The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP₃

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

1998 • 939 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 • 908 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

2002 • 580 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

1999 • 442 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Glycogen Synthase Kinase-3: Properties, Functions, and Regulation

2001 • 390 citations

Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

2002 • 389 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

2002 • 360 citations

The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

1999 • 358 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

2000 • 287 citations

Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 • 284 citations

New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

2000 • 269 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 245 citations

Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition

1999 • 244 citations

p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes

1997 • 243 citations

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

1999 • 241 citations

The role of cell cycle‐mediated events in Alzheimer's disease

1999 • 220 citations

The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes

2000 • 214 citations

Vav proteins, adaptors and cell signaling

2001 • 212 citations

Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

2000 • 211 citations

Constitutively Activated Akt-1 Is Vital for the Survival of Human Monocyte-Differentiated Macrophages

2001 • 209 citations

Phosphoinositide 3-kinase in immunological systems

2002 • 206 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 197 citations

Regulation of translation initiation factors by signal transduction

1998 • 195 citations

CD28 Costimulation Mediates Down-Regulation of p27kip1and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells

2002 • 191 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

T cell receptor signalling

2001 • 188 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway

2002 • 164 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

2000 • 162 citations

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

1995 • 161 citations

Glycogen Synthase Kinase-3 Inhibits the DNA Binding Activity of NFATc

2001 • 161 citations

CD28: a signalling perspective

1996 • 156 citations

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21^ras

1995 • 155 citations

Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-κB-Dependent Transcription

2002 • 151 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Inhibition of T and B lymphocyte proliferation by rapamycin.

1991 • 144 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

2002 • 140 citations

p70^s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

1999 • 138 citations

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

2002 • 136 citations

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

2001 • 129 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide–protein co‐operative mechanism

2001 • 127 citations

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

2000 • 127 citations

Protein kinase B (Akt) regulation and function in T lymphocytes

2002 • 125 citations

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1995 • 124 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

1994 • 124 citations

Dopamine depletion and subsequent treatment with <scp>l</scp>‐DOPA, but not the long‐lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum

2007 • 121 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

The protein interactions of the immunoglobulin receptor family tyrosine‐based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

1996 • 114 citations

Phosphoinositide 3-kinases in T lymphocyte activation

2001 • 111 citations

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1998 • 111 citations

Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport

1999 • 103 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

1997 • 102 citations

Brain‐derived neurotrophic factor regulates the expression of D₁ dopamine receptors

2006 • 99 citations

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo

1999 • 99 citations

CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation

2000 • 95 citations

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3

1996 • 95 citations

Thymocyte Development in Early Growth Response Gene 1-Deficient Mice

2002 • 95 citations

Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans

1996 • 93 citations

Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription

2000 • 92 citations

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

2002 • 91 citations

T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38

1995 • 90 citations

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2

2002 • 87 citations

The effect of the immunosuppressant FK‐506 on alternate pathways of T cell activation

1991 • 82 citations

p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

1995 • 80 citations

Cutting Edge: Gab2 Mediates an Inhibitory Phosphatidylinositol 3′-Kinase Pathway in T Cell Antigen Receptor Signaling

2000 • 68 citations

CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation

1995 • 61 citations

Targets of B‐cell antigen receptor signaling: the phosphatidylinositol 3‐kinase/Akt/glycogen synthase kinase‐3 signaling pathway and the Rap1 GTPase

2000 • 59 citations

The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis

2000 • 59 citations

Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein- associated p62 protein

1998 • 59 citations

A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

1997 • 59 citations

Tyrosine Phosphorylation of the CD3-ε Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells

1997 • 54 citations

AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain

2001 • 52 citations

T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck.

1994 • 45 citations

Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.

1998 • 43 citations

The T cell antigen receptor activates phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1

2000 • 41 citations

Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A.

1991 • 34 citations

Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression

2002 • 34 citations

Cutting Edge: Nuclear Factor of Activated T Cells and AP-1 Are Insufficient for IL-2 Promoter Activation: Requirement for CD28 Up-Regulation of RE/AP

1998 • 31 citations

Signal transduction pathways that contribute to increased protein synthesis during T-cell activation

2000 • 31 citations

A phosphoinositide-binding sequence is shared by PH domain target molecules—a model for the binding of PH domains to proteins

1998 • 28 citations

Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells.

1996 • 26 citations

Aggregation of the human high affinity immunoglobulin G receptor (FcγRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms

1998 • 26 citations

SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY

2002 • 22 citations

The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.

2002 • 20 citations

Regulation of T Cell Development in the Thymus

2000 • 18 citations