Finding a way out: lymphocyte egress from lymphoid organs

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Homing and cellular traffic in lymph nodes

2003 • 1,233 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

2006 • 1,092 citations

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

2006 • 1,043 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

2007 • 861 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors

2004 • 532 citations

Kruppel-like factor 2 regulates thymocyte and T-cell migration

2006 • 527 citations

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology

2007 • 524 citations

Follicular shuttling of marginal zone B cells facilitates antigen transport

2007 • 513 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

2006 • 443 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

2004 • 436 citations

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

2006 • 406 citations

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

2004 • 403 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

2007 • 398 citations

Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor

2007 • 394 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

2005 • 318 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

1995 • 306 citations

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

2005 • 278 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

2006 • 253 citations

Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

2004 • 251 citations

Antigen-induced selective recruitment of circulating lymphocytes

1971 • 239 citations

Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells

2002 • 229 citations

Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus

2002 • 218 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

The Sphingosine Kinase-Sphingosine-1-Phosphate Axis Is a Determinant of Mast Cell Function and Anaphylaxis

2007 • 200 citations

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism

2006 • 198 citations

Sphingosine-1-Phosphate Mediates Migration of Mature Dendritic Cells

2005 • 191 citations

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

2007 • 182 citations

Krüppel-Like Factor 2 Controls T Cell Trafficking by Activating L-Selectin (CD62L) and Sphingosine-1-Phosphate Receptor 1 Transcription

2007 • 181 citations

FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells

2007 • 158 citations

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

2005 • 157 citations

Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

2006 • 156 citations

Tipping the gatekeeper: S1P regulation of endothelial barrier function

2007 • 150 citations

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress

2007 • 150 citations

A pertussis toxin‐sensitive process controls thymocyte emigration

1991 • 147 citations

A potential role for CD69 in thymocyte emigration

2002 • 144 citations

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity

2005 • 137 citations

The immediate effect of antigens on the cell output of a lymph node.

1965 • 133 citations

Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3

2007 • 131 citations

CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression.

1991 • 130 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1

2007 • 122 citations

The immunomodulator FTY720 interferes with effector functions of human monocyte‐derived dendritic cells

2005 • 121 citations

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells

2003 • 119 citations

The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell–expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches

2005 • 110 citations

The Generation of Mature, Single-Positive Thymocytes In Vivo Is Dysregulated by CD69 Blockade or Overexpression

2002 • 104 citations

Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production

2007 • 97 citations

マスト細胞からのスフィンゴシン‐1‐りん酸の運び出しに果たすABCC1の役割

2006 • 95 citations

Essential Requirement for Sphingosine Kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues

2007 • 87 citations

Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720

2005 • 85 citations

Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics

2007 • 83 citations

Thymic microvascular system

1997 • 83 citations

FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs

2006 • 74 citations

Systematic identification of regulatory proteins critical for T-cell activation.

2003 • 69 citations

Immunological Effects of Transgenic Constitutive Expression of the Type 1 Sphingosine 1-Phosphate Receptor by Mouse Lymphocytes

2005 • 64 citations

Cutting Edge: Regulation of T Cell Trafficking and Primary Immune Responses by Sphingosine 1-Phosphate Receptor 1

2005 • 62 citations

Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement

2005 • 59 citations

The kinetics of antigen-reactive cells during lymphocyte recruitment

1974 • 50 citations

FTY720 suppresses humoral immunity by inhibiting germinal center reaction

2004 • 45 citations

Defective Chemokine-Directed Lymphocyte Migration and Development in the Absence of Rho Guanosine Diphosphate-Dissociation Inhibitors α and β

2006 • 44 citations

Th17 Augmentation in OTII TCR Plus T Cell-Selective Type 1 Sphingosine 1-Phosphate Receptor Double Transgenic Mice

2007 • 43 citations

The lymphocyte — a disgraceful gap in medical knowledge

1996 • 37 citations

Enhanced FTY720-Mediated Lymphocyte Homing Requires Gαi Signaling and Depends on β2 and β7 Integrin

2006 • 18 citations