SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

LAT

1998 • 1,251 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

THE HIGH-AFFINITY I<scp>g</scp>E RECEPTOR (FcεRI): From Physiology to Pathology

1999 • 949 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading

2001 • 404 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

From TCR Engagement to T Cell Activation

1999 • 379 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

α, β, γ, and δ T Cell Antigen Receptor Genes Arose Early in Vertebrate Phylogeny

1997 • 285 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

1999 • 245 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling

1998 • 226 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

Signal Transduction by the High-Affinity Immunoglobulin E Receptor FcεRI: Coupling Form to Function

2001 • 206 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

1998 • 181 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

p21ras mediates control of IL-2 gene promoter function in T cell activation.

1992 • 166 citations

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

1994 • 159 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

1998 • 156 citations

Adaptor proteins in lymphocyte antigen-receptor signaling

1998 • 155 citations

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

2000 • 155 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

Molecular Cloning of the cDNA Encoding pp36, a Tyrosine-phosphorylated Adaptor Protein Selectively Expressed by T Cells and Natural Killer Cells

1998 • 151 citations

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

1999 • 147 citations

Requirement for the SLP-76 Adaptor GADS in T Cell Development

2001 • 145 citations

Interaction between the Btk PH Domain and Phosphatidylinositol-3,4,5-trisphosphate Directly Regulates Btk

2001 • 133 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

1998 • 131 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

1996 • 129 citations

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.

1992 • 125 citations

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation

1999 • 121 citations

Functional dissection of BCR signaling pathways

2000 • 120 citations

Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56^lck Complex in Human T‐Cell Activation

1989 • 118 citations

Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling

2000 • 114 citations

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

1998 • 114 citations

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

1999 • 110 citations

Towards prediction of cognate complexes between the WW domain and proline‐rich ligands

1996 • 108 citations

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.

1994 • 103 citations

Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 in Human T-lymphocytes

1997 • 102 citations

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1999 • 100 citations

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

1999 • 98 citations

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase

1996 • 95 citations

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

1998 • 95 citations

SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction

1996 • 92 citations

T cell antigen receptor signaling: Three families of tyrosine kinases and a phosphatase

1994 • 92 citations

T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38

1995 • 90 citations

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane

2000 • 79 citations

Novel Isoform of Lymphoid Adaptor FYN-T-binding Protein (FYB-130) Interacts with SLP-76 and Up-regulates Interleukin 2 Production

1999 • 74 citations

Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.

1998 • 70 citations

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.

1994 • 68 citations

Optic flow: A brain region devoted to optic flow analysis?

1998 • 66 citations

The Adaptor Protein Gads (Grb2-Related Adaptor Downstream of Shc) Is Implicated in Coupling Hemopoietic Progenitor Kinase-1 to the Activated TCR

2000 • 62 citations

Regulation of TCR Signal Transduction in Murine Thymocytes by Multiple TCR ζ-Chain Signaling Motifs

1998 • 60 citations

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells

2000 • 58 citations

Reconstitution of T Cell Antigen Receptor‐Induced Erk2 Kinase Activation in Lck‐Negative JCaM1 Cells by Syk

1997 • 47 citations

Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells.

1997 • 45 citations

Characterization of protein kinase C and its isoforms in human T lymphocytes.

1988 • 38 citations

Adaptor proteins and T-cell antigen receptor signaling

1999 • 35 citations

Molecular Cloning and Expression of HumanGrap-2, a Novel Leukocyte-Specific SH2- and SH3-Containing Adaptor-like Protein That Binds toGab-1

1998 • 32 citations

Signal Transduction Elements of the B Cell Antigen Receptor and their Role in Immunodeficiencies

2000 • 15 citations