Regulation of T Cell Development in the Thymus

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.

1988 • 301 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

T-cell selection

1998 • 168 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Identification and Characterization of the Egr-1 Gene Product, a DNA-Binding Zinc Finger Protein Induced by Differentiation and Growth Signals

1990 • 108 citations

Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.

1994 • 90 citations

Raf regulates positive selection

1996 • 90 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

A Ternary Complex Factor-Dependent Mechanism Mediates Induction of egr-1 through Selective Serum Response Elements following Antigen Receptor Cross-Linking in B Lymphocytes

1995 • 72 citations

Differentiation of an immature T cell line: A model of thymic positive selection

1992 • 63 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.

1996 • 61 citations

In vitro differentiation and commitment of CD4⁺ thymocytes to the CD4⁺ lineage without TCR engagement

1996 • 59 citations

Live Cell Fluorescence Imaging of T Cell MEKK2

1999 • 50 citations

Modulation of Thymic Selection by Expression of an Immediate-early Gene, Early Growth Response 1 (Egr-1)

1998 • 50 citations

Small cortical thymocytes are subject to positive selection.

1994 • 38 citations

Slow Accumulation of Active Mitogen-Activated Protein Kinase During Thymocyte Differentiation Regulates the Temporal Pattern of Transcription Factor Gene Expression

1999 • 34 citations

Identification of Residues Critical for Ras(17N) Growth-Inhibitory Phenotype and for Ras Interaction with Guanine Nucleotide Exchange Factors

1994 • 23 citations

Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation

1994 • 18 citations