New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation

2001 • 548 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

2001 • 304 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

2002 • 274 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk

2000 • 206 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

Btk function in B cell development and response

1998 • 181 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

1998 • 155 citations

Tec Kinases

2000 • 151 citations

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization

2001 • 143 citations

A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.

1990 • 139 citations

Interaction between the Btk PH Domain and Phosphatidylinositol-3,4,5-trisphosphate Directly Regulates Btk

2001 • 133 citations

Pleckstrin Homology Domains Interact with Filamentous Actin

1999 • 133 citations

Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

2001 • 132 citations

BLNK mediates Syk-dependent Btk activation

2001 • 132 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

Phospholipase C-γ2 Couples Bruton's Tyrosine Kinase to the NF-κB Signaling Pathway in B Lymphocytes

2001 • 129 citations

Association of SLP-65 / BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-α

2001 • 129 citations

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

2000 • 120 citations

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

2000 • 104 citations

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

2001 • 104 citations

The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-κB and Cell Cycle Entry and Survival of B Lymphocytes

2001 • 103 citations

Tec kinases: modulators of lymphocyte signaling and development

2001 • 100 citations

Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling

2001 • 91 citations

Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase

2000 • 91 citations

Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

1997 • 89 citations

Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein

2001 • 87 citations

rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

1999 • 86 citations

A specific intermolecular association between the regulatory domains of a tec family kinase

2000 • 85 citations

Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

2001 • 79 citations

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain

2001 • 78 citations

Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase

2002 • 73 citations

Emt/Itk Associates with Activated TCR Complexes: Role of the Pleckstrin Homology Domain

1999 • 66 citations

Transcription Factor STAT5A Is a Substrate of Bruton's Tyrosine Kinase in B Cells

2001 • 65 citations

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

2001 • 64 citations

A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells

2001 • 62 citations

Bruton's Tyrosine Kinase Regulates the Activation of Gene Rearrangements at the λ Light Chain Locus in Precursor B Cells in the Mouse

2001 • 57 citations

Txk, a Member of Nonreceptor Tyrosine Kinase of Tec Family, Acts as a Th1 Cell-Specific Transcription Factor and Regulates IFN-γ Gene Transcription

2002 • 55 citations

Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA)

2000 • 52 citations

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

2001 • 47 citations

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

2001 • 44 citations

The Solution Structure and Intramolecular Associations of the Tec Kinase Src Homology 3 Domain

2002 • 44 citations

Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 44 citations

Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy

2001 • 37 citations

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α)

2001 • 33 citations

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 33 citations

Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition

2001 • 32 citations

G Protein βγ Subunits Act on the Catalytic Domain to Stimulate Bruton's Agammaglobulinemia Tyrosine Kinase

2002 • 32 citations

xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development

2001 • 28 citations

Identification of Phosphorylation Sites for Bruton's Tyrosine Kinase within the Transcriptional Regulator BAP/TFII-I

2001 • 27 citations

Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

2001 • 27 citations

Bruton's tyrosine kinase associates with the actin‐based cytoskeleton in activated platelets

2001 • 26 citations

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk

2001 • 17 citations

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk

2001 • 17 citations

Hematopoietic cell‐specific adapter proteins, SLP‐76 and BLNK, effectively activate NF‐AT as well as NF‐κB by Syk and Tec PTKs in non‐lymphoid cell lines

2001 • 16 citations

Role of the PHTH Module in Protein Substrate Recognition by Bruton's Agammaglobulinemia Tyrosine Kinase

2001 • 16 citations

Both proline‐rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain

2001 • 15 citations

Bruton's tyrosine kinase is a substrate of calpain in human platelets

2001 • 11 citations