Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Co-stimulation in T cell responses

1997 • 430 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

T cell clonal anergy

1997 • 257 citations

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

1990 • 253 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells

1996 • 108 citations

Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.

1997 • 104 citations

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 • 103 citations

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2

1998 • 89 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

Molecular Regulation of the IL‐2 Gene: Rheostatic Control of the Immune System

1993 • 64 citations

Regulation of the Interleukin-2 Gene

2015 • 47 citations

Regulation of the Interleukin-2 Gene (Part 1 of 2)

1992 • 23 citations