The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

1998 • 939 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5

1993 • 404 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

1997 • 336 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5

1993 • 318 citations

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

1998 • 308 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

1995 • 296 citations

A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.

1987 • 284 citations

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.

1994 • 249 citations

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

1993 • 208 citations

Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells

1994 • 196 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response

1998 • 191 citations

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

1996 • 171 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

1994 • 159 citations

A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP.

1988 • 145 citations

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor

1995 • 121 citations

Tyrosine phosphorylation of receptor beta subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor.

1992 • 90 citations

Interleukin-3-dependent expression of the c-myc and c-fos proto-oncogenes in hemopoietic cell lines.

1986 • 89 citations

JAK2 Associates with the β_c Chain of the Receptor for Granulocyte-Macrophage Colony-Stimulating Factor, and Its Activation Requires the Membrane-Proximal Region

1994 • 85 citations

Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133

1995 • 68 citations

Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor

1996 • 52 citations

Overexpression of activation transcriptional factor 1 in lymphomas and in activated lymphocytes.

1995 • 32 citations

Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth.

1995 • 21 citations

AP‐1‐Related Proteins Bind to the Enkephalin CRE‐2 Element in Adrenal Chromaffin Cells

1996 • 14 citations