of High-Density Lipoprotein-Associated Lysosphingolipids

2005 • 96 citations

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

2001 • 95 citations

Involvement of Src Family Protein Tyrosine Kinases in Ca ²⁺ Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway

2002 • 94 citations

Blood Lipid Mediator Sphingosine 1-Phosphate Potently Stimulates Platelet-derived Growth Factor-A and -B Chain Expression through S1P1-Gi-Ras-MAPK-dependent Induction of Krüppel-like Factor 5

2004 • 93 citations

Sphingosine 1-Phosphate–Related Metabolism in the Blood Vessel

2005 • 85 citations

Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner

2000 • 84 citations

Lysophospholipid receptor‐dependent and ‐independent calcium signaling

2004 • 82 citations

LPC in oxidized LDL elicits vasocontraction and inhibits endothelium- dependent relaxation

1994 • 82 citations

GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine

2005 • 77 citations

Regulation of vascular reactivity by established and emerging GPCRs

2005 • 76 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

Lysophosphatidic Acid-induced Ca2+ Mobilization Requires Intracellular Sphingosine 1-Phosphate Production

2000 • 71 citations

Evidence That Estrogen Suppresses Rho-Kinase Function in the Cerebral Circulation In Vivo

2004 • 69 citations

Sphingosine 1-Phosphate in Amniotic Fluid Modulates Cyclooxygenase-2 Expression in Human Amnion-derived WISH Cells

2003 • 67 citations

Sphingosylphosphorylcholine induces Ca²⁺‐sensitization of vascular smooth muscle contraction: possible involvement of Rho‐kinase

2000 • 64 citations

Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca²⁺-dependent pathway

1998 • 59 citations

Dihydrosphingosine 1‐phosphate stimulates MMP1 gene expression via activation of ERK1/2‐Ets1 pathway in human fibroblasts

2005 • 56 citations

Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I₂Pathway in Human Coronary Artery Smooth Muscle Cells

2004 • 56 citations

The Vasculopathy of Aging

1994 • 56 citations

Platelet-activating factor increases endothelial [Ca²⁺]_iand NO production in individually perfused intact microvessels

2005 • 51 citations

Sphingosine 1‐phosphate‐induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats

2004 • 49 citations

HDL action on the vascular wall: is the answer NO?

2004 • 47 citations

Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response

2005 • 43 citations

Sphingosylphosphorylcholine induces cytosolic Ca²⁺ elevation in endothelial cells in situ and causes endothelium‐dependent relaxation through nitric oxide production in bovine coronary artery

1999 • 43 citations

Sphingosine-1-Phosphate Receptor Expression and Signaling Correlate with Uterine Prostaglandin-Endoperoxide Synthase 2 Expression and Angiogenesis During Early Pregnancy1

2005 • 43 citations

Lipids: potential regulators of nitric oxide generation

2004 • 39 citations

Sphingosine-1-Phosphate Acts via Rho-Associated Kinase and Nitric Oxide to Regulate Human Placental Vascular Tone1

2005 • 39 citations

Sphingolipids differentially regulate mitogen‐activated protein kinases and intracellular Ca²⁺ in vascular smooth muscle: effects on CREB activation

2006 • 38 citations

Expression of Concern: Essential requirement for sphingosine kinase activity in eNOS‐dependent NO release and vasorelaxation

2005 • 38 citations

Lysosphingolipid receptor‐mediated diuresis and natriuresis in anaesthetized rats

2001 • 36 citations

Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: Activation of non-store-operated Ca entry

2005 • 33 citations

Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulmonary Arterial Rings

2005 • 31 citations

Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels

2003 • 30 citations

Sphingosine-1-phosphate activates BK_Cachannels independently of G protein-coupled receptor in human endothelial cells

2005 • 29 citations

Effects of neutral sphingomyelinase on phenylephrine-induced vasoconstriction and Ca2+ mobilization in rat aortic smooth muscle

2000 • 29 citations

Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation

2004 • 29 citations

Inhibition of Ca2+ signalling by the sphingosine 1-phosphate receptor S1P1

2003 • 26 citations

Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells

1998 • 25 citations

Sphingosine 1‐phosphate effect on endothelial cell PAF synthesis: Role in cellular migration

2003 • 24 citations

Nifedipine inhibits sphingosine-1-phosphate-induced renovascular contraction in vitro and in vivo

2001 • 24 citations

Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine

2003 • 22 citations

Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?

2002 • 22 citations

Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells

1998 • 18 citations

Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine

2006 • 18 citations

Distinct Ca²⁺ signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells

2000 • 16 citations

Comparison of noradrenaline and lysosphingolipid‐induced vasoconstriction in mouse and rat small mesenteric arteries

2004 • 16 citations

Sphingosine-1-Phosphate–Induced Intracellular Ca²⁺Mobilization in Human Endothelial Cells

2005 • 13 citations

C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration

2005 • 12 citations

Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Gαi3 protein and MAPK

2002 • 11 citations

Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death

2004 • 10 citations

Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat

2006 • 9 citations

Sphingosylphosphorylcholine induces Ca[2+]-sensitization of vascular smooth muscle contraction : possible involvement of Rho-kinaze

2001 • 5 citations

Abstracts (pages 57-63)

2003 • 1 citations

Deleted Work

1955 • 0 citations