Signal transduction pathways that contribute to increased protein synthesis during T-cell activation

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1993 • 6,546 citations

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1995 • 2,723 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

The PI3K–PDK1 connection: more than just a road to PKB

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Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E

1999 • 635 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

The PI3K‒PDK1 connection: more than just a road to PKB

2000 • 503 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

1999 • 449 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways

1998 • 302 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

FK506, An Immunosuppressant Targeting Calcineurin Function

2000 • 242 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis

1999 • 199 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

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Regulation of translation initiation factors by signal transduction

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Protein kinase C and T cell activation

1990 • 183 citations

Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.

1993 • 182 citations

p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells

1999 • 179 citations

Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthesis by Amino Acids in L6 Myoblasts

1998 • 166 citations

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt‐3

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Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G₁ phase of the cycle

1993 • 154 citations

Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts

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S6 Phosphorylation and the p70^s6k/p85^s6k

1994 • 148 citations

Inhibition of T and B lymphocyte proliferation by rapamycin.

1991 • 144 citations

Calcineurin Is a Key Signaling Enzyme in T Lymphocyte Activation and the Target of the Immunosuppressive Drugs Cyclosporin A and FK506^a

1993 • 131 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes.

1987 • 122 citations

Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.

1994 • 117 citations

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinase

1997 • 101 citations

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3

1996 • 95 citations

Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans

1996 • 93 citations

Translational controls impinging on the 5′-untranslated region and initiation factor proteins

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T lymphocyte activation: a biological model of signal transduction.

1990 • 76 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

Different Protein Kinase C Isoenzymes Regulate IL-2 Receptor Expression or IL-2 Synthesis in Human Lymphocytes Stimulated via the TCR

1998 • 68 citations

Regulation of translation initiation factor gene expression during human T cell activation.

1992 • 64 citations

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

1992 • 64 citations

Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells.

1993 • 61 citations

Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells

1997 • 59 citations

Regulation of gene expression for translation initiation factor eIF-2α: importance of the 3′ untranslated region

1996 • 57 citations

Cell Biology and Immunology of Leukocyte Function

1980 • 55 citations

Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes

1989 • 55 citations

Signalling through either the p38 or ERK mitogen‐activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR‐CD3)‐stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells

1997 • 52 citations

Comparison of phorbol ester/calcium ionophore and phytohemagglutinin-induced signaling in human T lymphocytes. Demonstration of interleukin 2-independent transferrin receptor gene expression.

1988 • 47 citations

Distinct Repression of Translation by Wortmannin and Rapamycin

1997 • 44 citations

Phorbol ester synergizes with Ca2+ ionophore in activation of protein kinase C (PKC)alpha and PKC beta isoenzymes in human T cells and in induction of related cellular functions.

1992 • 44 citations

Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor

1996 • 43 citations

Evidence for translational control of “early” protein synthesis in lymphocytes stimulated with concanavaline A

1974 • 42 citations

Regulation of eukaryotic translation initiation factor expression during T-cell activation

1993 • 40 citations

Lymphocyte activation the coming of the protein tyrosine phosphatases

1998 • 37 citations

Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the α and γ subunits of the initiation factor complex eIF-4F

1995 • 37 citations

Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores

1988 • 32 citations

Signal Transduction by the Antigen Receptors of B and T Lymphocytes

1995 • 28 citations

Mechanism of activation of protein synthesis initiation in mitogen-stimulated T lymphocytes

1991 • 24 citations

Distribution of Lymphocyte Messenger RNA during Stimulation by Phytohaemagglutinin

1979 • 22 citations

Signalling pathways which regulate eIF4E

1997 • 18 citations

REGULATION OF PROTEIN SYNTHESIS DURING LYMPHOCYTE ACTIVATION BY PHYTOHAEMAGGLUTININ

1979 • 8 citations